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Q31125 (S39A7_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc transporter SLC39A7
Alternative name(s):
Histidine-rich membrane protein Ke4
Solute carrier family 39 member 7
Zrt-, Irt-like protein 7
Short name=ZIP7
Gene names
Name:Slc39a7
Synonyms:H2-Ke4, Hke4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Zinc transporter, that transports Zn2+ from the endoplasmic reticulum/Golgi apparatus to the cytosol. Ref.4

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity. Golgi apparatuscis-Golgi network membrane By similarity.

Tissue specificity

Widely expressed. Ref.1 Ref.4

Sequence similarities

Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. [View classification]

Sequence caution

The sequence AAA37767.1 differs from that shown. Reason: Frameshift at position 403.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Tnfrsf1aP251183EBI-644519,EBI-518014

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 476476Zinc transporter SLC39A7
PRO_0000213689

Regions

Transmembrane7 – 2721Helical; Potential
Transmembrane146 – 16621Helical; Potential
Transmembrane177 – 19721Helical; Potential
Transmembrane222 – 24221Helical; Potential
Transmembrane393 – 41321Helical; Potential
Transmembrane417 – 43721Helical; Potential
Compositional bias27 – 136110His-rich
Compositional bias252 – 27423His-rich

Amino acid modifications

Modified residue2831Phosphoserine By similarity
Cross-link317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.5

Experimental info

Sequence conflict2081A → T in BAE35522. Ref.3
Sequence conflict3671V → L in AAA37767. Ref.1
Sequence conflict449 – 4502EA → DR in AAA37767. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q31125 [UniParc].

Last modified January 24, 2001. Version 2.
Checksum: 48214438BE44919B

FASTA47650,657
        10         20         30         40         50         60 
MTMGLRAPHW VAVGLLTWAA LGLLVAGHEG HGDLHKDVEE DFHGHSHGHS HEDFHHGHSH 

        70         80         90        100        110        120 
GHSHEDFHHG HGHTHESIWH GHAHSHDHGH SREELHHGHS HGHSHDSLHH GGHGHAHREH 

       130        140        150        160        170        180 
SHGTSREAGA PGIKHHLDTV TLWAYALGAT VLISAAPFFV LFLIPVESNS PRHRSLLQIL 

       190        200        210        220        230        240 
LSFASGGLLG DAFLHLIPHA LEPHSHHAPE QPGHGHSHSG QGPILSVGLW VLSGIVAFLV 

       250        260        270        280        290        300 
VEKFVRHVKG GHGHSHGHGD RHAHGDSHTH GDRHECSSKE KPSTEEEKEV GGLRKRRGGN 

       310        320        330        340        350        360 
TGPRDGPVKP QSPEEEKAGS DLRVSGYLNL AADLAHNFTD GLAIGASFRG GRGLGILTTM 

       370        380        390        400        410        420 
TVLLHEVPHE VGDFAILVQS GCSKKQAMRL QLVTAIGALA GTACALLTEG GAVDSDVAGG 

       430        440        450        460        470 
AGPGWVLPFT AGGFIYVATV SVLPELLREA SPLQSLLEVL GLLGGVAMMV LIAHLE 

« Hide

References

« Hide 'large scale' references
[1]"A putative transmembrane protein with histidine-rich charge clusters encoded in the H-2K/tw5 region of mice."
St Jacques B., Han T.-H., Macmurray A., Shin H.-S.
Mol. Cell. Biol. 10:138-145(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Sequence of the mouse major histocompatibility complex class II region."
Rowen L., Qin S., Madan A., Loretz C., James R., Dors M., Mix L., Hall J., Lasky S., Hood L.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 129/SvJ.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Osteoclast.
[4]"The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus."
Huang L., Kirschke C.P., Zhang Y., Yu Y.Y.
J. Biol. Chem. 280:15456-15463(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
[5]"A proteomics approach to identify the ubiquitinated proteins in mouse heart."
Jeon H.B., Choi E.S., Yoon J.H., Hwang J.H., Chang J.W., Lee E.K., Choi H.W., Park Z.-Y., Yoo Y.J.
Biochem. Biophys. Res. Commun. 357:731-736(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-317.
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M32010 mRNA. Translation: AAA37767.1. Frameshift.
AF100956 Genomic DNA. Translation: AAC69903.1.
AK159968 mRNA. Translation: BAE35522.1.
CCDSCCDS37576.1.
PIRI49714.
RefSeqNP_001071177.1. NM_001077709.1.
NP_032228.2. NM_008202.2.
UniGeneMm.18556.

3D structure databases

ProteinModelPortalQ31125.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ31125. 2 interactions.
MINTMINT-1662266.

PTM databases

PhosphoSiteQ31125.

Proteomic databases

PaxDbQ31125.
PRIDEQ31125.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025186; ENSMUSP00000025186; ENSMUSG00000024327.
ENSMUST00000169397; ENSMUSP00000130102; ENSMUSG00000024327.
GeneID14977.
KEGGmmu:14977.
UCSCuc008cav.1. mouse.

Organism-specific databases

CTD7922.
MGIMGI:95909. Slc39a7.

Phylogenomic databases

eggNOGCOG0428.
GeneTreeENSGT00750000117326.
HOGENOMHOG000185308.
HOVERGENHBG001037.
InParanoidQ31125.
KOK14713.
OMAFYISSVP.
OrthoDBEOG73NG48.
PhylomeDBQ31125.
TreeFamTF318470.

Gene expression databases

BgeeQ31125.
GenevestigatorQ31125.

Family and domain databases

InterProIPR003689. ZIP.
[Graphical view]
PfamPF02535. Zip. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC39A7. mouse.
NextBio287346.
PROQ31125.
SOURCESearch...

Entry information

Entry nameS39A7_MOUSE
AccessionPrimary (citable) accession number: Q31125
Secondary accession number(s): Q3TVU6, Q9Z1W1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 24, 2001
Last modified: July 9, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot