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Q311A7

- GCSPA_DESAG

UniProt

Q311A7 - GCSPA_DESAG

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, Dde_1692
Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciDALA207559:GH1L-1486-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Dde_1692
OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Taxonomic identifieri207559 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002710: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_1000045643Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi207559.Dde_1692.

Structurei

3D structure databases

ProteinModelPortaliQ311A7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiLPMHASE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q311A7-1 [UniParc]FASTAAdd to Basket

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MPYTPHTPEE IRQMLDVIGV KSIDDLFAEI PPEMQPRSFD IPEGMSEMEV    50
CARIQRMAAK NRIDLVSYLG AGFYDHHIPK AVDNLVSRGE FYTAYTPYQP 100
EASQGTLQAI FEYQTAVCRL MEMEVANASV YDGGSAIFEA MMMAARATRR 150
SKLVIDEALS PIYRTMLASY TSNLNMELVT VAHNEGRSDK QALMDAVDDK 200
CAAVVVQNPN FFGAVDDFTE LFTHARSCNA LGVISVYPVM QSVLKTPGEM 250
GADIAVADGQ SLGMPLSFGG PYLGIMTCTK KLARQIPGRI AGRTKDVDGK 300
TGYVLTLQAR EQHIRRAKAT SNICSNQALC ALRAIIHMCL TGPEGLVRTA 350
ELSMERAHYA ADRLTALPGV SLLHDAPFCN EFALRLPVSA YDVVDRLVNH 400
GVVPGFPLGG YYAGMDDVLL VACTEKHSFE QIGIMAELVG GML 443
Length:443
Mass (Da):48,396
Last modified:December 6, 2005 - v1
Checksum:i9896B212D8282431
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000112 Genomic DNA. Translation: ABB38489.1.
RefSeqiYP_388184.1. NC_007519.1.

Genome annotation databases

EnsemblBacteriaiABB38489; ABB38489; Dde_1692.
GeneIDi3756690.
KEGGidde:Dde_1692.
PATRICi21742337. VBIDesDes50040_1687.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000112 Genomic DNA. Translation: ABB38489.1 .
RefSeqi YP_388184.1. NC_007519.1.

3D structure databases

ProteinModelPortali Q311A7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 207559.Dde_1692.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB38489 ; ABB38489 ; Dde_1692 .
GeneIDi 3756690.
KEGGi dde:Dde_1692.
PATRICi 21742337. VBIDesDes50040_1687.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi LPMHASE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci DALA207559:GH1L-1486-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G20.

Entry informationi

Entry nameiGCSPA_DESAG
AccessioniPrimary (citable) accession number: Q311A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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