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Protein

HLA class I histocompatibility antigen, B-73 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-73 alpha chain
Alternative name(s):
MHC class I antigen B*73
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence analysisAdd
BLAST
Transmembranei309 – 33325HelicalSequence analysisAdd
BLAST
Topological domaini334 – 36330CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-B.

Polymorphism and mutation databases

DMDMi34222512.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 363339HLA class I histocompatibility antigen, B-73 alpha chainPRO_0000018864Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

EPDiQ31612.
PeptideAtlasiQ31612.
PRIDEiQ31612.

PTM databases

iPTMnetiQ31612.
PhosphoSiteiQ31612.
SwissPalmiQ31612.

Expressioni

Gene expression databases

BgeeiQ31612.
CleanExiHS_HLA-B.
ExpressionAtlasiQ31612. baseline and differential.
GenevisibleiQ31612. HS.

Organism-specific databases

HPAiCAB015418.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

IntActiQ31612. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ31612.
SMRiQ31612. Positions 25-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29789Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiQ31612.
PhylomeDBiQ31612.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q31612-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVMAPRTVL LLLSAALALT ETWAGSHSMR YFHTSVSRPG RGEPRFITVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI CKAKAQTDRV
110 120 130 140 150
GLRNLRGYYN QSEDGSHTWQ TMYGCDMGPD GRLLRGYNQF AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK WEAARVAEQL RAYLEGECVE WLRRHLENGK
210 220 230 240 250
ETLQRADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL QEPCTLRWKP
310 320 330 340 350
SSQSTIPIVG IVAGLAVLVV TVAVVAVVAA VMCRRKSSGG KGGSYSQAAS
360
SDSAQGSDVS LTA
Length:363
Mass (Da):40,435
Last modified:November 1, 1996 - v1
Checksum:i04522E97C1E11C40
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti338 – 3392SG → C in CAC35319 (PubMed:12622774).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41M → T.
Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
VAR_056430
Natural varianti9 – 91V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
VAR_056431
Natural varianti17 – 171L → V.
Corresponds to variant rs1131165 [ dbSNP | Ensembl ].
VAR_056432
Natural varianti65 – 651A → T.Combined sources
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_056433
Natural varianti87 – 871N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_056434
Natural varianti87 – 871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059496
Natural varianti155 – 1551R → S.Combined sources
Corresponds to variant rs1050654 [ dbSNP | Ensembl ].
VAR_056435

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04787 mRNA. Translation: AAA53175.1.
X77658 mRNA. Translation: CAA54739.1.
L24373 mRNA. Translation: AAA96733.1.
AJ311601 Genomic DNA. Translation: CAC35319.2.
JF974053 Genomic DNA. Translation: AEN79482.1.
PIRiI37512. S42102.
UniGeneiHs.654404.
Hs.77961.

Genome annotation databases

EnsembliENST00000412585; ENSP00000399168; ENSG00000234745.
UCSCiuc003nth.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04787 mRNA. Translation: AAA53175.1.
X77658 mRNA. Translation: CAA54739.1.
L24373 mRNA. Translation: AAA96733.1.
AJ311601 Genomic DNA. Translation: CAC35319.2.
JF974053 Genomic DNA. Translation: AEN79482.1.
PIRiI37512. S42102.
UniGeneiHs.654404.
Hs.77961.

3D structure databases

ProteinModelPortaliQ31612.
SMRiQ31612. Positions 25-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ31612. 1 interaction.

PTM databases

iPTMnetiQ31612.
PhosphoSiteiQ31612.
SwissPalmiQ31612.

Polymorphism and mutation databases

DMDMi34222512.

Proteomic databases

EPDiQ31612.
PeptideAtlasiQ31612.
PRIDEiQ31612.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412585; ENSP00000399168; ENSG00000234745.
UCSCiuc003nth.3. human.

Organism-specific databases

GeneCardsiHLA-B.
HGNCiHGNC:4932. HLA-B.
HPAiCAB015418.
MalaCardsiHLA-B.
MIMi142830. gene.
neXtProtiNX_Q31612.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiQ31612.
PhylomeDBiQ31612.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-B. human.
SOURCEiSearch...

Gene expression databases

BgeeiQ31612.
CleanExiHS_HLA-B.
ExpressionAtlasiQ31612. baseline and differential.
GenevisibleiQ31612. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The HLA-B73 antigen has a most unusual structure that defines a second lineage of HLA-B alleles."
    Parham P., Arnett K.L., Adams E.J., Barber L.D., Domena J.D., Stewart D., Hildebrand W.H., Little A.-M.
    Tissue Antigens 43:302-313(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*73:01).
  2. "HLA-B73: an atypical HLA-B molecule carrying a Bw6-epitope motif variant and a B pocket identical to HLA-B27."
    Vilches C., de Pablo R., Herrero M.J., Moreno M.E., Kreisler M.
    Immunogenetics 40:166-166(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*73:01).
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*73:01).
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*73:01).
    Tissue: Blood.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE B*73:01).
  6. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-155, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1B73_HUMAN
AccessioniPrimary (citable) accession number: Q31612
Secondary accession number(s): G3GN01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.