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Q313H2 (DXR_DESAG) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase

Short name=DXP reductoisomerase
EC=1.1.1.267
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase
2-C-methyl-D-erythritol 4-phosphate synthase
Gene names
Name:dxr
Ordered Locus Names:Dde_1123
OrganismDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20)) [Complete proteome] [HAMAP]
Taxonomic identifier207559 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length407 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP-Rule MF_00183

Catalytic activity

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH. HAMAP-Rule MF_00183

Cofactor

Divalent cation By similarity. HAMAP-Rule MF_00183

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6. HAMAP-Rule MF_00183

Sequence similarities

Belongs to the DXR family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4074071-deoxy-D-xylulose 5-phosphate reductoisomerase HAMAP-Rule MF_00183
PRO_1000020255

Regions

Nucleotide binding24 – 5330NADP By similarity

Sites

Metal binding1661Divalent metal cation By similarity
Metal binding1681Divalent metal cation By similarity
Metal binding2371Divalent metal cation By similarity
Binding site1411Substrate By similarity
Binding site1681Substrate By similarity
Binding site1921Substrate By similarity
Binding site2151Substrate By similarity
Binding site2371Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q313H2 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 7C196C23DA5135E3

FASTA40743,573
        10         20         30         40         50         60 
MNGYISPLPD AAWNSRFPRS LVLLGSTGSI GTSALRVVER QPELFRITAL AGARNVRLLA 

        70         80         90        100        110        120 
RQAAAYRPPH LAVINGNAAD ELASLLPAGY RPRIHTGQEG YEFLAALPEA DCVLSAQVGA 

       130        140        150        160        170        180 
AGLRATVAAA RAGKTIALAN KESLVLAGGL IRRLCHETGA SVLPVDSEHN AIFQALQGHD 

       190        200        210        220        230        240 
AAQMRRIILT ASGGPFRGRD RTFLQSVTRE QALNHPNWSM GAKISIDSAT LMNKGLEVIE 

       250        260        270        280        290        300 
ACHLYNAPLE KVEVVVHPQS IIHSLVEYND GSQIAHMGTP DMRIAIAYCL GWPRVMHTGV 

       310        320        330        340        350        360 
EPLDLLSVGS LTFESPDISL FPCLELARKA YAGGNGLPVV LNAANEVAVD LFLQGAIAFL 

       370        380        390        400 
DIPRLIEAAM QAHDAAPHQN MYDEVESILT LDKTTRRVTA DLAGARG 

« Hide

References

[1]"Complete genome sequence and updated annotation of Desulfovibrio alaskensis G20."
Hauser L.J., Land M.L., Brown S.D., Larimer F., Keller K.L., Rapp-Giles B.J., Price M.N., Lin M., Bruce D.C., Detter J.C., Tapia R., Han C.S., Goodwin L.A., Cheng J.F., Pitluck S., Copeland A., Lucas S., Nolan M. expand/collapse author list , Lapidus A.L., Palumbo A.V., Wall J.D.
J. Bacteriol. 193:4268-4269(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: G20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000112 Genomic DNA. Translation: ABB37924.1.
RefSeqYP_387619.1. NC_007519.1.

3D structure databases

ProteinModelPortalQ313H2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING207559.Dde_1123.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB37924; ABB37924; Dde_1123.
GeneID3755147.
KEGGdde:Dde_1123.
PATRIC21741195. VBIDesDes50040_1130.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0743.
HOGENOMHOG000007221.
KOK00099.
OMATAGRLIM.
OrthoDBEOG6R2H04.

Enzyme and pathway databases

BioCycDALA207559:GH1L-975-MONOMER.
UniPathwayUPA00056; UER00092.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00183. DXP_reductoisom.
InterProIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR30525. PTHR30525. 1 hit.
PfamPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view]
PIRSFPIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMSSF69055. SSF69055. 1 hit.
TIGRFAMsTIGR00243. Dxr. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDXR_DESAG
AccessionPrimary (citable) accession number: Q313H2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways