ID   Q31094_MOUSE            Unreviewed;       261 AA.
AC   Q31094;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1999, sequence version 2.
DT   27-MAR-2024, entry version 204.
DE   SubName: Full=H2-M beta1 {ECO:0000313|EMBL:AAC69909.1};
DE   SubName: Full=Histocompatibility 2, class II, locus Mb1 {ECO:0000313|EMBL:AAH03718.1, ECO:0000313|Ensembl:ENSMUSP00000109870.3};
DE   SubName: Full=MHC class II antigen Mb1 {ECO:0000313|EMBL:AIC84013.1};
GN   Name=H2-DMb1 {ECO:0000313|EMBL:AAH03718.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000109870.3, ECO:0000313|MGI:MGI:95922};
GN   Synonyms=H2-DMb2 {ECO:0000313|MGI:MGI:95922}, H2-M beta1
GN   {ECO:0000313|EMBL:AAC69909.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAC69909.1};
RN   [1] {ECO:0000313|EMBL:AAC69909.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129svj {ECO:0000313|EMBL:AAC69909.1};
RA   Rowen L., Qin S., Madan A., Loretz C., James R., Dors M., Mix L., Hall J.,
RA   Lasky S., Hood L.;
RT   "Sequence of the mouse major histocomaptibility locus class II region.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BAC28006.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC28006.1};
RC   TISSUE=Wolffian duct includes surrounding region
RC   {ECO:0000313|EMBL:BAC28006.1};
RX   PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [3] {ECO:0000313|EMBL:BAC28006.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC28006.1};
RC   TISSUE=Wolffian duct includes surrounding region
RC   {ECO:0000313|EMBL:BAC28006.1};
RX   PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT   full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [4] {ECO:0000313|EMBL:BAC28006.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC28006.1};
RC   TISSUE=Wolffian duct includes surrounding region
RC   {ECO:0000313|EMBL:BAC28006.1};
RX   PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA   Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA   Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA   Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA   Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA   Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT   pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [5] {ECO:0000313|EMBL:BAC28006.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC28006.1};
RC   TISSUE=Wolffian duct includes surrounding region
RC   {ECO:0000313|EMBL:BAC28006.1};
RX   PubMed=11217851; DOI=10.1038/35055500;
RG   The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [6] {ECO:0000313|EMBL:BAC28006.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC28006.1};
RC   TISSUE=Wolffian duct includes surrounding region
RC   {ECO:0000313|EMBL:BAC28006.1};
RA   Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA   Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA   Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA   Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA   Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA   Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA   Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA   Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA   Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA   Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA   Hayashizaki Y.;
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:BAC28006.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC28006.1};
RC   TISSUE=Wolffian duct includes surrounding region
RC   {ECO:0000313|EMBL:BAC28006.1};
RX   PubMed=12466851; DOI=10.1038/nature01266;
RG   The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [8] {ECO:0000313|EMBL:AAH03718.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Mix FVB/N {ECO:0000313|EMBL:AAH03718.1};
RC   TISSUE=Mammary tumor. WAP-TGF alpha model. 7 months old
RC   {ECO:0000313|EMBL:AAH03718.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [9] {ECO:0000313|EMBL:BAC28006.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC28006.1};
RC   TISSUE=Wolffian duct includes surrounding region
RC   {ECO:0000313|EMBL:BAC28006.1};
RG   The FANTOM Consortium;
RG   Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT   "The Transcriptional Landscape of the Mammalian Genome.";
RL   Science 309:1559-1563(2005).
RN   [10] {ECO:0000313|EMBL:BAC28006.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC28006.1};
RC   TISSUE=Wolffian duct includes surrounding region
RC   {ECO:0000313|EMBL:BAC28006.1};
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [11] {ECO:0000313|Ensembl:ENSMUSP00000109870.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109870.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [12] {ECO:0000313|EMBL:AIC84013.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=I/StSnEgYCit {ECO:0000313|EMBL:AIC84013.1};
RC   TISSUE=Spleen {ECO:0000313|EMBL:AIC84013.1};
RA   Harrison E.;
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:AIC84013.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=I/StSnEgYCit {ECO:0000313|EMBL:AIC84013.1};
RC   TISSUE=Spleen {ECO:0000313|EMBL:AIC84013.1};
RX   PubMed=26618355;
RA   Logunova N., Korotetskaya M., Polshakov V., Apt A.;
RT   "The QTL within the H2 Complex Involved in the Control of Tuberculosis
RT   Infection in Mice Is the Classical Class II H2-Ab1 Gene.";
RL   PLoS Genet. 11:E1005672-E1005672(2015).
RN   [14] {ECO:0000313|Ensembl:ENSMUSP00000109870.3}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000109870.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the MHC class II family.
CC       {ECO:0000256|ARBA:ARBA00007394}.
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DR   EMBL; AF100956; AAC69909.1; -; Genomic_DNA.
DR   EMBL; BC003718; AAH03718.1; -; mRNA.
DR   EMBL; KJ650225; AIC84013.1; -; mRNA.
DR   EMBL; AK032745; BAC28006.1; -; mRNA.
DR   RefSeq; NP_034517.2; NM_010387.3.
DR   ProteomicsDB; 334717; -.
DR   DNASU; 14999; -.
DR   Ensembl; ENSMUST00000114232.4; ENSMUSP00000109870.3; ENSMUSG00000079547.5.
DR   GeneID; 14999; -.
DR   KEGG; mmu:14999; -.
DR   UCSC; uc008cbq.1; mouse.
DR   AGR; MGI:95922; -.
DR   CTD; 14999; -.
DR   MGI; MGI:95922; H2-DMb1.
DR   VEuPathDB; HostDB:ENSMUSG00000079547; -.
DR   GeneTree; ENSGT00940000160381; -.
DR   HOGENOM; CLU_092834_0_0_1; -.
DR   OMA; MTEDWSY; -.
DR   OrthoDB; 4118190at2759; -.
DR   TreeFam; TF335727; -.
DR   BioGRID-ORCS; 14999; 2 hits in 81 CRISPR screens.
DR   ChiTaRS; H2-DMb1; mouse.
DR   Proteomes; UP000000589; Chromosome 17.
DR   Bgee; ENSMUSG00000079547; Expressed in mesenteric lymph node and 112 other cell types or tissues.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IEA:UniProt.
DR   CDD; cd21002; IgC1_MHC_II_beta_HLA-DM; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   PANTHER; PTHR19944:SF65; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM BETA CHAIN; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   MHC II {ECO:0000256|ARBA:ARBA00023182};
KW   Proteomics identification {ECO:0007829|EPD:Q31094,
KW   ECO:0007829|MaxQB:Q31094};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..261
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015097375"
FT   TRANSMEM        219..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          115..204
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   261 AA;  28914 MW;  50203DECC9E1888A CRC64;
     MAALWLLLLV LSLDCMGAGG FVAHVESTCV LDDAGTPQDF TYCVSFNKDL LACWDPDVGK
     IVPCEFGVLY PWAENFSRIL NKEESLLQRL QNGLLDCASH TQPFWNALTH RTRAPSVRVA
     QTTPFNTREP VMLACYVWGF YPADVTITWM KNGQLVPSHS NKEKTAQPNG DWTYQTVSYL
     ALTPSYGDVY TCVVQHSGTS EPIRGDWTPG LSPIQTVKVS VSAATLGLGF IIFCVGFFRW
     RKSHSSSYTP LSGSTYPEGQ H
//