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Protein

Zinc transporter SLC39A7

Gene

Slc39a7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Zinc transporter, that transports Zn2+ from the endoplasmic reticulum/Golgi apparatus to the cytosol.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter SLC39A7
Alternative name(s):
Histidine-rich membrane protein Ke4
Solute carrier family 39 member 7
Zrt-, Irt-like protein 7
Short name:
ZIP7
Gene namesi
Name:Slc39a7
Synonyms:H2-Ke4, Hke4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95909. Slc39a7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Transmembranei393 – 413HelicalSequence analysisAdd BLAST21
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002136891 – 476Zinc transporter SLC39A7Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei283PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ31125.
MaxQBiQ31125.
PaxDbiQ31125.
PRIDEiQ31125.

PTM databases

iPTMnetiQ31125.
PhosphoSitePlusiQ31125.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSMUSG00000024327.
ExpressionAtlasiQ31125. baseline and differential.
GenevisibleiQ31125. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Tnfrsf1aP251183EBI-644519,EBI-518014

Protein-protein interaction databases

IntActiQ31125. 3 interactors.
MINTiMINT-1662266.
STRINGi10090.ENSMUSP00000025186.

Structurei

3D structure databases

ProteinModelPortaliQ31125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 136His-richAdd BLAST110
Compositional biasi252 – 274His-richAdd BLAST23

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000185308.
HOVERGENiHBG001037.
InParanoidiQ31125.
KOiK14713.
OMAiQEDFHGH.
OrthoDBiEOG091G0GD1.
PhylomeDBiQ31125.
TreeFamiTF318470.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q31125-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMGLRAPHW VAVGLLTWAA LGLLVAGHEG HGDLHKDVEE DFHGHSHGHS
60 70 80 90 100
HEDFHHGHSH GHSHEDFHHG HGHTHESIWH GHAHSHDHGH SREELHHGHS
110 120 130 140 150
HGHSHDSLHH GGHGHAHREH SHGTSREAGA PGIKHHLDTV TLWAYALGAT
160 170 180 190 200
VLISAAPFFV LFLIPVESNS PRHRSLLQIL LSFASGGLLG DAFLHLIPHA
210 220 230 240 250
LEPHSHHAPE QPGHGHSHSG QGPILSVGLW VLSGIVAFLV VEKFVRHVKG
260 270 280 290 300
GHGHSHGHGD RHAHGDSHTH GDRHECSSKE KPSTEEEKEV GGLRKRRGGN
310 320 330 340 350
TGPRDGPVKP QSPEEEKAGS DLRVSGYLNL AADLAHNFTD GLAIGASFRG
360 370 380 390 400
GRGLGILTTM TVLLHEVPHE VGDFAILVQS GCSKKQAMRL QLVTAIGALA
410 420 430 440 450
GTACALLTEG GAVDSDVAGG AGPGWVLPFT AGGFIYVATV SVLPELLREA
460 470
SPLQSLLEVL GLLGGVAMMV LIAHLE
Length:476
Mass (Da):50,657
Last modified:January 24, 2001 - v2
Checksum:i48214438BE44919B
GO

Sequence cautioni

The sequence AAA37767 differs from that shown. Reason: Frameshift at position 403.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208A → T in BAE35522 (PubMed:16141072).Curated1
Sequence conflicti367V → L in AAA37767 (PubMed:2294398).Curated1
Sequence conflicti449 – 450EA → DR in AAA37767 (PubMed:2294398).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32010 mRNA. Translation: AAA37767.1. Frameshift.
AF100956 Genomic DNA. Translation: AAC69903.1.
AK159968 mRNA. Translation: BAE35522.1.
CCDSiCCDS37576.1.
PIRiI49714.
RefSeqiNP_001071177.1. NM_001077709.1.
NP_032228.2. NM_008202.2.
UniGeneiMm.18556.

Genome annotation databases

EnsembliENSMUST00000025186; ENSMUSP00000025186; ENSMUSG00000024327.
ENSMUST00000169397; ENSMUSP00000130102; ENSMUSG00000024327.
GeneIDi14977.
KEGGimmu:14977.
UCSCiuc008cav.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M32010 mRNA. Translation: AAA37767.1. Frameshift.
AF100956 Genomic DNA. Translation: AAC69903.1.
AK159968 mRNA. Translation: BAE35522.1.
CCDSiCCDS37576.1.
PIRiI49714.
RefSeqiNP_001071177.1. NM_001077709.1.
NP_032228.2. NM_008202.2.
UniGeneiMm.18556.

3D structure databases

ProteinModelPortaliQ31125.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ31125. 3 interactors.
MINTiMINT-1662266.
STRINGi10090.ENSMUSP00000025186.

PTM databases

iPTMnetiQ31125.
PhosphoSitePlusiQ31125.

Proteomic databases

EPDiQ31125.
MaxQBiQ31125.
PaxDbiQ31125.
PRIDEiQ31125.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025186; ENSMUSP00000025186; ENSMUSG00000024327.
ENSMUST00000169397; ENSMUSP00000130102; ENSMUSG00000024327.
GeneIDi14977.
KEGGimmu:14977.
UCSCiuc008cav.1. mouse.

Organism-specific databases

CTDi7922.
MGIiMGI:95909. Slc39a7.

Phylogenomic databases

eggNOGiKOG2693. Eukaryota.
COG0428. LUCA.
GeneTreeiENSGT00760000119115.
HOGENOMiHOG000185308.
HOVERGENiHBG001037.
InParanoidiQ31125.
KOiK14713.
OMAiQEDFHGH.
OrthoDBiEOG091G0GD1.
PhylomeDBiQ31125.
TreeFamiTF318470.

Enzyme and pathway databases

ReactomeiR-MMU-442380. Zinc influx into cells by the SLC39 gene family.

Miscellaneous databases

ChiTaRSiSlc39a7. mouse.
PROiQ31125.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024327.
ExpressionAtlasiQ31125. baseline and differential.
GenevisibleiQ31125. MM.

Family and domain databases

InterProiIPR003689. ZIP.
[Graphical view]
PfamiPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS39A7_MOUSE
AccessioniPrimary (citable) accession number: Q31125
Secondary accession number(s): Q3TVU6, Q9Z1W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 24, 2001
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.