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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Prochlorococcus marinus (strain MIT 9312)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciPMAR74546:G1G51-991-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:PMT9312_0959
OrganismiProchlorococcus marinus (strain MIT 9312)
Taxonomic identifieri74546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002715 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000201251 – 328Methionyl-tRNA formyltransferaseAdd BLAST328

Interactioni

Protein-protein interaction databases

STRINGi74546.PMT9312_0959

Structurei

3D structure databases

ProteinModelPortaliQ31AS6
SMRiQ31AS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
OrthoDBiPOG091H01YM

Family and domain databases

HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q31AS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIIFWGTPE YSISSLDIFI KSKHEVIAVV SQPDKKRSRG KKLISSPVKS
60 70 80 90 100
FAEQESIKIY TPEKIRDNIN FINELKSLSC DLFIVIAYGK ILPKEILEIP
110 120 130 140 150
KFGCWNAHAS LLPRWRGAAP IQWSLMKGDE FTGVGIMKMN EGLDTGDLLL
160 170 180 190 200
EEKIKIDNND NLITLTEKLS ILSAKLFLNA TSLLEENINK NTNYQLTKQN
210 220 230 240 250
TLGREITYAR MIEKSDYKVD WGNEAIKISR KIKALYPRAN TTFRGKNLKI
260 270 280 290 300
IKIKVLSSDE INNEKYCLMS NYSKPGIILA VLENEGIIIS TKTDPIILLE
310 320
AKLEGKNISS KKQLIQQLKP SLGEYLSN
Length:328
Mass (Da):37,226
Last modified:December 6, 2005 - v1
Checksum:i596F4EE7175905D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000111 Genomic DNA Translation: ABB50019.1
RefSeqiWP_011376511.1, NC_007577.1

Genome annotation databases

EnsemblBacteriaiABB50019; ABB50019; PMT9312_0959
KEGGipmi:PMT9312_0959

Similar proteinsi

Entry informationi

Entry nameiFMT_PROM9
AccessioniPrimary (citable) accession number: Q31AS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: April 25, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health