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Q318Q4

- HISX_PROM9

UniProt

Q318Q4 - HISX_PROM9

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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Prochlorococcus marinus (strain MIT 9312)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391NADUniRule annotation
Binding sitei201 – 2011NADUniRule annotation
Binding sitei224 – 2241NADUniRule annotation
Binding sitei247 – 2471SubstrateUniRule annotation
Metal bindingi269 – 2691ZincUniRule annotation
Binding sitei269 – 2691SubstrateUniRule annotation
Metal bindingi272 – 2721ZincUniRule annotation
Binding sitei272 – 2721SubstrateUniRule annotation
Active sitei337 – 3371Proton acceptorUniRule annotation
Active sitei338 – 3381Proton acceptorUniRule annotation
Binding sitei338 – 3381SubstrateUniRule annotation
Metal bindingi371 – 3711ZincUniRule annotation
Binding sitei371 – 3711SubstrateUniRule annotation
Binding sitei425 – 4251SubstrateUniRule annotation
Metal bindingi430 – 4301ZincUniRule annotation
Binding sitei430 – 4301SubstrateUniRule annotation

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciPMAR74546:GHRG-1618-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:PMT9312_1581
OrganismiProchlorococcus marinus (strain MIT 9312)
Taxonomic identifieri74546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002715: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Histidinol dehydrogenasePRO_0000229861Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74546.PMT9312_1581.

Structurei

3D structure databases

ProteinModelPortaliQ318Q4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q318Q4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGREPFNLKN LEMRIINNKK DAIQELKRIS SRTNSENNNK INLIVEEILQ
60 70 80 90 100
EVKTYGDIAV EKYTKKFDGF NPDPMQISED HLKDAWDEID SNLKRSLEVA
110 120 130 140 150
HKRIKKFHEK EIPQSFTIKG EHGDTVQRRW RPVKNAGIYI PGGRAAYPST
160 170 180 190 200
VLMNAIPAKV AGVEEIIMVS PGNKEGEINK TVLAAAHLSG IKKVFRIGGA
210 220 230 240 250
QAIGALAFGT NQINKVDVIT GPGNIYVTTA KKLIYGSTGI DSLAGPSEIL
260 270 280 290 300
VIADETAQST HIASDLLAQA EHDPLASSIL LTTSKNQAKE VLEELYKKID
310 320 330 340 350
DHPRKEICMQ SIKNWGLIVI CENYELCIEL SNNFAPEHLE ILALDSKKIL
360 370 380 390 400
EGIENAGAIF LGKWTPEAVG DYLAGPNHTL PTSGNSRFSG SLGVETFMKN
410 420 430 440
TSIIEFNEES LKVNSLDIIN LAESEGLHSH ANSVKIRFED
Length:440
Mass (Da):48,592
Last modified:December 6, 2005 - v1
Checksum:i5D93F6C85EBF6D0F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000111 Genomic DNA. Translation: ABB50641.1.
RefSeqiWP_011377123.1. NC_007577.1.
YP_398077.1. NC_007577.1.

Genome annotation databases

EnsemblBacteriaiABB50641; ABB50641; PMT9312_1581.
GeneIDi3766398.
KEGGipmi:PMT9312_1581.
PATRICi23007178. VBIProMar70153_1752.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000111 Genomic DNA. Translation: ABB50641.1 .
RefSeqi WP_011377123.1. NC_007577.1.
YP_398077.1. NC_007577.1.

3D structure databases

ProteinModelPortali Q318Q4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 74546.PMT9312_1581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB50641 ; ABB50641 ; PMT9312_1581 .
GeneIDi 3766398.
KEGGi pmi:PMT9312_1581.
PATRICi 23007178. VBIProMar70153_1752.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci PMAR74546:GHRG-1618-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Prochlorococcus marinus str. MIT 9312."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9312.

Entry informationi

Entry nameiHISX_PROM9
AccessioniPrimary (citable) accession number: Q318Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 6, 2005
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3