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Protein

HLA class I histocompatibility antigen, B-81 alpha chain

Gene

HLA-B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-81 alpha chain
Alternative name(s):
B'DT
MHC class I antigen B*81
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 308ExtracellularSequence analysisAdd BLAST284
Transmembranei309 – 332HelicalSequence analysisAdd BLAST24
Topological domaini333 – 362CytoplasmicSequence analysisAdd BLAST30

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Add BLAST24
ChainiPRO_000001886625 – 362HLA class I histocompatibility antigen, B-81 alpha chainAdd BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...)By similarity1
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ31610.
PaxDbiQ31610.
PeptideAtlasiQ31610.
PRIDEiQ31610.

PTM databases

SwissPalmiQ31610.

Expressioni

Gene expression databases

BgeeiENSG00000234745.
CleanExiHS_HLA-B.
ExpressionAtlasiQ31610. baseline and differential.
GenevisibleiQ31610. HS.

Organism-specific databases

HPAiCAB015418.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000399168.

Structurei

Secondary structure

1362
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi27 – 36Combined sources10
Beta strandi41 – 43Combined sources3
Beta strandi45 – 52Combined sources8
Beta strandi55 – 61Combined sources7
Beta strandi64 – 66Combined sources3
Helixi74 – 76Combined sources3
Helixi81 – 108Combined sources28
Beta strandi113 – 115Combined sources3
Beta strandi118 – 127Combined sources10
Beta strandi133 – 142Combined sources10
Beta strandi145 – 150Combined sources6
Beta strandi157 – 161Combined sources5
Helixi162 – 173Combined sources12
Helixi176 – 185Combined sources10
Helixi187 – 197Combined sources11
Helixi200 – 203Combined sources4
Beta strandi210 – 217Combined sources8
Beta strandi219 – 235Combined sources17
Beta strandi238 – 243Combined sources6
Beta strandi246 – 248Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Turni275 – 277Combined sources3
Helixi278 – 280Combined sources3
Beta strandi281 – 286Combined sources6
Beta strandi294 – 296Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4U1IX-ray1.92A25-301[»]
4U1LX-ray2.06A/D25-300[»]
4U1SX-ray1.76A25-301[»]
ProteinModelPortaliQ31610.
SMRiQ31610.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 295Ig-like C1-typeAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni25 – 114Alpha-1Add BLAST90
Regioni115 – 206Alpha-2Add BLAST92
Regioni207 – 298Alpha-3Add BLAST92
Regioni299 – 308Connecting peptide10

Sequence similaritiesi

Belongs to the MHC class I family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.
OrthoDBiEOG091G09OH.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q31610-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVMAPRTVL LLLWGAVALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE
110 120 130 140 150
SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQISQRK LEAARVAEQL RAYLEGECVE WLRRYLENGK
210 220 230 240 250
DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDRTFQKWTA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS
360
DSAQGSDVSL TA
Length:362
Mass (Da):40,400
Last modified:November 1, 1996 - v1
Checksum:iCB2660A583C8A0D8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0564374M → T.Corresponds to variant rs1050458dbSNPEnsembl.1
Natural variantiVAR_0564389V → L.Corresponds to variant rs1050462dbSNPEnsembl.1
Natural variantiVAR_05643935S → A.Corresponds to variant rs1131170dbSNPEnsembl.1
Natural variantiVAR_05644036V → M.Corresponds to variant rs1050486dbSNPEnsembl.1
Natural variantiVAR_06143648S → A.Corresponds to variant rs713031dbSNPEnsembl.1
Natural variantiVAR_06143748S → P.Corresponds to variant rs713031dbSNPEnsembl.1
Natural variantiVAR_06143848S → T.Corresponds to variant rs713031dbSNPEnsembl.1
Natural variantiVAR_05644165A → T.Combined sourcesCorresponds to variant rs1050529dbSNPEnsembl.1
Natural variantiVAR_05644287N → D.Corresponds to variant rs1050570dbSNPEnsembl.1
Natural variantiVAR_05949787N → K.Corresponds to variant rs1065386dbSNPEnsembl.1
Natural variantiVAR_05644397T → A.Corresponds to variant rs1050393dbSNPEnsembl.1
Natural variantiVAR_05949898D → Y.Corresponds to variant rs1131215dbSNPEnsembl.1
Natural variantiVAR_056444101S → N.Corresponds to variant rs1050388dbSNPEnsembl.1
Natural variantiVAR_056445137H → Y.Corresponds to variant rs1050379dbSNPEnsembl.1
Natural variantiVAR_056446155R → S.Corresponds to variant rs1050654dbSNPEnsembl.1
Natural variantiVAR_059499187E → A.Corresponds to variant rs2308466dbSNPEnsembl.1
Natural variantiVAR_059500187E → G.Corresponds to variant rs2308466dbSNPEnsembl.1
Natural variantiVAR_059501187E → K.Corresponds to variant rs2523600dbSNPEnsembl.1
Natural variantiVAR_059502187E → Q.Corresponds to variant rs2523600dbSNPEnsembl.1
Natural variantiVAR_059503187E → V.Corresponds to variant rs2308466dbSNPEnsembl.1
Natural variantiVAR_056447195Y → H.Corresponds to variant rs1050696dbSNPEnsembl.1
Natural variantiVAR_056448306V → I.Corresponds to variant rs1131500dbSNPEnsembl.1
Natural variantiVAR_056449329A → T.Corresponds to variant rs1051488dbSNPEnsembl.1
Natural variantiVAR_061439349C → S.Corresponds to variant rs2308655dbSNPEnsembl.1
Natural variantiVAR_061440349C → Y.Corresponds to variant rs2308655dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37880 mRNA. Translation: AAC41941.1.
X90390 mRNA. Translation: CAA62035.1.
U09912 mRNA. Translation: AAF70855.1.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

Genome annotation databases

EnsembliENST00000412585; ENSP00000399168; ENSG00000234745.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37880 mRNA. Translation: AAC41941.1.
X90390 mRNA. Translation: CAA62035.1.
U09912 mRNA. Translation: AAF70855.1.
UniGeneiHs.654404.
Hs.726974.
Hs.77961.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4U1IX-ray1.92A25-301[»]
4U1LX-ray2.06A/D25-300[»]
4U1SX-ray1.76A25-301[»]
ProteinModelPortaliQ31610.
SMRiQ31610.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000399168.

PTM databases

SwissPalmiQ31610.

Proteomic databases

MaxQBiQ31610.
PaxDbiQ31610.
PeptideAtlasiQ31610.
PRIDEiQ31610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412585; ENSP00000399168; ENSG00000234745.

Organism-specific databases

GeneCardsiHLA-B.
HGNCiHGNC:4932. HLA-B.
HPAiCAB015418.
MalaCardsiHLA-B.
MIMi142830. gene.
neXtProtiNX_Q31610.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5V. Eukaryota.
ENOG4111K8F. LUCA.
HOVERGENiHBG016709.
OrthoDBiEOG091G09OH.
TreeFamiTF336617.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-B. human.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000234745.
CleanExiHS_HLA-B.
ExpressionAtlasiQ31610. baseline and differential.
GenevisibleiQ31610. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1B81_HUMAN
AccessioniPrimary (citable) accession number: Q31610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.