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Q318F2

- PANCY_PROM9

UniProt

Q318F2 - PANCY_PROM9

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Protein
Bifunctional pantoate ligase/cytidylate kinase
Gene
panC/cmk, PMT9312_1682
Organism
Prochlorococcus marinus (strain MIT 9312)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi289 – 2979ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. cytidylate kinase activity Source: UniProtKB-HAMAP
  3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
  2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Ligase, Transferase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR74546:GHRG-1725-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional pantoate ligase/cytidylate kinase
Including the following 2 domains:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Cytidylate kinase (EC:2.7.4.14)
Short name:
CK
Alternative name(s):
Cytidine monophosphate kinase
Short name:
CMP kinase
Gene namesi
Name:panC/cmk
Ordered Locus Names:PMT9312_1682
OrganismiProchlorococcus marinus (strain MIT 9312)
Taxonomic identifieri74546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002715: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
PRO_0000239789Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi74546.PMT9312_1682.

Structurei

3D structure databases

ProteinModelPortaliQ318F2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 276276Pantoate--beta-alanine ligaseUniRule annotation
Add
BLAST
Regioni277 – 510234Cytidylate kinaseUniRule annotation
Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the pantothenate synthetase family.
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.

Phylogenomic databases

eggNOGiCOG0283.
HOGENOMiHOG000233355.
KOiK13799.
OMAiLGEKDWQ.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
PfamiPF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q318F2-1 [UniParc]FASTAAdd to Basket

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MKKVIIRKTE EIKNWRRNIN SDINFIPTMG NLHNGHKTLI STAKNANSNV    50
NLVSIFVNPL QFDNKSDLEN YPKTIDNDIK ISFENGADVI FIPSTEEIYP 100
SDNKNITFLK APLELSSSLC GLNRIGHFDG VCTVVYKLLN LIKPKNLYLG 150
EKDWQQLLIL KNLVLTKKLD VAIKSIPTQR DFDGIPLSSR NVHLSNNERK 200
LIRFFSHELL VAKENFQQEK KINLKEIIQK LSAQKISIEY LEHLHPYTLQ 250
ESKVEDNISI LAGAIRCGET RLIDHVFLMK RSPIIAIDGP AGSGKSTVTQ 300
LIAKKLKLLY LDTGAMYRAL SWLLIKENID YKEEKKLQNI LKDISIVFKS 350
NTNSQQDVFI NNYCVTEEIR SQEISSIVSK ISSIKEVREF LVEEQRKIGE 400
SGGLVAEGRD IGTTVFPDAE LKIFLTASID ERAKRRKSDK KSKDSQEIDL 450
HKLKELIKKR DFEDSNREIS PLIKANDAIE IITDGCSINE VVDKIIDLYN 500
DKIPKETQIR 510
Length:510
Mass (Da):58,205
Last modified:December 6, 2005 - v1
Checksum:i3F9FC5D467800741
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000111 Genomic DNA. Translation: ABB50743.1.
RefSeqiWP_011377224.1. NC_007577.1.
YP_398179.1. NC_007577.1.

Genome annotation databases

EnsemblBacteriaiABB50743; ABB50743; PMT9312_1682.
GeneIDi3766505.
KEGGipmi:PMT9312_1682.
PATRICi23007396. VBIProMar70153_1856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000111 Genomic DNA. Translation: ABB50743.1 .
RefSeqi WP_011377224.1. NC_007577.1.
YP_398179.1. NC_007577.1.

3D structure databases

ProteinModelPortali Q318F2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 74546.PMT9312_1682.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB50743 ; ABB50743 ; PMT9312_1682 .
GeneIDi 3766505.
KEGGi pmi:PMT9312_1682.
PATRICi 23007396. VBIProMar70153_1856.

Phylogenomic databases

eggNOGi COG0283.
HOGENOMi HOG000233355.
KOi K13799.
OMAi LGEKDWQ.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci PMAR74546:GHRG-1725-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
MF_00238. Cytidyl_kinase_type1.
MF_01349. PanCY.
InterProi IPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
IPR003721. Pantoate_ligase.
IPR024894. Pantoate_ligase/cytidylate_kin.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
Pfami PF02224. Cytidylate_kin. 1 hit.
PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00017. cmk. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Prochlorococcus marinus str. MIT 9312."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Thiel J., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9312.

Entry informationi

Entry nameiPANCY_PROM9
AccessioniPrimary (citable) accession number: Q318F2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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