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Q31135 (Q31135_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

MHC class II H2-IA-beta chain (haplotype NOD) EMBL AAA39547.1
Gene names
Name:H2-Ab1 MGI 103070
OrganismMus musculus (Mouse) EMBL AAA39547.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS014745

Ontologies

Keywords
   Biological processImmunity
   Cellular componentMembrane
MHC II SAAS SAAS014745 RuleBase RU000321
   DomainSignal EMBL AAA39547.1
Transmembrane
Transmembrane helix SAAS SAAS014745
   PTMDisulfide bond SAAS SAAS014745
   Technical term3D-structure PDB 1F3J PDB 3MBE PDB 3CUP
Gene Ontology (GO)
   Biological_processantigen processing and presentation

Inferred from direct assay PubMed 9432982. Source: MGI

antigen processing and presentation of exogenous peptide antigen via MHC class II

Inferred from direct assay PubMed 11027433PubMed 11069069PubMed 11714799PubMed 7679955PubMed 8598040PubMed 8598041PubMed 9432982PubMed 9492004. Source: MGI

antigen processing and presentation of peptide antigen

Inferred from direct assay PubMed 11069069. Source: MGI

immune response

Inferred from mutant phenotype PubMed 1909605. Source: MGI

   Cellular_componentGolgi apparatus

Inferred from direct assay PubMed 7679955. Source: MGI

MHC class II protein complex

Inferred from direct assay PubMed 11148202PubMed 7679955PubMed 7985028PubMed 8598040PubMed 8598041PubMed 8638109PubMed 9432982PubMed 9492004. Source: MGI

early endosome

Inferred from direct assay PubMed 11854359. Source: MGI

external side of plasma membrane

Inferred from direct assay PubMed 11148202PubMed 12801066PubMed 14643301PubMed 7679955PubMed 8598040PubMed 8598041PubMed 8638109PubMed 9432982PubMed 9492004. Source: MGI

integral component of membrane

Inferred from direct assay PubMed 7584146. Source: MGI

intracellular

Inferred from direct assay PubMed 8890155. Source: MGI

multivesicular body

Inferred from direct assay PubMed 11854359. Source: MGI

plasma membrane

Inferred from direct assay PubMed 11854359PubMed 7679955PubMed 7985028PubMed 8638109PubMed 8890155. Source: MGI

   Molecular_functionpeptide antigen binding

Inferred from direct assay PubMed 11069069PubMed 9432982. Source: MGI

protein binding

Inferred from physical interaction PubMed 7985028. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential EMBL AAA39547.1
Chain28 – 263236 Potential EMBL AAA39547.1
PRO_5000143060

Amino acid modifications

Glycosylation461N-linked (GlcNAc...) PDB 1F3J

Sequences

Sequence LengthMass (Da)Tools
Q31135 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: BF790988F79547E5

FASTA26329,828
        10         20         30         40         50         60 
MALQIPSLLL SAAVVVLMVL SSPGTEGGDS ERHFVHQFKG ECYFTNGTQR IRLVTRYIYN 

        70         80         90        100        110        120 
REEYLRFDSD VGEYRAVTEL GRHSAEYYNK QYLERTRAEL DTACRHNYEE TEVPTSLRRL 

       130        140        150        160        170        180 
EQPNVAISLS RTEALNHHNT LVCSVTDFYP AKIKVRWFRN GQEETVGVSS TQLIRNGDWT 

       190        200        210        220        230        240 
FQVLVMLEMT PHQGEVYTCH VEHPSLKSPI TVEWRAQSES ARSKMLSGIG GCVLGVIFLG 

       250        260 
LGLFIRHRSQ KGPRGPPPAG LLQ 

« Hide

References

« Hide 'large scale' references
[1]"The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique."
Acha-Orbea H., McDevitt H.O.
Proc. Natl. Acad. Sci. U.S.A. 84:2435-2439(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Structural mutation affecting intracellular transport and cell surface expression of murine class II molecules."
Griffith I.J., Nabavi N., Ghogawala Z., Chase C.G., Rodriguez M., McKean D.J., Glimcher L.H.
J. Exp. Med. 167:541-555(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE33331.1.
Tissue: Activated spleen EMBL BAE33890.1.
[4]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE33331.1.
Tissue: Activated spleen EMBL BAE33890.1.
[5]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE33331.1.
Tissue: Activated spleen EMBL BAE33890.1.
[6]"Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice."
Latek R.R., Suri A., Petzold S.J., Nelson C.A., Kanagawa O., Unanue E.R., Fremont D.H.
Immunity 12:699-710(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 31-217, GLYCOSYLATION AT ASN-46.
[7]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE33331.1.
Tissue: Activated spleen EMBL BAE33890.1.
[8]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE33331.1.
Tissue: Activated spleen EMBL BAE33890.1.
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NMRI EMBL AAH08168.1.
Tissue: Mammary tumor. WAP-Tag model. 5 months old EMBL AAH08168.1.
[10]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE33331.1.
Tissue: Activated spleen EMBL BAE33890.1.
[11]Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., Nishiyori H. expand/collapse author list , Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., Muramatsu M., Hayashizaki Y.
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE42176.1.
[12]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE33331.1.
Tissue: Activated spleen EMBL BAE33890.1.
[13]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: NOD EMBL BAE33331.1.
Tissue: Activated spleen EMBL BAE33890.1.
[14]"Crystal structure of the MHC class II molecule I-Ag7 in complex with the peptide GAD221-235."
Yoshida K., Corper A.L., Puckett C., Sim J., Valerie M-D., Jabri B., Wilson I.A., Teyton L.
Submitted (APR-2008) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (3.09 ANGSTROMS) OF 28-214.
[15]"The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity."
Yoshida K., Corper A.L., Herro R., Jabri B., Wilson I.A., Teyton L.
J. Clin. Invest. 120:1578-1590(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) OF 28-214.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M15848 mRNA. Translation: AAA39547.1.
BC008168 mRNA. Translation: AAH08168.1.
AK155573 mRNA. Translation: BAE33331.1.
AK156899 mRNA. Translation: BAE33890.1.
AK171005 mRNA. Translation: BAE42176.1.
AK171211 mRNA. Translation: BAE42316.1.
AK171281 mRNA. Translation: BAE42364.1.
PIRA25911.
A27595.
UniGeneMm.254067.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1F3JX-ray3.10B/E31-217[»]
3CUPX-ray3.09B28-214[»]
3MBEX-ray2.89B/F28-214[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:103070. H2-Ab1.

Phylogenomic databases

HOVERGENHBG012730.
InParanoidQ31135.

Gene expression databases

GenevestigatorQ31135.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ31135.
SOURCESearch...

Entry information

Entry nameQ31135_MOUSE
AccessionPrimary (citable) accession number: Q31135
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)