Reviewed, UniProtKB/Swiss-Prot Q319M2 (PPNK2_PROM9)

Names and origin

Protein names

Recommended name:
    Probable inorganic polyphosphate/ATP-NAD kinase 2
      Short name=Poly(P)/ATP NAD kinase 2
    EC=2.7.1.23

Gene names

Name:	ppnK2
Ordered Locus Names:	PMT9312_1363

Organism

Prochlorococcus marinus (strain MIT 9312) [Complete proteome] [HAMAP]

Taxonomic identifier

74546 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Probable inorganic polyphosphate/ATP-NAD kinase 2 HAMAP MF_00361		PRO_0000229669

Sequences

	Sequence		Length	Mass (Da)
	Q319M2-1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: FD6D532F6441468A	FASTA	302	32,932
	10 20 30 40 50 60 MVLKAGLIVN DGKELAVQTA SSVQEKLEKS NYEVIRVSSS GGMVGFANPD QHVRPLGYTN 70 80 90 100 110 120 CVPEGFDSSM EFAIVLGGDG TVLSAARQTA PAKIPILTIN TGHLGFLAEA YLSNLNEAID 130 140 150 160 170 180 KIITGNWDIE ERTCFIVSVM RNDQRRWESL CLNEMALHRE PLTSMCHFEI SIGRHAPVDI 190 200 210 220 230 240 SADGVILSTP TGSTAYSLSA GGPVITPDCP VVQLTPIAPH SLASRALVFN DSEPVTVFPA 250 260 270 280 290 300 TPERLVMVVD GNAGCYVWPE DRVLIRKSKH SVKFIRLEDH EFFQVLRNKL GWGLPHVAKP NK

References

[1]

"Complete sequence of Prochlorococcus marinus str. MIT 9312." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000111 Genomic DNA. Translation: ABB50423.1.
RefSeq	YP_397859.1.
3D structure databases
SMR	Q319M2. Positions 4-294.
ModBase	Search...
Protein-protein interaction databases
STRING	Q319M2.
Genome annotation databases
GeneID	3766175.
GenomeReviews	Gene locus PMT9312_1363 in contig CP000111_GR.
KEGG	pmi:PMT9312_1363.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
HOGENOM	HBG713904.
OMA	NDGKELA.
Enzyme and pathway databases
BioCyc	PMAR74546:PMT9312_1363-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. ATP_NADK. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPNK2_PROM9

Accession

Primary (citable) accession number: Q319M2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	December 6, 2005
Last modified:	January 19, 2010
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)