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Protein
Submitted name:

MHC class II antigen IEk-beta

Gene

H2-Eb1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II antigen IEk-betaImported
Gene namesi
Name:H2-Eb1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95901 H2-Eb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei225 – 247HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501430902926 – 263Sequence analysisAdd BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 105Combined sources
Glycosylationi45N-linked (GlcNAc...)Combined sources1
Disulfide bondi143 ↔ 199Combined sources

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IEAX-ray2.30B/D29-224[»]
4P2OX-ray2.60B29-224[»]
4P2QX-ray3.30B/G/L/Q29-224[»]
4P2RX-ray3.29B/G/L/Q29-224[»]
ProteinModelPortaliQ31163
SMRiQ31163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 213Ig-likeInterPro annotationAdd BLAST91

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IWG3 Eukaryota
ENOG410YI0S LUCA
HOVERGENiHBG012730

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q31163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLPRVPCVA AVILLLTVLS PPVALVRDSR PWFLEYCKSE CHFYNGTQRV
60 70 80 90 100
RLLVRYFYNL EENLRFDSDV GEFRAVTELG RPDAENWNSQ PEFLEQKRAE
110 120 130 140 150
VDTVCRHNYE IFDNFLVPRR VEPTVTVYPT KTQPLEHHNL LVCSVSDFYP
160 170 180 190 200
GNIEVRWFRN GKEEKTGIVS TGLVRNGDWT FQTLVMLETV PQSGEVYTCQ
210 220 230 240 250
VEHPSLTDPV TVEWKAQSTS AQNKMLSGVG GFVLGLLFLG AGLFIYFRNQ
260
KGQSGLQPTG LLS
Length:263
Mass (Da):30,011
Last modified:November 1, 1996 - v1
Checksum:iF5E40F56130A4E45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36939 mRNA Translation: AAA39593.1
KX981919 mRNA Translation: ATD50493.1
PIRiA46561
UniGeneiMm.22564

Similar proteinsi

Entry informationi

Entry nameiQ31163_MOUSE
AccessioniPrimary (citable) accession number: Q31163
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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