Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q311A7 (GCSPA_DESAG) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:Dde_1692
OrganismDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20)) [Complete proteome] [HAMAP]
Taxonomic identifier207559 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_1000045643

Sequences

Sequence LengthMass (Da)Tools
Q311A7 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 9896B212D8282431

FASTA44348,396
        10         20         30         40         50         60 
MPYTPHTPEE IRQMLDVIGV KSIDDLFAEI PPEMQPRSFD IPEGMSEMEV CARIQRMAAK 

        70         80         90        100        110        120 
NRIDLVSYLG AGFYDHHIPK AVDNLVSRGE FYTAYTPYQP EASQGTLQAI FEYQTAVCRL 

       130        140        150        160        170        180 
MEMEVANASV YDGGSAIFEA MMMAARATRR SKLVIDEALS PIYRTMLASY TSNLNMELVT 

       190        200        210        220        230        240 
VAHNEGRSDK QALMDAVDDK CAAVVVQNPN FFGAVDDFTE LFTHARSCNA LGVISVYPVM 

       250        260        270        280        290        300 
QSVLKTPGEM GADIAVADGQ SLGMPLSFGG PYLGIMTCTK KLARQIPGRI AGRTKDVDGK 

       310        320        330        340        350        360 
TGYVLTLQAR EQHIRRAKAT SNICSNQALC ALRAIIHMCL TGPEGLVRTA ELSMERAHYA 

       370        380        390        400        410        420 
ADRLTALPGV SLLHDAPFCN EFALRLPVSA YDVVDRLVNH GVVPGFPLGG YYAGMDDVLL 

       430        440 
VACTEKHSFE QIGIMAELVG GML 

« Hide

References

[1]"Complete genome sequence and updated annotation of Desulfovibrio alaskensis G20."
Hauser L.J., Land M.L., Brown S.D., Larimer F., Keller K.L., Rapp-Giles B.J., Price M.N., Lin M., Bruce D.C., Detter J.C., Tapia R., Han C.S., Goodwin L.A., Cheng J.F., Pitluck S., Copeland A., Lucas S., Nolan M. expand/collapse author list , Lapidus A.L., Palumbo A.V., Wall J.D.
J. Bacteriol. 193:4268-4269(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: G20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000112 Genomic DNA. Translation: ABB38489.1.
RefSeqYP_388184.1. NC_007519.1.

3D structure databases

ProteinModelPortalQ311A7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING207559.Dde_1692.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB38489; ABB38489; Dde_1692.
GeneID3756690.
KEGGdde:Dde_1692.
PATRIC21742337. VBIDesDes50040_1687.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
HOGENOMHOG000132025.
KOK00282.
OMALPMHASE.
OrthoDBEOG6XWV3B.

Enzyme and pathway databases

BioCycDALA207559:GH1L-1486-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_DESAG
AccessionPrimary (citable) accession number: Q311A7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families