Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q31135

- Q31135_MOUSE

UniProt

Q31135 - Q31135_MOUSE

Protein
Submitted name:

H2-Ab1 protein

Gene

H2-Ab1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. peptide antigen binding Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. antigen processing and presentation Source: MGI
    2. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: MGI
    3. antigen processing and presentation of peptide antigen Source: MGI
    4. immune response Source: MGI

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    H2-Ab1 proteinImported
    Submitted name:
    MHC class II H2-IA-beta chain (haplotype NOD)Imported
    Gene namesi
    Name:H2-Ab1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:103070. H2-Ab1.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome Source: MGI
    2. external side of plasma membrane Source: MGI
    3. Golgi apparatus Source: MGI
    4. integral component of membrane Source: MGI
    5. intracellular Source: MGI
    6. MHC class II protein complex Source: MGI
    7. multivesicular body Source: MGI
    8. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane, MHC IIUniRule annotationSAAS annotation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727 PotentialImportedAdd
    BLAST
    Chaini28 – 263236 PotentialImportedPRO_5000143060Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi46 – 461N-linked (GlcNAc...)Imported

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ31135.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1F3JX-ray3.10B/E31-217[»]
    3CUPX-ray3.09B28-214[»]
    3MBEX-ray2.89B/F28-214[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ31135.

    Family & Domainsi

    Sequence similaritiesi

    Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

    Keywords - Domaini

    SignalImported, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG012730.
    InParanoidiQ31135.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view]
    ProDomiPD000328. MHC_II_b_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q31135-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALQIPSLLL SAAVVVLMVL SSPGTEGGDS ERHFVHQFKG ECYFTNGTQR    50
    IRLVTRYIYN REEYLRFDSD VGEYRAVTEL GRHSAEYYNK QYLERTRAEL 100
    DTACRHNYEE TEVPTSLRRL EQPNVAISLS RTEALNHHNT LVCSVTDFYP 150
    AKIKVRWFRN GQEETVGVSS TQLIRNGDWT FQVLVMLEMT PHQGEVYTCH 200
    VEHPSLKSPI TVEWRAQSES ARSKMLSGIG GCVLGVIFLG LGLFIRHRSQ 250
    KGPRGPPPAG LLQ 263
    Length:263
    Mass (Da):29,828
    Last modified:November 1, 1996 - v1
    Checksum:iBF790988F79547E5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15848 mRNA. Translation: AAA39547.1.
    BC008168 mRNA. Translation: AAH08168.1.
    AK155573 mRNA. Translation: BAE33331.1.
    AK156899 mRNA. Translation: BAE33890.1.
    AK171005 mRNA. Translation: BAE42176.1.
    AK171211 mRNA. Translation: BAE42316.1.
    AK171281 mRNA. Translation: BAE42364.1.
    PIRiA25911.
    A27595.
    UniGeneiMm.254067.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15848 mRNA. Translation: AAA39547.1 .
    BC008168 mRNA. Translation: AAH08168.1 .
    AK155573 mRNA. Translation: BAE33331.1 .
    AK156899 mRNA. Translation: BAE33890.1 .
    AK171005 mRNA. Translation: BAE42176.1 .
    AK171211 mRNA. Translation: BAE42316.1 .
    AK171281 mRNA. Translation: BAE42364.1 .
    PIRi A25911.
    A27595.
    UniGenei Mm.254067.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1F3J X-ray 3.10 B/E 31-217 [» ]
    3CUP X-ray 3.09 B 28-214 [» ]
    3MBE X-ray 2.89 B/F 28-214 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:103070. H2-Ab1.

    Phylogenomic databases

    HOVERGENi HBG012730.
    InParanoidi Q31135.

    Miscellaneous databases

    EvolutionaryTracei Q31135.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q31135.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view ]
    ProDomi PD000328. MHC_II_b_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique."
      Acha-Orbea H., McDevitt H.O.
      Proc. Natl. Acad. Sci. U.S.A. 84:2435-2439(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Structural mutation affecting intracellular transport and cell surface expression of murine class II molecules."
      Griffith I.J., Nabavi N., Ghogawala Z., Chase C.G., Rodriguez M., McKean D.J., Glimcher L.H.
      J. Exp. Med. 167:541-555(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    4. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    6. "Structural basis of peptide binding and presentation by the type I diabetes-associated MHC class II molecule of NOD mice."
      Latek R.R., Suri A., Petzold S.J., Nelson C.A., Kanagawa O., Unanue E.R., Fremont D.H.
      Immunity 12:699-710(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 31-217, GLYCOSYLATION AT ASN-46.
    7. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    8. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NMRIImported.
      Tissue: Mammary tumor. WAP-Tag model. 5 months oldImported.
    10. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    11. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
    12. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    13. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: NODImported.
      Tissue: Activated spleenImported.
    14. "Crystal structure of the MHC class II molecule I-Ag7 in complex with the peptide GAD221-235."
      Yoshida K., Corper A.L., Puckett C., Sim J., Valerie M-D., Jabri B., Wilson I.A., Teyton L.
      Submitted (APR-2008) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (3.09 ANGSTROMS) OF 28-214.
    15. "The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity."
      Yoshida K., Corper A.L., Herro R., Jabri B., Wilson I.A., Teyton L.
      J. Clin. Invest. 120:1578-1590(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.89 ANGSTROMS) OF 28-214.

    Entry informationi

    Entry nameiQ31135_MOUSE
    AccessioniPrimary (citable) accession number: Q31135
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3