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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Prochlorococcus marinus (strain MIT 9312)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Proton acceptorUniRule annotation1
Binding sitei126SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:PMT9312_1582
OrganismiProchlorococcus marinus (strain MIT 9312)
Taxonomic identifieri74546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002715 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000169591 – 237Ribose-5-phosphate isomerase AAdd BLAST237

Proteomic databases

PRIDEiQ318Q3

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi74546.PMT9312_1582

Structurei

3D structure databases

ProteinModelPortaliQ318Q3
SMRiQ318Q3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 32Substrate bindingUniRule annotation4
Regioni86 – 89Substrate bindingUniRule annotation4
Regioni99 – 102Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66 Bacteria
COG0120 LUCA
HOGENOMiHOG000276369
KOiK01807
OMAiVAPMAYV
OrthoDBiPOG091H059I

Family and domain databases

CDDicd01398 RPI_A, 1 hit
HAMAPiMF_00170 Rib_5P_isom_A, 1 hit
InterProiView protein in InterPro
IPR037171 NagB/RpiA_transferase-like
IPR004788 Ribose5P_isomerase_typA
IPR020672 Ribose5P_isomerase_typA_subgr
PfamiView protein in Pfam
PF06026 Rib_5-P_isom_A, 1 hit
SUPFAMiSSF100950 SSF100950, 1 hit
TIGRFAMsiTIGR00021 rpiA, 1 hit

Sequencei

Sequence statusi: Complete.

Q318Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQTQMKQI VAEAAIEEVK SDMILGLGSG STAVLMIKSL ADAIRSGKLQ
60 70 80 90 100
NIKGVATSFQ SEVLALELDI PLIDLASVSQ IDLAIDGADE VDPGFQLIKG
110 120 130 140 150
GGACHVREKL VASKANQLLI VVDETKLVRK LNQSFPLPVE VLPNAWKQVQ
160 170 180 190 200
EVISEMNGIS TLRMATKKAG PVVTDQGNLI LDVLFNDGIK NPKDIEKSIN
210 220 230
NIPGVLENGL FIDLTDKVLV GKIENNIPVA YSPAKVG
Length:237
Mass (Da):25,334
Last modified:December 6, 2005 - v1
Checksum:iDB4268BA5E05172E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000111 Genomic DNA Translation: ABB50642.1

Genome annotation databases

EnsemblBacteriaiABB50642; ABB50642; PMT9312_1582
KEGGipmi:PMT9312_1582

Similar proteinsi

Entry informationi

Entry nameiRPIA_PROM9
AccessioniPrimary (citable) accession number: Q318Q3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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