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Q313H2

- DXR_DESAG

UniProt

Q313H2 - DXR_DESAG

Protein

1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene

dxr

Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).UniRule annotation

    Catalytic activityi

    2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotation

    Cofactori

    Divalent cation.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei141 – 1411SubstrateUniRule annotation
    Metal bindingi166 – 1661Divalent metal cationUniRule annotation
    Metal bindingi168 – 1681Divalent metal cationUniRule annotation
    Binding sitei168 – 1681SubstrateUniRule annotation
    Binding sitei192 – 1921SubstrateUniRule annotation
    Binding sitei215 – 2151SubstrateUniRule annotation
    Metal bindingi237 – 2371Divalent metal cationUniRule annotation
    Binding sitei237 – 2371SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 5330NADPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW
    3. NADPH binding Source: InterPro

    GO - Biological processi

    1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Isoprene biosynthesis

    Keywords - Ligandi

    Metal-binding, NADP

    Enzyme and pathway databases

    BioCyciDALA207559:GH1L-975-MONOMER.
    UniPathwayiUPA00056; UER00092.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-deoxy-D-xylulose 5-phosphate reductoisomeraseUniRule annotation (EC:1.1.1.267UniRule annotation)
    Short name:
    DXP reductoisomeraseUniRule annotation
    Alternative name(s):
    1-deoxyxylulose-5-phosphate reductoisomeraseUniRule annotation
    2-C-methyl-D-erythritol 4-phosphate synthaseUniRule annotation
    Gene namesi
    Name:dxrUniRule annotation
    Ordered Locus Names:Dde_1123
    OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
    Taxonomic identifieri207559 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000002710: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4074071-deoxy-D-xylulose 5-phosphate reductoisomerasePRO_1000020255Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi207559.Dde_1123.

    Structurei

    3D structure databases

    ProteinModelPortaliQ313H2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DXR family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0743.
    HOGENOMiHOG000007221.
    KOiK00099.
    OMAiTAGRLIM.
    OrthoDBiEOG6R2H04.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00183. DXP_reductoisom.
    InterProiIPR003821. DXP_reductoisomerase.
    IPR013644. DXP_reductoisomerase_C.
    IPR013512. DXP_reductoisomerase_N.
    IPR026877. DXPR_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR30525. PTHR30525. 1 hit.
    PfamiPF08436. DXP_redisom_C. 1 hit.
    PF02670. DXP_reductoisom. 1 hit.
    PF13288. DXPR_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006205. Dxp_reductismrs. 1 hit.
    SUPFAMiSSF69055. SSF69055. 1 hit.
    TIGRFAMsiTIGR00243. Dxr. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q313H2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGYISPLPD AAWNSRFPRS LVLLGSTGSI GTSALRVVER QPELFRITAL    50
    AGARNVRLLA RQAAAYRPPH LAVINGNAAD ELASLLPAGY RPRIHTGQEG 100
    YEFLAALPEA DCVLSAQVGA AGLRATVAAA RAGKTIALAN KESLVLAGGL 150
    IRRLCHETGA SVLPVDSEHN AIFQALQGHD AAQMRRIILT ASGGPFRGRD 200
    RTFLQSVTRE QALNHPNWSM GAKISIDSAT LMNKGLEVIE ACHLYNAPLE 250
    KVEVVVHPQS IIHSLVEYND GSQIAHMGTP DMRIAIAYCL GWPRVMHTGV 300
    EPLDLLSVGS LTFESPDISL FPCLELARKA YAGGNGLPVV LNAANEVAVD 350
    LFLQGAIAFL DIPRLIEAAM QAHDAAPHQN MYDEVESILT LDKTTRRVTA 400
    DLAGARG 407
    Length:407
    Mass (Da):43,573
    Last modified:December 6, 2005 - v1
    Checksum:i7C196C23DA5135E3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000112 Genomic DNA. Translation: ABB37924.1.
    RefSeqiYP_387619.1. NC_007519.1.

    Genome annotation databases

    EnsemblBacteriaiABB37924; ABB37924; Dde_1123.
    GeneIDi3755147.
    KEGGidde:Dde_1123.
    PATRICi21741195. VBIDesDes50040_1130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000112 Genomic DNA. Translation: ABB37924.1 .
    RefSeqi YP_387619.1. NC_007519.1.

    3D structure databases

    ProteinModelPortali Q313H2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 207559.Dde_1123.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB37924 ; ABB37924 ; Dde_1123 .
    GeneIDi 3755147.
    KEGGi dde:Dde_1123.
    PATRICi 21741195. VBIDesDes50040_1130.

    Phylogenomic databases

    eggNOGi COG0743.
    HOGENOMi HOG000007221.
    KOi K00099.
    OMAi TAGRLIM.
    OrthoDBi EOG6R2H04.

    Enzyme and pathway databases

    UniPathwayi UPA00056 ; UER00092 .
    BioCyci DALA207559:GH1L-975-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00183. DXP_reductoisom.
    InterProi IPR003821. DXP_reductoisomerase.
    IPR013644. DXP_reductoisomerase_C.
    IPR013512. DXP_reductoisomerase_N.
    IPR026877. DXPR_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR30525. PTHR30525. 1 hit.
    Pfami PF08436. DXP_redisom_C. 1 hit.
    PF02670. DXP_reductoisom. 1 hit.
    PF13288. DXPR_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006205. Dxp_reductismrs. 1 hit.
    SUPFAMi SSF69055. SSF69055. 1 hit.
    TIGRFAMsi TIGR00243. Dxr. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G20.

    Entry informationi

    Entry nameiDXR_DESAG
    AccessioniPrimary (citable) accession number: Q313H2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3