Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

DMA protein

Gene

DMA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
DMA proteinImported
Submitted name:
HLA-DMA proteinImported
Submitted name:
MHC class II antigenImported
Submitted name:
Major histocompatibility complex, class II, DM alphaImported
Submitted name:
Major histocompatibility complex, class II, DM alpha, isoform CRA_cImported
Submitted name:
cDNA FLJ75740, highly similar to Homo sapiens major histocompatibility complex, class II, DM alpha (HLA-DMA), mRNAImported
Gene namesi
Name:DMAImported
Synonyms:HLA-DMAImported
ORF Names:hCG_2001572Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35058.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500878009027 – 261Sequence analysisAdd BLAST235

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000204257.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363976.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 215Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST95

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IR26. Eukaryota.
ENOG410YJDD. LUCA.
HOVERGENiHBG001688.
KOiK06752.
OMAiEEDAPIF.
OrthoDBiEOG091G0LMN.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q31604-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC
60 70 80 90 100
QDGSPSVGLS EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF
110 120 130 140 150
DKEFCEWMIQ QIGPKLDGKI PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS
160 170 180 190 200
NLFPPMLTVN WQHHSVPVEG FGPTFVSAVD GLSFQAFSYL NFTPEPSDIF
210 220 230 240 250
SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG VLGIIVGIVL
260
IIYFRKPCSG D
Length:261
Mass (Da):29,207
Last modified:November 1, 1996 - v1
Checksum:iBAAB2528874DFFC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011447 mRNA. Translation: AAH11447.1.
BC026279 mRNA. Translation: AAH26279.1.
KJ657694 Genomic DNA. Translation: AHW47929.1.
KJ657695 Genomic DNA. Translation: AHW47946.1.
KJ657696 Genomic DNA. Translation: AHW47963.1.
AK291858 mRNA. Translation: BAF84547.1.
X76775 Genomic DNA. Translation: CAA54169.1.
X87344 Genomic DNA. Translation: CAA60781.1.
CH471081 Genomic DNA. Translation: EAX03660.1.
PIRiI37531.
RefSeqiNP_006111.2. NM_006120.3.
UniGeneiHs.728759.

Genome annotation databases

GeneIDi3108.
KEGGihsa:3108.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011447 mRNA. Translation: AAH11447.1.
BC026279 mRNA. Translation: AAH26279.1.
KJ657694 Genomic DNA. Translation: AHW47929.1.
KJ657695 Genomic DNA. Translation: AHW47946.1.
KJ657696 Genomic DNA. Translation: AHW47963.1.
AK291858 mRNA. Translation: BAF84547.1.
X76775 Genomic DNA. Translation: CAA54169.1.
X87344 Genomic DNA. Translation: CAA60781.1.
CH471081 Genomic DNA. Translation: EAX03660.1.
PIRiI37531.
RefSeqiNP_006111.2. NM_006120.3.
UniGeneiHs.728759.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363976.

Protocols and materials databases

DNASUi3108.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3108.
KEGGihsa:3108.

Organism-specific databases

CTDi3108.
PharmGKBiPA35058.

Phylogenomic databases

eggNOGiENOG410IR26. Eukaryota.
ENOG410YJDD. LUCA.
HOVERGENiHBG001688.
KOiK06752.
OMAiEEDAPIF.
OrthoDBiEOG091G0LMN.

Miscellaneous databases

ChiTaRSiHLA-DMA. human.
GenomeRNAii3108.

Gene expression databases

BgeeiENSG00000204257.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ31604_HUMAN
AccessioniPrimary (citable) accession number: Q31604
Secondary accession number(s): O02966, Q96FA1
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 169 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.