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Q31125

- S39A7_MOUSE

UniProt

Q31125 - S39A7_MOUSE

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Protein

Zinc transporter SLC39A7

Gene

Slc39a7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Zinc transporter, that transports Zn2+ from the endoplasmic reticulum/Golgi apparatus to the cytosol.1 Publication

GO - Molecular functioni

  1. metal ion transmembrane transporter activity Source: InterPro

GO - Biological processi

  1. zinc ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter SLC39A7
Alternative name(s):
Histidine-rich membrane protein Ke4
Solute carrier family 39 member 7
Zrt-, Irt-like protein 7
Short name:
ZIP7
Gene namesi
Name:Slc39a7
Synonyms:H2-Ke4, Hke4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:95909. Slc39a7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721HelicalSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Transmembranei177 – 19721HelicalSequence AnalysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence AnalysisAdd
BLAST
Transmembranei393 – 41321HelicalSequence AnalysisAdd
BLAST
Transmembranei417 – 43721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. Golgi apparatus Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Zinc transporter SLC39A7PRO_0000213689Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei283 – 2831PhosphoserineBy similarity
Cross-linki317 – 317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ31125.
PaxDbiQ31125.
PRIDEiQ31125.

PTM databases

PhosphoSiteiQ31125.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiQ31125.
ExpressionAtlasiQ31125. baseline.
GenevestigatoriQ31125.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Tnfrsf1aP251183EBI-644519,EBI-518014

Protein-protein interaction databases

IntActiQ31125. 2 interactions.
MINTiMINT-1662266.

Structurei

3D structure databases

ProteinModelPortaliQ31125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 136110His-richAdd
BLAST
Compositional biasi252 – 27423His-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0428.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000185308.
HOVERGENiHBG001037.
InParanoidiQ31125.
KOiK14713.
OMAiFYISSVP.
OrthoDBiEOG73NG48.
PhylomeDBiQ31125.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q31125-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMGLRAPHW VAVGLLTWAA LGLLVAGHEG HGDLHKDVEE DFHGHSHGHS
60 70 80 90 100
HEDFHHGHSH GHSHEDFHHG HGHTHESIWH GHAHSHDHGH SREELHHGHS
110 120 130 140 150
HGHSHDSLHH GGHGHAHREH SHGTSREAGA PGIKHHLDTV TLWAYALGAT
160 170 180 190 200
VLISAAPFFV LFLIPVESNS PRHRSLLQIL LSFASGGLLG DAFLHLIPHA
210 220 230 240 250
LEPHSHHAPE QPGHGHSHSG QGPILSVGLW VLSGIVAFLV VEKFVRHVKG
260 270 280 290 300
GHGHSHGHGD RHAHGDSHTH GDRHECSSKE KPSTEEEKEV GGLRKRRGGN
310 320 330 340 350
TGPRDGPVKP QSPEEEKAGS DLRVSGYLNL AADLAHNFTD GLAIGASFRG
360 370 380 390 400
GRGLGILTTM TVLLHEVPHE VGDFAILVQS GCSKKQAMRL QLVTAIGALA
410 420 430 440 450
GTACALLTEG GAVDSDVAGG AGPGWVLPFT AGGFIYVATV SVLPELLREA
460 470
SPLQSLLEVL GLLGGVAMMV LIAHLE
Length:476
Mass (Da):50,657
Last modified:January 24, 2001 - v2
Checksum:i48214438BE44919B
GO

Sequence cautioni

The sequence AAA37767.1 differs from that shown. Reason: Frameshift at position 403. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081A → T in BAE35522. (PubMed:16141072)Curated
Sequence conflicti367 – 3671V → L in AAA37767. (PubMed:2294398)Curated
Sequence conflicti449 – 4502EA → DR in AAA37767. (PubMed:2294398)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32010 mRNA. Translation: AAA37767.1. Frameshift.
AF100956 Genomic DNA. Translation: AAC69903.1.
AK159968 mRNA. Translation: BAE35522.1.
CCDSiCCDS37576.1.
PIRiI49714.
RefSeqiNP_001071177.1. NM_001077709.1.
NP_032228.2. NM_008202.2.
UniGeneiMm.18556.

Genome annotation databases

EnsembliENSMUST00000025186; ENSMUSP00000025186; ENSMUSG00000024327.
ENSMUST00000169397; ENSMUSP00000130102; ENSMUSG00000024327.
GeneIDi14977.
KEGGimmu:14977.
UCSCiuc008cav.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32010 mRNA. Translation: AAA37767.1 . Frameshift.
AF100956 Genomic DNA. Translation: AAC69903.1 .
AK159968 mRNA. Translation: BAE35522.1 .
CCDSi CCDS37576.1.
PIRi I49714.
RefSeqi NP_001071177.1. NM_001077709.1.
NP_032228.2. NM_008202.2.
UniGenei Mm.18556.

3D structure databases

ProteinModelPortali Q31125.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q31125. 2 interactions.
MINTi MINT-1662266.

PTM databases

PhosphoSitei Q31125.

Proteomic databases

MaxQBi Q31125.
PaxDbi Q31125.
PRIDEi Q31125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025186 ; ENSMUSP00000025186 ; ENSMUSG00000024327 .
ENSMUST00000169397 ; ENSMUSP00000130102 ; ENSMUSG00000024327 .
GeneIDi 14977.
KEGGi mmu:14977.
UCSCi uc008cav.1. mouse.

Organism-specific databases

CTDi 7922.
MGIi MGI:95909. Slc39a7.

Phylogenomic databases

eggNOGi COG0428.
GeneTreei ENSGT00760000119115.
HOGENOMi HOG000185308.
HOVERGENi HBG001037.
InParanoidi Q31125.
KOi K14713.
OMAi FYISSVP.
OrthoDBi EOG73NG48.
PhylomeDBi Q31125.
TreeFami TF318470.

Enzyme and pathway databases

Reactomei REACT_198240. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSi Slc39a7. mouse.
NextBioi 287346.
PROi Q31125.
SOURCEi Search...

Gene expression databases

Bgeei Q31125.
ExpressionAtlasi Q31125. baseline.
Genevestigatori Q31125.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A putative transmembrane protein with histidine-rich charge clusters encoded in the H-2K/tw5 region of mice."
    St Jacques B., Han T.-H., Macmurray A., Shin H.-S.
    Mol. Cell. Biol. 10:138-145(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Sequence of the mouse major histocompatibility complex class II region."
    Rowen L., Qin S., Madan A., Loretz C., James R., Dors M., Mix L., Hall J., Lasky S., Hood L.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Osteoclast.
  4. "The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus."
    Huang L., Kirschke C.P., Zhang Y., Yu Y.Y.
    J. Biol. Chem. 280:15456-15463(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "A proteomics approach to identify the ubiquitinated proteins in mouse heart."
    Jeon H.B., Choi E.S., Yoon J.H., Hwang J.H., Chang J.W., Lee E.K., Choi H.W., Park Z.-Y., Yoo Y.J.
    Biochem. Biophys. Res. Commun. 357:731-736(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-317.
    Tissue: Heart.

Entry informationi

Entry nameiS39A7_MOUSE
AccessioniPrimary (citable) accession number: Q31125
Secondary accession number(s): Q3TVU6, Q9Z1W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 24, 2001
Last modified: November 26, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3