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Q319M2

- NADK2_PROM9

UniProt

Q319M2 - NADK2_PROM9

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Protein

NAD kinase 2

Gene
nadK2, PMT9312_1363
Organism
Prochlorococcus marinus (strain MIT 9312)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei79 – 791Proton acceptor By similarity
Binding sitei183 – 1831NAD By similarity
Binding sitei218 – 2181NAD; via carbonyl oxygen By similarity
Binding sitei252 – 2521NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi79 – 802NAD By similarity
Nucleotide bindingi153 – 1542NAD By similarity
Nucleotide bindingi194 – 1996NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR74546:GHRG-1395-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2 (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase 2
Gene namesi
Name:nadK2
Ordered Locus Names:PMT9312_1363
OrganismiProchlorococcus marinus (strain MIT 9312)
Taxonomic identifieri74546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002715: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302NAD kinase 2UniRule annotationPRO_0000229669Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74546.PMT9312_1363.

Structurei

3D structure databases

ProteinModelPortaliQ319M2.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227222.
KOiK00858.
OMAiTHEMLYH.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q319M2-1 [UniParc]FASTAAdd to Basket

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MVLKAGLIVN DGKELAVQTA SSVQEKLEKS NYEVIRVSSS GGMVGFANPD    50
QHVRPLGYTN CVPEGFDSSM EFAIVLGGDG TVLSAARQTA PAKIPILTIN 100
TGHLGFLAEA YLSNLNEAID KIITGNWDIE ERTCFIVSVM RNDQRRWESL 150
CLNEMALHRE PLTSMCHFEI SIGRHAPVDI SADGVILSTP TGSTAYSLSA 200
GGPVITPDCP VVQLTPIAPH SLASRALVFN DSEPVTVFPA TPERLVMVVD 250
GNAGCYVWPE DRVLIRKSKH SVKFIRLEDH EFFQVLRNKL GWGLPHVAKP 300
NK 302
Length:302
Mass (Da):32,932
Last modified:December 6, 2005 - v1
Checksum:iFD6D532F6441468A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000111 Genomic DNA. Translation: ABB50423.1.
RefSeqiYP_397859.1. NC_007577.1.

Genome annotation databases

EnsemblBacteriaiABB50423; ABB50423; PMT9312_1363.
GeneIDi3766175.
KEGGipmi:PMT9312_1363.
PATRICi23006658. VBIProMar70153_1496.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000111 Genomic DNA. Translation: ABB50423.1 .
RefSeqi YP_397859.1. NC_007577.1.

3D structure databases

ProteinModelPortali Q319M2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 74546.PMT9312_1363.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB50423 ; ABB50423 ; PMT9312_1363 .
GeneIDi 3766175.
KEGGi pmi:PMT9312_1363.
PATRICi 23006658. VBIProMar70153_1496.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227222.
KOi K00858.
OMAi THEMLYH.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci PMAR74546:GHRG-1395-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Prochlorococcus marinus str. MIT 9312."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9312.

Entry informationi

Entry nameiNADK2_PROM9
AccessioniPrimary (citable) accession number: Q319M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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