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Q31610 (1B81_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HLA class I histocompatibility antigen, B-81 alpha chain
Alternative name(s):
B'DT
MHC class I antigen B*81
Gene names
Name:HLA-B
Synonyms:HLAB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system.

Subunit structure

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processHost-virus interaction
Immunity
   Cellular componentMembrane
MHC I
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Ubl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: InterPro

regulation of immune response

Traceable author statement. Source: Reactome

type I interferon signaling pathway

Traceable author statement. Source: Reactome

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi apparatus

Inferred from sequence or structural similarity. Source: UniProt

Golgi membrane

Traceable author statement. Source: Reactome

MHC class I protein complex

Inferred from sequence or structural similarity. Source: UniProt

cell surface

Inferred from sequence or structural similarity. Source: UniProt

early endosome membrane

Traceable author statement. Source: Reactome

endoplasmic reticulum

Inferred from sequence or structural similarity. Source: UniProt

integral component of lumenal side of endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

phagocytic vesicle membrane

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionpeptide antigen binding

Inferred from sequence or structural similarity. Source: UniProt

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 362338HLA class I histocompatibility antigen, B-81 alpha chain
PRO_0000018866

Regions

Topological domain25 – 308284Extracellular Potential
Transmembrane309 – 33224Helical; Potential
Topological domain333 – 36230Cytoplasmic Potential
Domain209 – 29587Ig-like C1-type
Region25 – 11490Alpha-1
Region115 – 20692Alpha-2
Region207 – 29892Alpha-3
Region299 – 30810Connecting peptide

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) By similarity
Disulfide bond125 ↔ 188 By similarity
Disulfide bond227 ↔ 283 By similarity

Natural variations

Natural variant41M → T.
Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
VAR_056437
Natural variant91V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
VAR_056438
Natural variant351S → A.
Corresponds to variant rs1131170 [ dbSNP | Ensembl ].
VAR_056439
Natural variant361V → M.
Corresponds to variant rs1050486 [ dbSNP | Ensembl ].
VAR_056440
Natural variant481S → A.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061436
Natural variant481S → P.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061437
Natural variant481S → T.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061438
Natural variant651A → T. Ref.4
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_056441
Natural variant871N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_056442
Natural variant871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059497
Natural variant971T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
VAR_056443
Natural variant981D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
VAR_059498
Natural variant1011S → N.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
VAR_056444
Natural variant1371H → Y.
Corresponds to variant rs1050379 [ dbSNP | Ensembl ].
VAR_056445
Natural variant1551R → S.
Corresponds to variant rs1050654 [ dbSNP | Ensembl ].
VAR_056446
Natural variant1871E → A.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
VAR_059499
Natural variant1871E → G.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
VAR_059500
Natural variant1871E → K.
Corresponds to variant rs2523600 [ dbSNP | Ensembl ].
VAR_059501
Natural variant1871E → Q.
Corresponds to variant rs2523600 [ dbSNP | Ensembl ].
VAR_059502
Natural variant1871E → V.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
VAR_059503
Natural variant1951Y → H.
Corresponds to variant rs1050696 [ dbSNP | Ensembl ].
VAR_056447
Natural variant3061V → I.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
VAR_056448
Natural variant3291A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
VAR_056449
Natural variant3491C → S.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061439
Natural variant3491C → Y.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061440

Sequences

Sequence LengthMass (Da)Tools
Q31610 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: CB2660A583C8A0D8

FASTA36240,400
        10         20         30         40         50         60 
MLVMAPRTVL LLLWGAVALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE SLRNLRGYYN QSEAGSHTLQ 

       130        140        150        160        170        180 
SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL NEDLRSWTAA DTAAQISQRK LEAARVAEQL 

       190        200        210        220        230        240 
RAYLEGECVE WLRRYLENGK DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDRTFQKWTA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS DSAQGSDVSL 


TA 

« Hide

References

« Hide 'large scale' references
[1]"Nucleotide sequence analysis of HLA-B*1523 and B*8101. Dominant alpha-helical motifs produce complex serologic recognition patterns for the HLA-B''DT'' and HLA-B''NM5'' antigens."
Ellexson M.E., Zhang G., Stewart D., Lau M., Teresi G., Terasaki P., Roe B.A., Hildebrand W.H.
Hum. Immunol. 44:103-110(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*81:01).
[2]"Molecular characterization of the new alleles HLA-B*8101 and B*4407."
Vilches C., Sanz L., de Pablo R., Moreno M.E., Puente S., Kreisler M.
Tissue Antigens 47:139-142(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*81:01).
[3]"HLA-B'DT', a class I allele most homologous with HLA-B-4801."
Hildebrand W.H., Ellexson M.E.
Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*81:01).
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L37880 mRNA. Translation: AAC41941.1.
X90390 mRNA. Translation: CAA62035.1.
U09912 mRNA. Translation: AAF70855.1.
UniGeneHs.654404.
Hs.77961.

3D structure databases

ProteinModelPortalQ31610.
SMRQ31610. Positions 25-299.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ31610.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000412585; ENSP00000399168; ENSG00000234745.

Organism-specific databases

GeneCardsGC06M031321.
HGNCHGNC:4932. HLA-B.
HPACAB015418.
MIM142830. gene.
neXtProtNX_Q31610.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG016709.
TreeFamTF336617.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressQ31610.
BgeeQ31610.
CleanExHS_HLA-B.
GenevestigatorQ31610.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-B. human.
SOURCESearch...

Entry information

Entry name1B81_HUMAN
AccessionPrimary (citable) accession number: Q31610
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

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List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM