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Q31610

- 1B81_HUMAN

UniProt

Q31610 - 1B81_HUMAN

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Protein

HLA class I histocompatibility antigen, B-81 alpha chain

Gene
HLA-B, HLAB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  1. peptide antigen binding Source: UniProt

GO - Biological processi

  1. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: Reactome
  2. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
  3. antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
  4. antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
  5. cytokine-mediated signaling pathway Source: Reactome
  6. interferon-gamma-mediated signaling pathway Source: Reactome
  7. positive regulation of T cell mediated cytotoxicity Source: InterPro
  8. regulation of immune response Source: Reactome
  9. type I interferon signaling pathway Source: Reactome
  10. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiREACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, B-81 alpha chain
Alternative name(s):
B'DT
MHC class I antigen B*81
Gene namesi
Name:HLA-B
Synonyms:HLAB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:4932. HLA-B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284Extracellular Reviewed predictionAdd
BLAST
Transmembranei309 – 33224Helical; Reviewed predictionAdd
BLAST
Topological domaini333 – 36230Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: UniProt
  2. early endosome membrane Source: Reactome
  3. endoplasmic reticulum Source: UniProt
  4. ER to Golgi transport vesicle membrane Source: Reactome
  5. Golgi apparatus Source: UniProt
  6. Golgi membrane Source: Reactome
  7. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
  8. MHC class I protein complex Source: UniProt
  9. phagocytic vesicle membrane Source: Reactome
  10. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 362338HLA class I histocompatibility antigen, B-81 alpha chainPRO_0000018866Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...) By similarity
Disulfide bondi125 ↔ 188 By similarity
Disulfide bondi227 ↔ 283 By similarity

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ31610.

Expressioni

Gene expression databases

ArrayExpressiQ31610.
BgeeiQ31610.
CleanExiHS_HLA-B.
GenevestigatoriQ31610.

Organism-specific databases

HPAiCAB015418.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ31610.
SMRiQ31610. Positions 25-299.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q31610-1 [UniParc]FASTAAdd to Basket

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MLVMAPRTVL LLLWGAVALT ETWAGSHSMR YFYTSVSRPG RGEPRFISVG    50
YVDDTQFVRF DSDAASPREE PRAPWIEQEG PEYWDRNTQI YKAQAQTDRE 100
SLRNLRGYYN QSEAGSHTLQ SMYGCDVGPD GRLLRGHNQY AYDGKDYIAL 150
NEDLRSWTAA DTAAQISQRK LEAARVAEQL RAYLEGECVE WLRRYLENGK 200
DKLERADPPK THVTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
DTELVETRPA GDRTFQKWTA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 300
SSQSTVPIVG IVAGLAVLAV VVIGAVVAAV MCRRKSSGGK GGSYSQAACS 350
DSAQGSDVSL TA 362
Length:362
Mass (Da):40,400
Last modified:November 1, 1996 - v1
Checksum:iCB2660A583C8A0D8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41M → T.
Corresponds to variant rs1050458 [ dbSNP | Ensembl ].
VAR_056437
Natural varianti9 – 91V → L.
Corresponds to variant rs1050462 [ dbSNP | Ensembl ].
VAR_056438
Natural varianti35 – 351S → A.
Corresponds to variant rs1131170 [ dbSNP | Ensembl ].
VAR_056439
Natural varianti36 – 361V → M.
Corresponds to variant rs1050486 [ dbSNP | Ensembl ].
VAR_056440
Natural varianti48 – 481S → A.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061436
Natural varianti48 – 481S → P.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061437
Natural varianti48 – 481S → T.
Corresponds to variant rs713031 [ dbSNP | Ensembl ].
VAR_061438
Natural varianti65 – 651A → T.1 Publication
Corresponds to variant rs1050529 [ dbSNP | Ensembl ].
VAR_056441
Natural varianti87 – 871N → D.
Corresponds to variant rs1050570 [ dbSNP | Ensembl ].
VAR_056442
Natural varianti87 – 871N → K.
Corresponds to variant rs1065386 [ dbSNP | Ensembl ].
VAR_059497
Natural varianti97 – 971T → A.
Corresponds to variant rs1050393 [ dbSNP | Ensembl ].
VAR_056443
Natural varianti98 – 981D → Y.
Corresponds to variant rs1131215 [ dbSNP | Ensembl ].
VAR_059498
Natural varianti101 – 1011S → N.
Corresponds to variant rs1050388 [ dbSNP | Ensembl ].
VAR_056444
Natural varianti137 – 1371H → Y.
Corresponds to variant rs1050379 [ dbSNP | Ensembl ].
VAR_056445
Natural varianti155 – 1551R → S.
Corresponds to variant rs1050654 [ dbSNP | Ensembl ].
VAR_056446
Natural varianti187 – 1871E → A.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
VAR_059499
Natural varianti187 – 1871E → G.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
VAR_059500
Natural varianti187 – 1871E → K.
Corresponds to variant rs2523600 [ dbSNP | Ensembl ].
VAR_059501
Natural varianti187 – 1871E → Q.
Corresponds to variant rs2523600 [ dbSNP | Ensembl ].
VAR_059502
Natural varianti187 – 1871E → V.
Corresponds to variant rs2308466 [ dbSNP | Ensembl ].
VAR_059503
Natural varianti195 – 1951Y → H.
Corresponds to variant rs1050696 [ dbSNP | Ensembl ].
VAR_056447
Natural varianti306 – 3061V → I.
Corresponds to variant rs1131500 [ dbSNP | Ensembl ].
VAR_056448
Natural varianti329 – 3291A → T.
Corresponds to variant rs1051488 [ dbSNP | Ensembl ].
VAR_056449
Natural varianti349 – 3491C → S.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061439
Natural varianti349 – 3491C → Y.
Corresponds to variant rs2308655 [ dbSNP | Ensembl ].
VAR_061440

