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Q31610

- 1B81_HUMAN

UniProt

Q31610 - 1B81_HUMAN

Protein

HLA class I histocompatibility antigen, B-81 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.

    GO - Molecular functioni

    1. peptide antigen binding Source: UniProt

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
    3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
    4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
    5. cytokine-mediated signaling pathway Source: Reactome
    6. interferon-gamma-mediated signaling pathway Source: Reactome
    7. positive regulation of T cell mediated cytotoxicity Source: InterPro
    8. regulation of immune response Source: Reactome
    9. type I interferon signaling pathway Source: Reactome
    10. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Immunity

    Enzyme and pathway databases

    ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class I histocompatibility antigen, B-81 alpha chain
    Alternative name(s):
    B'DT
    MHC class I antigen B*81
    Gene namesi
    Name:HLA-B
    Synonyms:HLAB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4932. HLA-B.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: UniProt
    2. early endosome membrane Source: Reactome
    3. endoplasmic reticulum Source: UniProt
    4. ER to Golgi transport vesicle membrane Source: Reactome
    5. Golgi apparatus Source: UniProt
    6. Golgi membrane Source: Reactome
    7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    8. MHC class I protein complex Source: UniProt
    9. phagocytic vesicle membrane Source: Reactome
    10. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane, MHC I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Add
    BLAST
    Chaini25 – 362338HLA class I histocompatibility antigen, B-81 alpha chainPRO_0000018866Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi110 – 1101N-linked (GlcNAc...)By similarity
    Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
    Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

    Post-translational modificationi

    Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Ubl conjugation

    Proteomic databases

    PRIDEiQ31610.

    Expressioni

    Gene expression databases

    ArrayExpressiQ31610.
    BgeeiQ31610.
    CleanExiHS_HLA-B.
    GenevestigatoriQ31610.

    Organism-specific databases

    HPAiCAB015418.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ31610.
    SMRiQ31610. Positions 25-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 308284ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 36230CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei309 – 33224HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini209 – 29587Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni25 – 11490Alpha-1Add
    BLAST
    Regioni115 – 20692Alpha-2Add
    BLAST
    Regioni207 – 29892Alpha-3Add
    BLAST
    Regioni299 – 30810Connecting peptide

    Sequence similaritiesi

    Belongs to the MHC class I family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG016709.
    TreeFamiTF336617.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q31610-1 [UniParc]FASTAAdd to Basket

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    MLVMAPRTVL LLLWGAVALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG    50
    YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE 100
    SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL 150
    NEDLRSWTAA DTAAQISQRK LEAARVAEQL RAYLEGECVE WLRRYLENGK 200
    DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
    DTELVETRPA GDRTFQKWTA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 300
    SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS 350
    DSAQGSDVSL TA 362
    Length:362
    Mass (Da):40,400
    Last modified:November 1, 1996 - v1
    Checksum:iCB2660A583C8A0D8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41M → T.
    Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
    VAR_056437
    Natural varianti9 – 91V → L.
    Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
    VAR_056438
    Natural varianti35 – 351S → A.
    Corresponds to variant rs1131170 [ dbSNP | Ensembl ].
    VAR_056439
    Natural varianti36 – 361V → M.
    Corresponds to variant rs1050486 [ dbSNP | Ensembl ].
    VAR_056440
    Natural varianti48 – 481S → A.
    Corresponds to variant rs713031 [ dbSNP | Ensembl ].
    VAR_061436
    Natural varianti48 – 481S → P.
    Corresponds to variant rs713031 [ dbSNP | Ensembl ].
    VAR_061437
    Natural varianti48 – 481S → T.
    Corresponds to variant rs713031 [ dbSNP | Ensembl ].
    VAR_061438
    Natural varianti65 – 651A → T.1 Publication
    Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
    VAR_056441
    Natural varianti87 – 871N → D.
    Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
    VAR_056442
    Natural varianti87 – 871N → K.
    Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
    VAR_059497
    Natural varianti97 – 971T → A.
    Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
    VAR_056443
    Natural varianti98 – 981D → Y.
    Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
    VAR_059498
    Natural varianti101 – 1011S → N.
    Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
    VAR_056444
    Natural varianti137 – 1371H → Y.
    Corresponds to variant rs1050379 [ dbSNP | Ensembl ].
    VAR_056445
    Natural varianti155 – 1551R → S.
    Corresponds to variant rs1050654 [ dbSNP | Ensembl ].
    VAR_056446
    Natural varianti187 – 1871E → A.
    Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
    VAR_059499
    Natural varianti187 – 1871E → G.
    Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
    VAR_059500
    Natural varianti187 – 1871E → K.
    Corresponds to variant rs2523600 [ dbSNP | Ensembl ].
    VAR_059501
    Natural varianti187 – 1871E → Q.
    Corresponds to variant rs2523600 [ dbSNP | Ensembl ].
    VAR_059502
    Natural varianti187 – 1871E → V.
    Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
    VAR_059503
    Natural varianti195 – 1951Y → H.
    Corresponds to variant rs1050696 [ dbSNP | Ensembl ].
    VAR_056447
    Natural varianti306 – 3061V → I.
    Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
    VAR_056448
    Natural varianti329 – 3291A → T.
    Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
    VAR_056449
    Natural varianti349 – 3491C → S.
    Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
    VAR_061439
    Natural varianti349 – 3491C → Y.
    Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
    VAR_061440

