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Q31B42

- UPPP_PROM9

UniProt

Q31B42 - UPPP_PROM9

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, PMT9312_0843
Organism
Prochlorococcus marinus (strain MIT 9312)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciPMAR74546:GHRG-863-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:PMT9312_0843
OrganismiProchlorococcus marinus (strain MIT 9312)
Taxonomic identifieri74546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002715: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei41 – 6121Helical; Reviewed prediction
Add
BLAST
Transmembranei89 – 10921Helical; Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Transmembranei155 – 17521Helical; Reviewed prediction
Add
BLAST
Transmembranei191 – 21121Helical; Reviewed prediction
Add
BLAST
Transmembranei218 – 23821Helical; Reviewed prediction
Add
BLAST
Transmembranei248 – 26821Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 268268Undecaprenyl-diphosphataseUniRule annotation
PRO_0000250249Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74546.PMT9312_0843.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiERIFITE.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q31B42-1 [UniParc]FASTAAdd to Basket

« Hide

MFSEYLKFFL YGLIQGLTEF FPVSSTAHLK VISVFFGIDD PGPSLSAIIQ    50
LGSVLALVCY FRNDFFKLKI QSSKKIFDYL IHERLLRSIF IGTIPIILLG 100
GTIKLFVPYF FDEIFRSNLS IALVSFLMAI LMYIADRSKK GSINLKNHKY 150
SDSFLIGLSQ ALAIFPGVSR SGVTISTALL SGWGRSDSAK FSFLLGMPAI 200
SFAAIVEFIS SFNAFSSFSF FPLIVGLTTT FLSSLLAIHF LLKYFSSNGL 250
KLFIIYRIVF GFVILLNL 268
Length:268
Mass (Da):29,926
Last modified:December 6, 2005 - v1
Checksum:iA00494660707E9F0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000111 Genomic DNA. Translation: ABB49903.1.
RefSeqiYP_397339.1. NC_007577.1.

Genome annotation databases

EnsemblBacteriaiABB49903; ABB49903; PMT9312_0843.
GeneIDi3765643.
KEGGipmi:PMT9312_0843.
PATRICi23005438. VBIProMar70153_0898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000111 Genomic DNA. Translation: ABB49903.1 .
RefSeqi YP_397339.1. NC_007577.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 74546.PMT9312_0843.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB49903 ; ABB49903 ; PMT9312_0843 .
GeneIDi 3765643.
KEGGi pmi:PMT9312_0843.
PATRICi 23005438. VBIProMar70153_0898.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi ERIFITE.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci PMAR74546:GHRG-863-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Prochlorococcus marinus str. MIT 9312."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9312.

Entry informationi

Entry nameiUPPP_PROM9
AccessioniPrimary (citable) accession number: Q31B42
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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