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Q31125

- S39A7_MOUSE

UniProt

Q31125 - S39A7_MOUSE

Protein

Zinc transporter SLC39A7

Gene

Slc39a7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (24 Jan 2001)
      Previous versions | rss
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    Functioni

    Zinc transporter, that transports Zn2+ from the endoplasmic reticulum/Golgi apparatus to the cytosol.1 Publication

    GO - Molecular functioni

    1. metal ion transmembrane transporter activity Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. zinc ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Transport, Zinc transport

    Keywords - Ligandi

    Zinc

    Enzyme and pathway databases

    ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc transporter SLC39A7
    Alternative name(s):
    Histidine-rich membrane protein Ke4
    Solute carrier family 39 member 7
    Zrt-, Irt-like protein 7
    Short name:
    ZIP7
    Gene namesi
    Name:Slc39a7
    Synonyms:H2-Ke4, Hke4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:95909. Slc39a7.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. Golgi apparatus Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476Zinc transporter SLC39A7PRO_0000213689Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei283 – 2831PhosphoserineBy similarity
    Cross-linki317 – 317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ31125.
    PRIDEiQ31125.

    PTM databases

    PhosphoSiteiQ31125.

    Expressioni

    Tissue specificityi

    Widely expressed.2 Publications

    Gene expression databases

    BgeeiQ31125.
    GenevestigatoriQ31125.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Tnfrsf1aP251183EBI-644519,EBI-518014

    Protein-protein interaction databases

    IntActiQ31125. 2 interactions.
    MINTiMINT-1662266.

    Structurei

    3D structure databases

    ProteinModelPortaliQ31125.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei177 – 19721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei222 – 24221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei393 – 41321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei417 – 43721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi27 – 136110His-richAdd
    BLAST
    Compositional biasi252 – 27423His-richAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0428.
    GeneTreeiENSGT00750000117326.
    HOGENOMiHOG000185308.
    HOVERGENiHBG001037.
    InParanoidiQ31125.
    KOiK14713.
    OMAiFYISSVP.
    OrthoDBiEOG73NG48.
    PhylomeDBiQ31125.
    TreeFamiTF318470.

    Family and domain databases

    InterProiIPR003689. ZIP.
    [Graphical view]
    PfamiPF02535. Zip. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q31125-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTMGLRAPHW VAVGLLTWAA LGLLVAGHEG HGDLHKDVEE DFHGHSHGHS    50
    HEDFHHGHSH GHSHEDFHHG HGHTHESIWH GHAHSHDHGH SREELHHGHS 100
    HGHSHDSLHH GGHGHAHREH SHGTSREAGA PGIKHHLDTV TLWAYALGAT 150
    VLISAAPFFV LFLIPVESNS PRHRSLLQIL LSFASGGLLG DAFLHLIPHA 200
    LEPHSHHAPE QPGHGHSHSG QGPILSVGLW VLSGIVAFLV VEKFVRHVKG 250
    GHGHSHGHGD RHAHGDSHTH GDRHECSSKE KPSTEEEKEV GGLRKRRGGN 300
    TGPRDGPVKP QSPEEEKAGS DLRVSGYLNL AADLAHNFTD GLAIGASFRG 350
    GRGLGILTTM TVLLHEVPHE VGDFAILVQS GCSKKQAMRL QLVTAIGALA 400
    GTACALLTEG GAVDSDVAGG AGPGWVLPFT AGGFIYVATV SVLPELLREA 450
    SPLQSLLEVL GLLGGVAMMV LIAHLE 476
    Length:476
    Mass (Da):50,657
    Last modified:January 24, 2001 - v2
    Checksum:i48214438BE44919B
    GO

    Sequence cautioni

    The sequence AAA37767.1 differs from that shown. Reason: Frameshift at position 403.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti208 – 2081A → T in BAE35522. (PubMed:16141072)Curated
    Sequence conflicti367 – 3671V → L in AAA37767. (PubMed:2294398)Curated
    Sequence conflicti449 – 4502EA → DR in AAA37767. (PubMed:2294398)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32010 mRNA. Translation: AAA37767.1. Frameshift.
    AF100956 Genomic DNA. Translation: AAC69903.1.
    AK159968 mRNA. Translation: BAE35522.1.
    CCDSiCCDS37576.1.
    PIRiI49714.
    RefSeqiNP_001071177.1. NM_001077709.1.
    NP_032228.2. NM_008202.2.
    UniGeneiMm.18556.

