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Q319I3 (DDL_PROM9) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:PMT9312_1402
OrganismProchlorococcus marinus (strain MIT 9312) [Complete proteome] [HAMAP]
Taxonomic identifier74546 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_1000030482

Regions

Domain143 – 350208ATP-grasp
Nucleotide binding178 – 23356ATP By similarity

Sites

Metal binding3031Magnesium or manganese 1 By similarity
Metal binding3171Magnesium or manganese 1 By similarity
Metal binding3171Magnesium or manganese 2 By similarity
Metal binding3191Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q319I3 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 74BDBF2551DBE520

FASTA35540,176
        10         20         30         40         50         60 
MIEEKKKCIG LIFGGYSNEH DVSISSAKTV FNAFNSEINK QRFNVKAFYI NKYGDWIDND 

        70         80         90        100        110        120 
ISVKILIGEI EHKKTKKQEL FNQKKINFLD GIEFQNIDIW FPLLHGFNGE DGSIHGLLKF 

       130        140        150        160        170        180 
TNKPLVGCGI LGSALGMDKI LMKTIFSNLK IPQVNYLVIQ NEDLNNLEVK NKLIIEIIKK 

       190        200        210        220        230        240 
LNFPVFVKPS NSGSSLGISK VINKSALLKA LEKAWEIDAR ILVEEGLETR EIECGIIGNS 

       250        260        270        280        290        300 
ELLTSEIGEV EYGSDWYDYD SKYNSNNKIT IPAKIDSKIT KQIKEIAIQS CRTLNIFGFA 

       310        320        330        340        350 
RVDFFLEKSS NKIFLNEINT IPGFTKKSMF PMLWEASGLN IEQLVAKLVD ISLDL 

« Hide

References

[1]"Complete sequence of Prochlorococcus marinus str. MIT 9312."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9312.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000111 Genomic DNA. Translation: ABB50462.1.
RefSeqYP_397898.1. NC_007577.1.

3D structure databases

ProteinModelPortalQ319I3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING74546.PMT9312_1402.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB50462; ABB50462; PMT9312_1402.
GeneID3766216.
KEGGpmi:PMT9312_1402.
PATRIC23006742. VBIProMar70153_1536.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAMDKIAMK.
OrthoDBEOG64BQ73.
ProtClustDBPRK01966.

Enzyme and pathway databases

BioCycPMAR74546:GHRG-1436-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_PROM9
AccessionPrimary (citable) accession number: Q319I3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways