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Q313H2

- DXR_DESAG

UniProt

Q313H2 - DXR_DESAG

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Protein
1-deoxy-D-xylulose 5-phosphate reductoisomerase
Gene
dxr, Dde_1123
Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity.UniRule annotation

Catalytic activityi

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotation

Cofactori

Divalent cation By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei141 – 1411Substrate By similarity
Metal bindingi166 – 1661Divalent metal cation By similarity
Metal bindingi168 – 1681Divalent metal cation By similarity
Binding sitei168 – 1681Substrate By similarity
Binding sitei192 – 1921Substrate By similarity
Binding sitei215 – 2151Substrate By similarity
Metal bindingi237 – 2371Divalent metal cation By similarity
Binding sitei237 – 2371Substrate By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 5330NADP By similarity
Add
BLAST

GO - Molecular functioni

  1. 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity Source: UniProtKB-HAMAP
  2. NADPH binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway Source: UniProtKB-UniPathway
  2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Isoprene biosynthesis

Keywords - Ligandi

Metal-binding, NADP

Enzyme and pathway databases

BioCyciDALA207559:GH1L-975-MONOMER.
UniPathwayiUPA00056; UER00092.

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomerase (EC:1.1.1.267)
Short name:
DXP reductoisomerase
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomerase
2-C-methyl-D-erythritol 4-phosphate synthase
Gene namesi
Name:dxr
Ordered Locus Names:Dde_1123
OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Taxonomic identifieri207559 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002710: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4074071-deoxy-D-xylulose 5-phosphate reductoisomeraseUniRule annotation
PRO_1000020255Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi207559.Dde_1123.

Structurei

3D structure databases

ProteinModelPortaliQ313H2.

Family & Domainsi

Sequence similaritiesi

Belongs to the DXR family.

Phylogenomic databases

eggNOGiCOG0743.
HOGENOMiHOG000007221.
KOiK00099.
OMAiTAGRLIM.
OrthoDBiEOG6R2H04.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00183. DXP_reductoisom.
InterProiIPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR30525. PTHR30525. 1 hit.
PfamiPF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMiSSF69055. SSF69055. 1 hit.
TIGRFAMsiTIGR00243. Dxr. 1 hit.

Sequencei

Sequence statusi: Complete.

Q313H2-1 [UniParc]FASTAAdd to Basket

« Hide

MNGYISPLPD AAWNSRFPRS LVLLGSTGSI GTSALRVVER QPELFRITAL    50
AGARNVRLLA RQAAAYRPPH LAVINGNAAD ELASLLPAGY RPRIHTGQEG 100
YEFLAALPEA DCVLSAQVGA AGLRATVAAA RAGKTIALAN KESLVLAGGL 150
IRRLCHETGA SVLPVDSEHN AIFQALQGHD AAQMRRIILT ASGGPFRGRD 200
RTFLQSVTRE QALNHPNWSM GAKISIDSAT LMNKGLEVIE ACHLYNAPLE 250
KVEVVVHPQS IIHSLVEYND GSQIAHMGTP DMRIAIAYCL GWPRVMHTGV 300
EPLDLLSVGS LTFESPDISL FPCLELARKA YAGGNGLPVV LNAANEVAVD 350
LFLQGAIAFL DIPRLIEAAM QAHDAAPHQN MYDEVESILT LDKTTRRVTA 400
DLAGARG 407
Length:407
Mass (Da):43,573
Last modified:December 6, 2005 - v1
Checksum:i7C196C23DA5135E3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000112 Genomic DNA. Translation: ABB37924.1.
RefSeqiYP_387619.1. NC_007519.1.

Genome annotation databases

EnsemblBacteriaiABB37924; ABB37924; Dde_1123.
GeneIDi3755147.
KEGGidde:Dde_1123.
PATRICi21741195. VBIDesDes50040_1130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000112 Genomic DNA. Translation: ABB37924.1 .
RefSeqi YP_387619.1. NC_007519.1.

3D structure databases

ProteinModelPortali Q313H2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 207559.Dde_1123.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB37924 ; ABB37924 ; Dde_1123 .
GeneIDi 3755147.
KEGGi dde:Dde_1123.
PATRICi 21741195. VBIDesDes50040_1130.

Phylogenomic databases

eggNOGi COG0743.
HOGENOMi HOG000007221.
KOi K00099.
OMAi TAGRLIM.
OrthoDBi EOG6R2H04.

Enzyme and pathway databases

UniPathwayi UPA00056 ; UER00092 .
BioCyci DALA207559:GH1L-975-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00183. DXP_reductoisom.
InterProi IPR003821. DXP_reductoisomerase.
IPR013644. DXP_reductoisomerase_C.
IPR013512. DXP_reductoisomerase_N.
IPR026877. DXPR_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR30525. PTHR30525. 1 hit.
Pfami PF08436. DXP_redisom_C. 1 hit.
PF02670. DXP_reductoisom. 1 hit.
PF13288. DXPR_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF006205. Dxp_reductismrs. 1 hit.
SUPFAMi SSF69055. SSF69055. 1 hit.
TIGRFAMsi TIGR00243. Dxr. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G20.

Entry informationi

Entry nameiDXR_DESAG
AccessioniPrimary (citable) accession number: Q313H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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