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Protein

Ribose-5-phosphate isomerase A

Gene

rpiA

Organism
Prochlorococcus marinus (strain MIT 9312)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.UniRule annotation

Catalytic activityi

D-ribose 5-phosphate = D-ribulose 5-phosphate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Ribose-5-phosphate isomerase A (rpiA)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081Proton acceptorUniRule annotation
Binding sitei126 – 1261SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciPMAR74546:GHRG-1619-MONOMER.
UniPathwayiUPA00115; UER00412.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribose-5-phosphate isomerase AUniRule annotation (EC:5.3.1.6UniRule annotation)
Alternative name(s):
Phosphoriboisomerase AUniRule annotation
Short name:
PRIUniRule annotation
Gene namesi
Name:rpiAUniRule annotation
Ordered Locus Names:PMT9312_1582
OrganismiProchlorococcus marinus (strain MIT 9312)
Taxonomic identifieri74546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
Proteomesi
  • UP000002715 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Ribose-5-phosphate isomerase APRO_1000016959Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi74546.PMT9312_1582.

Structurei

3D structure databases

ProteinModelPortaliQ318Q3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 324Substrate bindingUniRule annotation
Regioni86 – 894Substrate bindingUniRule annotation
Regioni99 – 1024Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ribose 5-phosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276369.
KOiK01807.
OMAiGACHVQE.
OrthoDBiEOG67MF61.

Family and domain databases

HAMAPiMF_00170. Rib_5P_isom_A.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q318Q3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQTQMKQI VAEAAIEEVK SDMILGLGSG STAVLMIKSL ADAIRSGKLQ
60 70 80 90 100
NIKGVATSFQ SEVLALELDI PLIDLASVSQ IDLAIDGADE VDPGFQLIKG
110 120 130 140 150
GGACHVREKL VASKANQLLI VVDETKLVRK LNQSFPLPVE VLPNAWKQVQ
160 170 180 190 200
EVISEMNGIS TLRMATKKAG PVVTDQGNLI LDVLFNDGIK NPKDIEKSIN
210 220 230
NIPGVLENGL FIDLTDKVLV GKIENNIPVA YSPAKVG
Length:237
Mass (Da):25,334
Last modified:December 6, 2005 - v1
Checksum:iDB4268BA5E05172E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000111 Genomic DNA. Translation: ABB50642.1.

Genome annotation databases

EnsemblBacteriaiABB50642; ABB50642; PMT9312_1582.
KEGGipmi:PMT9312_1582.
PATRICi23007180. VBIProMar70153_1753.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000111 Genomic DNA. Translation: ABB50642.1.

3D structure databases

ProteinModelPortaliQ318Q3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi74546.PMT9312_1582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB50642; ABB50642; PMT9312_1582.
KEGGipmi:PMT9312_1582.
PATRICi23007180. VBIProMar70153_1753.

Phylogenomic databases

eggNOGiENOG4105E66. Bacteria.
COG0120. LUCA.
HOGENOMiHOG000276369.
KOiK01807.
OMAiGACHVQE.
OrthoDBiEOG67MF61.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00412.
BioCyciPMAR74546:GHRG-1619-MONOMER.

Family and domain databases

HAMAPiMF_00170. Rib_5P_isom_A.
InterProiIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERiPTHR11934. PTHR11934. 1 hit.
PfamiPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00021. rpiA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Prochlorococcus marinus str. MIT 9312."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9312.

Entry informationi

Entry nameiRPIA_PROM9
AccessioniPrimary (citable) accession number: Q318Q3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: November 11, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.