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37880 mRNA. Translation: AAC41941.1.
X90390 mRNA. Translation: CAA62035.1.
U09912 mRNA. Translation: AAF70855.1.
UniGeneiHs.654404.
Hs.77961.

Genome annotation databases

EnsembliENST00000412585; ENSP00000399168; ENSG00000234745.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L37880 mRNA. Translation: AAC41941.1 .
X90390 mRNA. Translation: CAA62035.1 .
U09912 mRNA. Translation: AAF70855.1 .
UniGenei Hs.654404.
Hs.77961.

3D structure databases

ProteinModelPortali Q31610.
SMRi Q31610. Positions 25-299.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q31610.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000412585 ; ENSP00000399168 ; ENSG00000234745 .

Organism-specific databases

GeneCardsi GC06M031321.
HGNCi HGNC:4932. HLA-B.
HPAi CAB015418.
MIMi 142830. gene.
neXtProti NX_Q31610.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG016709.
TreeFami TF336617.

Enzyme and pathway databases

Reactomei REACT_111168. Endosomal/Vacuolar pathway.
REACT_111178. ER-Phagosome pathway.
REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_25078. Interferon gamma signaling.
REACT_25162. Interferon alpha/beta signaling.
REACT_75795. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSi HLA-B. human.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q31610.
Bgeei Q31610.
CleanExi HS_HLA-B.
Genevestigatori Q31610.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence analysis of HLA-B*1523 and B*8101. Dominant alpha-helical motifs produce complex serologic recognition patterns for the HLA-B''DT'' and HLA-B''NM5'' antigens."
    Ellexson M.E., Zhang G., Stewart D., Lau M., Teresi G., Terasaki P., Roe B.A., Hildebrand W.H.
    Hum. Immunol. 44:103-110(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*81:01).
  2. "Molecular characterization of the new alleles HLA-B*8101 and B*4407."
    Vilches C., Sanz L., de Pablo R., Moreno M.E., Puente S., Kreisler M.
    Tissue Antigens 47:139-142(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*81:01).
  3. "HLA-B'DT', a class I allele most homologous with HLA-B-4801."
    Hildebrand W.H., Ellexson M.E.
    Submitted (MAY-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ALLELE B*81:01).
  4. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-65, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry namei1B81_HUMAN
AccessioniPrimary (citable) accession number: Q31610
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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