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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Prochlorococcus marinus (strain MIT 9312)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15FADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciPMAR74546:G1G51-1169-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:PMT9312_1127
OrganismiProchlorococcus marinus (strain MIT 9312)
Taxonomic identifieri74546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002715 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003463791 – 470Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST470

Interactioni

Protein-protein interaction databases

STRINGi74546.PMT9312_1127

Structurei

3D structure databases

ProteinModelPortaliQ31AA9
SMRiQ31AA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI Bacteria
COG1206 LUCA
HOGENOMiHOG000252054
KOiK04094
OMAiRFGPMKP
OrthoDBiPOG091H00B3

Family and domain databases

Gene3Di3.50.50.60, 2 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR020595 MnmG-rel_CS
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 2 hits
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit
PROSITEiView protein in PROSITE
PS01281 GIDA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q31AA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDKEVIVIG AGLAGSEAAW QIANAGVPVK LVEMRPYKST PAHHTGEFGE
60 70 80 90 100
LVCSNSFGAI SADRAAGLLQ KELRIFNSLI VQTADKFAVP AGGALAVDRS
110 120 130 140 150
KFSNALTETL SNHPLINIKR IEQLDLPSKE NITILATGPL TSDDLAYKIQ
160 170 180 190 200
DFTGIDDCHF FDAASPIIYG DSIDHEIVFK ASRYDKGDPA YLNCPMDKYE
210 220 230 240 250
YTNFRNQLIE GEQANLKDFE KESANFFEAC LPIEEIARRG IDTMRYGPLK
260 270 280 290 300
SIGLWNPKWG DLFDRDNRLK KRPHAIVQLR KEDLEGKLLN MVGFQTNLKW
310 320 330 340 350
SEQKRIFRII PGLEKAEFVR FGVMHRNTFL ESPKLLLPTL QFMKRESLFA
360 370 380 390 400
AGQITGTEGY AAAAAGGLLA GINASLIAKG EIAVTFPDES MIGSLMNFIS
410 420 430 440 450
NRNKIMSSQK KNKFQPIPAS FGLVPELTKR IKDKRSRYIA YQQRSVDVLN
460 470
IFKRKLDYIF NKDHTLVKIN
Length:470
Mass (Da):52,630
Last modified:December 6, 2005 - v1
Checksum:i3EA80D8F93277B1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000111 Genomic DNA Translation: ABB50186.1
RefSeqiWP_011376677.1, NC_007577.1

Genome annotation databases

EnsemblBacteriaiABB50186; ABB50186; PMT9312_1127
KEGGipmi:PMT9312_1127

Similar proteinsi

Entry informationi

Entry nameiTRMFO_PROM9
AccessioniPrimary (citable) accession number: Q31AA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health