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37880 mRNA. Translation: AAC41941.1.
    X90390 mRNA. Translation: CAA62035.1.
    U09912 mRNA. Translation: AAF70855.1.
    UniGeneiHs.654404.
    Hs.77961.

    Genome annotation databases

    EnsembliENST00000412585; ENSP00000399168; ENSG00000234745.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37880 mRNA. Translation: AAC41941.1 .
    X90390 mRNA. Translation: CAA62035.1 .
    U09912 mRNA. Translation: AAF70855.1 .
    UniGenei Hs.654404.
    Hs.77961.

    3D structure databases

    ProteinModelPortali Q31610.
    SMRi Q31610. Positions 25-299.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q31610.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000412585 ; ENSP00000399168 ; ENSG00000234745 .

    Organism-specific databases

    GeneCardsi GC06M031321.
    HGNCi HGNC:4932. HLA-B.
    HPAi CAB015418.
    MIMi 142830. gene.
    neXtProti NX_Q31610.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG016709.
    TreeFami TF336617.

    Enzyme and pathway databases

    Reactomei REACT_111168. Endosomal/Vacuolar pathway.
    REACT_111178. ER-Phagosome pathway.
    REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_25078. Interferon gamma signaling.
    REACT_25162. Interferon alpha/beta signaling.
    REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

    Miscellaneous databases

    ChiTaRSi HLA-B. human.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q31610.
    Bgeei Q31610.
    CleanExi HS_HLA-B.
    Genevestigatori Q31610.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence analysis of HLA-B*1523 and B*8101. Dominant alpha-helical motifs produce complex serologic recognition patterns for the HLA-B''DT'' and HLA-B''NM5'' antigens."
      Ellexson M.E., Zhang G., Stewart D., Lau M., Teresi G., Terasaki P., Roe B.A., Hildebrand W.H.
      Hum. Immunol. 44:103-110(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*81:01).
    2. "Molecular characterization of the new alleles HLA-B*8101 and B*4407."
      Vilches C., Sanz L., de Pablo R., Moreno M.E., Puente S., Kreisler M.
      Tissue Antigens 47:139-142(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*81:01).
    3. "HLA-B'DT', a class I allele most homologous with HLA-B-4801."
      Hildebrand W.H., Ellexson M.E.
      Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*81:01).
    4. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry namei1B81_HUMAN
    AccessioniPrimary (citable) accession number: Q31610
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3