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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:Dde_1039
OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Taxonomic identifieri207559 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002710 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei21 – 41HelicalUniRule annotationAdd BLAST21
Transmembranei69 – 89HelicalUniRule annotationAdd BLAST21
Transmembranei92 – 112HelicalUniRule annotationAdd BLAST21
Transmembranei133 – 153HelicalUniRule annotationAdd BLAST21
Transmembranei169 – 189HelicalUniRule annotationAdd BLAST21
Transmembranei196 – 216HelicalUniRule annotationAdd BLAST21
Transmembranei233 – 253HelicalUniRule annotationAdd BLAST21
Transmembranei260 – 280HelicalUniRule annotationAdd BLAST21
Transmembranei285 – 305HelicalUniRule annotationAdd BLAST21
Transmembranei335 – 355HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002354511 – 358Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST358

Interactioni

Protein-protein interaction databases

STRINGi207559.Dde_1039.

Structurei

3D structure databases

SMRiQ313Q6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q313Q6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYHFLYPLS AELPLLNVFR YITFRSVWAL LTALLITIFI GPRFIRWLKR
60 70 80 90 100
VKCGQYIQEE VSCHVQKAGT PTMGGLLIGF SLIISVLLWG DLTNVYLWLV
110 120 130 140 150
MLVFTGFGLV GFLDDYTKLR RKTNQGLTAR SKFLWQMVIA AVAMYFLVKE
160 170 180 190 200
PAYSTVLSFP FFKNLQPDLG WFYIPFAMIV LVGSSNGVNL TDGMDGLAIG
210 220 230 240 250
PTVVAGIVFS IFIYIAGHSQ IAGYLQVPYV PGMGEVTVFC GALIGAGLGF
260 270 280 290 300
LWFNAYPAQV FMGDVGSLSL GGALGFLAVL CKQELIMLVA GGLFVLESLS
310 320 330 340 350
VILQVGYFRM TGGKRIFRMA PLHHHFELKG IPESKIIIRF WIMSIVFGLM

ALSVLKLR
Length:358
Mass (Da):39,776
Last modified:December 6, 2005 - v1
Checksum:i9D3D73CB99A9B53C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000112 Genomic DNA. Translation: ABB37840.1.
RefSeqiWP_011367077.1. NC_007519.1.

Genome annotation databases

EnsemblBacteriaiABB37840; ABB37840; Dde_1039.
KEGGidde:Dde_1039.

Similar proteinsi

Entry informationi

Entry nameiMRAY_DESAG
AccessioniPrimary (citable) accession number: Q313Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 6, 2005
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families