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Q31125

- S39A7_MOUSE

UniProt

Q31125 - S39A7_MOUSE

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Protein
Zinc transporter SLC39A7
Gene
Slc39a7, H2-Ke4, Hke4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Zinc transporter, that transports Zn2+ from the endoplasmic reticulum/Golgi apparatus to the cytosol.1 Publication

GO - Molecular functioni

  1. metal ion transmembrane transporter activity Source: InterPro
  2. protein binding Source: IntAct

GO - Biological processi

  1. zinc ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiREACT_198240. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter SLC39A7
Alternative name(s):
Histidine-rich membrane protein Ke4
Solute carrier family 39 member 7
Zrt-, Irt-like protein 7
Short name:
ZIP7
Gene namesi
Name:Slc39a7
Synonyms:H2-Ke4, Hke4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:95909. Slc39a7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST
Transmembranei146 – 16621Helical; Reviewed prediction
Add
BLAST
Transmembranei177 – 19721Helical; Reviewed prediction
Add
BLAST
Transmembranei222 – 24221Helical; Reviewed prediction
Add
BLAST
Transmembranei393 – 41321Helical; Reviewed prediction
Add
BLAST
Transmembranei417 – 43721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Zinc transporter SLC39A7
PRO_0000213689Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei283 – 2831Phosphoserine By similarity
Cross-linki317 – 317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ31125.
PRIDEiQ31125.

PTM databases

PhosphoSiteiQ31125.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiQ31125.
GenevestigatoriQ31125.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Tnfrsf1aP251183EBI-644519,EBI-518014

Protein-protein interaction databases

IntActiQ31125. 2 interactions.
MINTiMINT-1662266.

Structurei

3D structure databases

ProteinModelPortaliQ31125.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi27 – 136110His-rich
Add
BLAST
Compositional biasi252 – 27423His-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0428.
GeneTreeiENSGT00750000117326.
HOGENOMiHOG000185308.
HOVERGENiHBG001037.
InParanoidiQ31125.
KOiK14713.
OMAiFYISSVP.
OrthoDBiEOG73NG48.
PhylomeDBiQ31125.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q31125-1 [UniParc]FASTAAdd to Basket

« Hide

MTMGLRAPHW VAVGLLTWAA LGLLVAGHEG HGDLHKDVEE DFHGHSHGHS    50
HEDFHHGHSH GHSHEDFHHG HGHTHESIWH GHAHSHDHGH SREELHHGHS 100
HGHSHDSLHH GGHGHAHREH SHGTSREAGA PGIKHHLDTV TLWAYALGAT 150
VLISAAPFFV LFLIPVESNS PRHRSLLQIL LSFASGGLLG DAFLHLIPHA 200
LEPHSHHAPE QPGHGHSHSG QGPILSVGLW VLSGIVAFLV VEKFVRHVKG 250
GHGHSHGHGD RHAHGDSHTH GDRHECSSKE KPSTEEEKEV GGLRKRRGGN 300
TGPRDGPVKP QSPEEEKAGS DLRVSGYLNL AADLAHNFTD GLAIGASFRG 350
GRGLGILTTM TVLLHEVPHE VGDFAILVQS GCSKKQAMRL QLVTAIGALA 400
GTACALLTEG GAVDSDVAGG AGPGWVLPFT AGGFIYVATV SVLPELLREA 450
SPLQSLLEVL GLLGGVAMMV LIAHLE 476
Length:476
Mass (Da):50,657
Last modified:January 24, 2001 - v2
Checksum:i48214438BE44919B
GO

Sequence cautioni

The sequence AAA37767.1 differs from that shown. Reason: Frameshift at position 403.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti208 – 2081A → T in BAE35522. 1 Publication
Sequence conflicti367 – 3671V → L in AAA37767. 1 Publication
Sequence conflicti449 – 4502EA → DR in AAA37767. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32010 mRNA. Translation: AAA37767.1. Frameshift.
AF100956 Genomic DNA. Translation: AAC69903.1.
AK159968 mRNA. Translation: BAE35522.1.
CCDSiCCDS37576.1.
PIRiI49714.
RefSeqiNP_001071177.1. NM_001077709.1.
NP_032228.2. NM_008202.2.
UniGeneiMm.18556.

Genome annotation databases

EnsembliENSMUST00000025186; ENSMUSP00000025186; ENSMUSG00000024327.
ENSMUST00000169397; ENSMUSP00000130102; ENSMUSG00000024327.
GeneIDi14977.
KEGGimmu:14977.
UCSCiuc008cav.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M32010 mRNA. Translation: AAA37767.1 . Frameshift.
AF100956 Genomic DNA. Translation: AAC69903.1 .
AK159968 mRNA. Translation: BAE35522.1 .
CCDSi CCDS37576.1.
PIRi I49714.
RefSeqi NP_001071177.1. NM_001077709.1.
NP_032228.2. NM_008202.2.
UniGenei Mm.18556.

3D structure databases

ProteinModelPortali Q31125.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q31125. 2 interactions.
MINTi MINT-1662266.

PTM databases

PhosphoSitei Q31125.

Proteomic databases

PaxDbi Q31125.
PRIDEi Q31125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025186 ; ENSMUSP00000025186 ; ENSMUSG00000024327 .
ENSMUST00000169397 ; ENSMUSP00000130102 ; ENSMUSG00000024327 .
GeneIDi 14977.
KEGGi mmu:14977.
UCSCi uc008cav.1. mouse.

Organism-specific databases

CTDi 7922.
MGIi MGI:95909. Slc39a7.

Phylogenomic databases

eggNOGi COG0428.
GeneTreei ENSGT00750000117326.
HOGENOMi HOG000185308.
HOVERGENi HBG001037.
InParanoidi Q31125.
KOi K14713.
OMAi FYISSVP.
OrthoDBi EOG73NG48.
PhylomeDBi Q31125.
TreeFami TF318470.

Enzyme and pathway databases

Reactomei REACT_198240. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSi SLC39A7. mouse.
NextBioi 287346.
PROi Q31125.
SOURCEi Search...

Gene expression databases

Bgeei Q31125.
Genevestigatori Q31125.

Family and domain databases

InterProi IPR003689. ZIP.
[Graphical view ]
Pfami PF02535. Zip. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A putative transmembrane protein with histidine-rich charge clusters encoded in the H-2K/tw5 region of mice."
    St Jacques B., Han T.-H., Macmurray A., Shin H.-S.
    Mol. Cell. Biol. 10:138-145(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Sequence of the mouse major histocompatibility complex class II region."
    Rowen L., Qin S., Madan A., Loretz C., James R., Dors M., Mix L., Hall J., Lasky S., Hood L.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Osteoclast.
  4. "The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus."
    Huang L., Kirschke C.P., Zhang Y., Yu Y.Y.
    J. Biol. Chem. 280:15456-15463(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "A proteomics approach to identify the ubiquitinated proteins in mouse heart."
    Jeon H.B., Choi E.S., Yoon J.H., Hwang J.H., Chang J.W., Lee E.K., Choi H.W., Park Z.-Y., Yoo Y.J.
    Biochem. Biophys. Res. Commun. 357:731-736(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-317.
    Tissue: Heart.

Entry informationi

Entry nameiS39A7_MOUSE
AccessioniPrimary (citable) accession number: Q31125
Secondary accession number(s): Q3TVU6, Q9Z1W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 24, 2001
Last modified: September 3, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi