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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi249Magnesium or manganese 11
Metal bindingi262Magnesium or manganese 11
Metal bindingi262Magnesium or manganese 21
Metal bindingi264Magnesium or manganese 21

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi127 – 180ATPAdd BLAST54

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligase (EC:6.3.2.4)
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene namesi
Name:ddl
Ordered Locus Names:Dde_0366
OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Taxonomic identifieri207559 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002710 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000304451 – 308D-alanine--D-alanine ligaseAdd BLAST308

Interactioni

Protein-protein interaction databases

STRINGi207559.Dde_0366.

Structurei

3D structure databases

ProteinModelPortaliQ316H9.
SMRiQ316H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 295ATP-graspAdd BLAST196

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.

Phylogenomic databases

eggNOGiENOG4105CPF. Bacteria.
COG1181. LUCA.
HOGENOMiHOG000011592.
KOiK01921.
OMAiYETKYTE.
OrthoDBiPOG091H00GT.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom_sf.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q316H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILLIAGGW SEERDVSLSG ARGIHAALER LGHQVTLFDP CRTLAGLLEA
60 70 80 90 100
AQAHDFAFLN LHGQPGEDGL VQALLETAGV PYQGSGPAGS FLALNKAAAK
110 120 130 140 150
EVFVRNGLPT PEWVFLPAHP GADWEPPFAF PAFIKSNNGG SSLALHRVSC
160 170 180 190 200
PGELARALDE LFTRGGEAII EPAVEGVEVT CGVLGDEALP PILIRPLGAG
210 220 230 240 250
FFDYASKYTP GQAEELCPAP LPGEVTAKVR EYALRAHRAL GLRGYSRSDF
260 270 280 290 300
ILTPAGALSL LEVNTLPGMT ATSLLPQEAA AVGISFDGLI GRLIELGLAA

HGKQQEKA
Length:308
Mass (Da):32,382
Last modified:December 6, 2005 - v1
Checksum:i1F7495653E58E589
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000112 Genomic DNA. Translation: ABB37167.1.
RefSeqiWP_011366505.1. NC_007519.1.

Genome annotation databases

EnsemblBacteriaiABB37167; ABB37167; Dde_0366.
KEGGidde:Dde_0366.

Similar proteinsi

Entry informationi

Entry nameiDDL_DESAG
AccessioniPrimary (citable) accession number: Q316H9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: November 22, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families