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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Prochlorococcus marinus (strain MIT 9312)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei625ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR74546:G1G51-940-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PMT9312_0911
OrganismiProchlorococcus marinus (strain MIT 9312)
Taxonomic identifieri74546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002715 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093941 – 856Leucine--tRNA ligaseAdd BLAST856

Proteomic databases

PRIDEiQ31AX4

Interactioni

Protein-protein interaction databases

STRINGi74546.PMT9312_0911

Structurei

3D structure databases

ProteinModelPortaliQ31AX4
SMRiQ31AX4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi53 – 63"HIGH" regionAdd BLAST11
Motifi622 – 626"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200747
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q31AX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISPDKQYET DTNLYNPSEI EKKWQSIWTE NNLYKTDELT ENSDKFYALS
60 70 80 90 100
MFPYPSGNLH MGHVRNYVIT DLIARFQRFK GKSVLHPMGW DAFGLPAENA
110 120 130 140 150
AIERGISPSV WTKKNISHMK SQLKLLGLSV DWDREFATCD ENYYIWTQYL
160 170 180 190 200
FLELYKAGLV YQKESEVNWD PIDNTVLANE QVDSEGKSWR SGALVEKKLL
210 220 230 240 250
KQWFLRITNY ADELLKDLEK LDNWPERVKI MQDNWIGKSI GTNINFNINT
260 270 280 290 300
NPEKKITVFT TRPDTLFGVT YLAISINHSL IKNISDQETI QDIENLKQYL
310 320 330 340 350
KNNKNNELEK IGIKTSLIAI NPVNSEPIPI WVASYVLDEY GTGAVMGVPA
360 370 380 390 400
HDLRDFEFAK KNNIDIKHVI IKDKSEKTKE LDEAYVENGY LINSNHFNGI
410 420 430 440 450
ANTIAKLKIS EEGVNNGWAE NKIQYRLRDW LISRQRYWGC PIPIVNCKKC
460 470 480 490 500
GSVPLNQSEL PVALPKDIDI SANKINALGD NYNWINTTCP KCGIAAKKET
510 520 530 540 550
DTMDTFMCSS WYFLRYPSSR CSTKPFEKIE INNWLPVDQY VGGVEHAILH
560 570 580 590 600
LLYARFFTKA LRDNELFEID EPFKKLLTQG MVQSAAYKNN KTGKYISPSD
610 620 630 640 650
INDLSNPTDP IDNSKLEVLF EKMSKSKYNG IDPESVIKKY GADTARMFIL
660 670 680 690 700
FKAPPEKDLE WGDSDVEGQF RFLSRIWKLY ISCSKDINSK SKSYPNKEKT
710 720 730 740 750
LIKSMNIAIK EITNDISNNQ FNTAISELMK FYNSLSNNIN DVNNNLKIDA
760 770 780 790 800
LKTFCILLAP FAPHISEEIW LLIGFKNSVH LEHWPSFNAE ALKEDSYVLV
810 820 830 840 850
IQVNGKVRDK ININNEMNED QIKELTLKRP NILKWTQDKE IRKIIIVKGK

IMNIVV
Length:856
Mass (Da):98,666
Last modified:December 6, 2005 - v1
Checksum:i0ADE75F2D85B2663
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000111 Genomic DNA Translation: ABB49971.1
RefSeqiWP_011376465.1, NC_007577.1

Genome annotation databases

EnsemblBacteriaiABB49971; ABB49971; PMT9312_0911
KEGGipmi:PMT9312_0911

Similar proteinsi

Entry informationi

Entry nameiSYL_PROM9
AccessioniPrimary (citable) accession number: Q31AX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health