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Q313T7

- HISX_DESAG

UniProt

Q313T7 - HISX_DESAG

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Protein

Histidinol dehydrogenase

Gene
hisD, Dde_1008
Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei242 – 2421Substrate By similarity
Metal bindingi264 – 2641Zinc By similarity
Binding sitei264 – 2641Substrate By similarity
Metal bindingi267 – 2671Zinc By similarity
Binding sitei267 – 2671Substrate By similarity
Active sitei332 – 3321Proton acceptor By similarity
Active sitei333 – 3331Proton acceptor By similarity
Binding sitei333 – 3331Substrate By similarity
Metal bindingi366 – 3661Zinc By similarity
Binding sitei366 – 3661Substrate By similarity
Binding sitei420 – 4201Substrate By similarity
Metal bindingi425 – 4251Zinc By similarity
Binding sitei425 – 4251Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciDALA207559:GH1L-872-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Dde_1008
OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Taxonomic identifieri207559 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002710: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Histidinol dehydrogenaseUniRule annotationPRO_0000229856Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi207559.Dde_1008.

Structurei

3D structure databases

ProteinModelPortaliQ313T7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiCAIANRI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q313T7-1 [UniParc]FASTAAdd to Basket

« Hide

MPCRTLTYSS EADWQGIRDM LCGRENPENS VEPVVREIMD AIRSDGDAAL    50
AGYTRRFDCP DFDPSSLRVA PDAIEKAARE IPRHDLQIIT EAADNIRHFH 100
SAQKEEAWFI TRPDGTVLGQ MTRPVDSAGL YVPGGQGGNT PLISSLLMNA 150
VPAQVAGVPR IAVTTPPRKD GTLNPYILAA AHVLGLDEIY CAGSAWAVAA 200
LAYGTQTIAP VDFIAGPGNI FVTTAKRMLI GTVGIDMIAG PSEILIIADS 250
QADAAHVAAD MLSQAEHDPL ASAILVTPSP QLAAAVHTEL EKQVTGLDRA 300
DIARASLRDW SAIVVTPDLN SAVELSNKVA PEHLELLVQD TWGLLGSIRN 350
AGAIFMGPHS PEPVGDYFAG PNHVLPTMGT ARFSSALSVQ SFCKKSSIIA 400
ASQTFTQTNA AKIARLARLE GLEAHARSVE SRLS 434
Length:434
Mass (Da):46,150
Last modified:December 6, 2005 - v1
Checksum:i138E0CF1201CA85C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000112 Genomic DNA. Translation: ABB37809.1.
RefSeqiYP_387504.1. NC_007519.1.

Genome annotation databases

EnsemblBacteriaiABB37809; ABB37809; Dde_1008.
GeneIDi3755510.
KEGGidde:Dde_1008.
PATRICi21740953. VBIDesDes50040_1010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000112 Genomic DNA. Translation: ABB37809.1 .
RefSeqi YP_387504.1. NC_007519.1.

3D structure databases

ProteinModelPortali Q313T7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 207559.Dde_1008.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB37809 ; ABB37809 ; Dde_1008 .
GeneIDi 3755510.
KEGGi dde:Dde_1008.
PATRICi 21740953. VBIDesDes50040_1010.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi CAIANRI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci DALA207559:GH1L-872-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G20.

Entry informationi

Entry nameiHISX_DESAG
AccessioniPrimary (citable) accession number: Q313T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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