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Protein
Submitted name:

Class II histocompatibility antigen, M beta 1 chain

Gene

H2-DMb1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.

Names & Taxonomyi

Protein namesi
Submitted name:
Class II histocompatibility antigen, M beta 1 chainImported
Submitted name:
H2-M beta1Imported
Submitted name:
Histocompatibility 2, class II, locus Mb1Imported
Submitted name:
MHC class II antigen Mb1Imported
Gene namesi
Name:H2-DMb1Imported
Synonyms:H2-DMb2Imported, H2-M beta1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95922. H2-DMb1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei219 – 23820HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 261241Sequence analysisPRO_5007923442Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000079547.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109870.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini115 – 20490Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IFNH. Eukaryota.
ENOG410YU9X. LUCA.
GeneTreeiENSGT00760000118970.
HOVERGENiHBG007327.
KOiK06752.
OMAiCASHTQP.
OrthoDBiEOG091G0G84.
TreeFamiTF335727.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q31094-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALWLLLLV LSLDCMGAGG FVAHVESTCV LDDAGTPQDF TYCVSFNKDL
60 70 80 90 100
LACWDPDVGK IVPCEFGVLY PWAENFSRIL NKEESLLQRL QNGLLDCASH
110 120 130 140 150
TQPFWNALTH RTRAPSVRVA QTTPFNTREP VMLACYVWGF YPADVTITWM
160 170 180 190 200
KNGQLVPSHS NKEKTAQPNG DWTYQTVSYL ALTPSYGDVY TCVVQHSGTS
210 220 230 240 250
EPIRGDWTPG LSPIQTVKVS VSAATLGLGF IIFCVGFFRW RKSHSSSYTP
260
LSGSTYPEGQ H
Length:261
Mass (Da):28,914
Last modified:August 1, 1999 - v2
Checksum:i50203DECC9E1888A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974422 Genomic DNA. No translation available.
AF100956 Genomic DNA. Translation: AAC69909.1.
BC003718 mRNA. Translation: AAH03718.1.
KJ650225 mRNA. Translation: AIC84013.1.
AK032745 mRNA. Translation: BAC28006.1.
RefSeqiNP_034517.2. NM_010387.3.
UniGeneiMm.460938.

Genome annotation databases

EnsembliENSMUST00000114232; ENSMUSP00000109870; ENSMUSG00000079547.
GeneIDi14999.
KEGGimmu:14999.
UCSCiuc008cbq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974422 Genomic DNA. No translation available.
AF100956 Genomic DNA. Translation: AAC69909.1.
BC003718 mRNA. Translation: AAH03718.1.
KJ650225 mRNA. Translation: AIC84013.1.
AK032745 mRNA. Translation: BAC28006.1.
RefSeqiNP_034517.2. NM_010387.3.
UniGeneiMm.460938.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109870.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114232; ENSMUSP00000109870; ENSMUSG00000079547.
GeneIDi14999.
KEGGimmu:14999.
UCSCiuc008cbq.1. mouse.

Organism-specific databases

CTDi14999.
MGIiMGI:95922. H2-DMb1.

Phylogenomic databases

eggNOGiENOG410IFNH. Eukaryota.
ENOG410YU9X. LUCA.
GeneTreeiENSGT00760000118970.
HOVERGENiHBG007327.
KOiK06752.
OMAiCASHTQP.
OrthoDBiEOG091G0G84.
TreeFamiTF335727.

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.

Miscellaneous databases

ChiTaRSiHbb-b1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079547.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ31094_MOUSE
AccessioniPrimary (citable) accession number: Q31094
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: August 1, 1999
Last modified: September 7, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.