ID Q31065_PIG Unreviewed; 252 AA. AC Q31065; A0A8D1H5T7; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 27-MAR-2024, entry version 156. DE SubName: Full=MHC class II DR-alpha {ECO:0000313|EMBL:AAA31075.1, ECO:0000313|Ensembl:ENSSSCP00005018427.1}; DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:AAO63765.1, ECO:0000313|EMBL:ABK96887.1}; GN Name=SLA-DR-alpha {ECO:0000313|EMBL:AAA31075.1}; GN Synonyms=DRA {ECO:0000313|EMBL:ASO67465.1}, SLA-DRA GN {ECO:0000313|EMBL:ABI31830.1, GN ECO:0000313|Ensembl:ENSSSCP00005018427.1}, SLA-DRA1 GN {ECO:0000313|EMBL:AAO63765.1}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823 {ECO:0000313|EMBL:AAA31075.1}; RN [1] {ECO:0000313|EMBL:AAA31075.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Minnesota miniature swine {ECO:0000313|EMBL:AAA31075.1}; RC TISSUE=Spleen and blood {ECO:0000313|EMBL:AAA31075.1}; RX PubMed=1634772; RA Hirsch F., Germana S., Gustafsson K., Pratt K., Sachs D.H., Leguern C.; RT "Structure and expression of class II alpha genes in miniature swine."; RL J. Immunol. 149:841-846(1992). RN [2] {ECO:0000313|EMBL:AAO63765.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15713212; DOI=10.1111/j.1399-0039.2005.00337.x; RA Smith D.M., Lunney J.K., Martens G.W., Ando A., Lee J.H., Ho C.S., RA Schook L., Renard C., Chardon P.; RT "Nomenclature for factors of the SLA class-I system, 2004."; RL Tissue Antigens 65:136-149(2005). RN [3] {ECO:0000313|EMBL:ABK96887.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Ear {ECO:0000313|EMBL:ABK96887.1}; RA Tang Y., Xing X., Wang W.; RT "Characterization and clone of Hunan Shaziling pig DR gene."; RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:ABI31830.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18549392; DOI=10.1111/j.1744-313X.2008.00775.x; RA Lee Y.J., Cho K.H., Kim M.J., Smith D.M., Ho C.S., Jung K.C., Jin D.I., RA Park C.S., Jeon J.T., Lee J.H.; RT "Sequence-based characterization of the eight SLA loci in Korean native RT pigs."; RL Int. J. Immunogenet. 35:333-334(2008). RN [5] {ECO:0000313|EMBL:ACE07020.1} RP NUCLEOTIDE SEQUENCE. RA Yeom S.C., Park C.G., Lee B.C., Lee W.J.; RT "Sequence base SLA typing in CMS miniature pig."; RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:ADB82916.1} RP NUCLEOTIDE SEQUENCE. RA Mo S., Jing Z., Fang Y., Feng H.; RT "cDNA cloning, genomic structure and genetic polymorphism of swine MHC RT class I and II genes in Chinese mini pig."; RL Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:ANB43752.1} RP NUCLEOTIDE SEQUENCE. RA Huang X., Gun S., Yang Q., Yuan J.; RT "Polymorphisms in the SLA-DQA and DRA Gene Exon 2 and their Association RT with Piglet Diarrhea in Chinese Yantai Black Pig."; RL Philipp Agric Sci 98:253-261(2015). RN [8] {ECO:0000313|EMBL:ASO67465.1} RP NUCLEOTIDE SEQUENCE. RA Gao C., Wang X., Quan J., Wang J., Tang X., Chen H.; RT "Molecular characterization of swine leukocyte antigen (SLA) gene diversity RT in Chinese Rongshui miniature pigs."; RL Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases. RN [9] {ECO:0000313|EMBL:WAI89218.1} RP NUCLEOTIDE SEQUENCE. RA Liu H., Luo T., Li C., Chen H., Xia C., Gao C.; RL Submitted (AUG-2022) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|Ensembl:ENSSSCP00005018427.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2023) to UniProtKB. CC -!- SIMILARITY: Belongs to the MHC class II family. CC {ECO:0000256|RuleBase:RU004238}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M93028; AAA31075.1; -; mRNA. DR EMBL; AY247783; AAO63765.1; -; mRNA. DR EMBL; AY285926; AAP37550.1; -; mRNA. DR EMBL; AY285935; AAP37559.1; -; mRNA. DR EMBL; AY285937; AAP37561.1; -; mRNA. DR EMBL; DQ883223; ABI31830.1; -; mRNA. DR EMBL; EF143987; ABK96887.1; -; mRNA. DR EMBL; EU722918; ACE07020.1; -; mRNA. DR EMBL; FJ905836; ADB82916.1; -; Genomic_DNA. DR EMBL; KU052696; ANB43752.1; -; mRNA. DR EMBL; KU052698; ANB43754.1; -; mRNA. DR EMBL; MF498818; ASO67465.1; -; mRNA. DR EMBL; OP249523; WAI89218.1; -; mRNA. DR PIR; A46505; A46505. DR RefSeq; NP_001107178.1; NM_001113706.1. DR SMR; Q31065; -. DR Ensembl; ENSSSCT00005030209.1; ENSSSCP00005018427.1; ENSSSCG00005019045.1. DR GeneID; 100135040; -. DR KEGG; ssc:100135040; -. DR CTD; 100135040; -. DR OrthoDB; 4118190at2759; -. DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR014745; MHC_II_a/b_N. DR InterPro; IPR001003; MHC_II_a_N. DR PANTHER; PTHR19944:SF86; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN; 1. DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00993; MHC_II_alpha; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00920; MHC_II_alpha; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 2: Evidence at transcript level; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW MHC II {ECO:0000256|ARBA:ARBA00023182}; Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..23 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 24..252 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5011098541" FT TRANSMEM 219..240 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 110..190 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" SQ SEQUENCE 252 AA; 28382 MW; F47D022AB8D44A82 CRC64; MTILGVPVLG FVITILNLQK SWAIVENHVI IQAEFYLSPD KSGEFMFDFD GDEIFHVDME KRETVWRLEE FGHFASFEAQ GALANIAVDK ANLEILIKRS NNTPNTNVPP EVTVLSDKPV ELGEPNILIC FIDKFSPPVV NVTWLRNGSP VTRGVSETVF LPREDHLFRK FHYLPFMPST EDVYDCQVEH WGLDKPLLKH WEFEAQTPLP ETTENTVCAL GLIVALVGII VGTVLIIKGV RKGNATERRG PL //