    Genome annotation databases

    EnsembliENSMUST00000025186; ENSMUSP00000025186; ENSMUSG00000024327.
    ENSMUST00000169397; ENSMUSP00000130102; ENSMUSG00000024327.
    GeneIDi14977.
    KEGGimmu:14977.
    UCSCiuc008cav.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M32010 mRNA. Translation: AAA37767.1 . Frameshift.
    AF100956 Genomic DNA. Translation: AAC69903.1 .
    AK159968 mRNA. Translation: BAE35522.1 .
    CCDSi CCDS37576.1.
    PIRi I49714.
    RefSeqi NP_001071177.1. NM_001077709.1.
    NP_032228.2. NM_008202.2.
    UniGenei Mm.18556.

    3D structure databases

    ProteinModelPortali Q31125.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q31125. 2 interactions.
    MINTi MINT-1662266.

    PTM databases

    PhosphoSitei Q31125.

    Proteomic databases

    PaxDbi Q31125.
    PRIDEi Q31125.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025186 ; ENSMUSP00000025186 ; ENSMUSG00000024327 .
    ENSMUST00000169397 ; ENSMUSP00000130102 ; ENSMUSG00000024327 .
    GeneIDi 14977.
    KEGGi mmu:14977.
    UCSCi uc008cav.1. mouse.

    Organism-specific databases

    CTDi 7922.
    MGIi MGI:95909. Slc39a7.

    Phylogenomic databases

    eggNOGi COG0428.
    GeneTreei ENSGT00750000117326.
    HOGENOMi HOG000185308.
    HOVERGENi HBG001037.
    InParanoidi Q31125.
    KOi K14713.
    OMAi FYISSVP.
    OrthoDBi EOG73NG48.
    PhylomeDBi Q31125.
    TreeFami TF318470.

    Enzyme and pathway databases

    Reactomei REACT_198240. Zinc influx into cells by the SLC39 gene family.

    Miscellaneous databases

    ChiTaRSi SLC39A7. mouse.
    NextBioi 287346.
    PROi Q31125.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q31125.
    Genevestigatori Q31125.

    Family and domain databases

    InterProi IPR003689. ZIP.
    [Graphical view ]
    Pfami PF02535. Zip. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A putative transmembrane protein with histidine-rich charge clusters encoded in the H-2K/tw5 region of mice."
      St Jacques B., Han T.-H., Macmurray A., Shin H.-S.
      Mol. Cell. Biol. 10:138-145(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Sequence of the mouse major histocompatibility complex class II region."
      Rowen L., Qin S., Madan A., Loretz C., James R., Dors M., Mix L., Hall J., Lasky S., Hood L.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129/SvJ.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Osteoclast.
    4. "The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus."
      Huang L., Kirschke C.P., Zhang Y., Yu Y.Y.
      J. Biol. Chem. 280:15456-15463(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    5. "A proteomics approach to identify the ubiquitinated proteins in mouse heart."
      Jeon H.B., Choi E.S., Yoon J.H., Hwang J.H., Chang J.W., Lee E.K., Choi H.W., Park Z.-Y., Yoo Y.J.
      Biochem. Biophys. Res. Commun. 357:731-736(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-317.
      Tissue: Heart.

    Entry informationi

    Entry nameiS39A7_MOUSE
    AccessioniPrimary (citable) accession number: Q31125
    Secondary accession number(s): Q3TVU6, Q9Z1W1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 24, 2001
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3