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Protein
Submitted name:

MHC class II DR-alpha

Gene

SLA-DR-alpha

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II DR-alphaImported
Submitted name:
MHC class II antigenImported
Submitted name:
MHC class II antigen DR-alphaImported
Gene namesi
Name:SLA-DR-alphaImported
Synonyms:SLA-DRAImported, SLA-DRA1Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei219 – 24022HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 252229Sequence analysisPRO_5007701793Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001567.

Structurei

3D structure databases

SMRiQ31065. Positions 26-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini110 – 19081Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotationSAAS annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IZMF. Eukaryota.
ENOG410YHX9. LUCA.
HOVERGENiHBG006862.
KOiK06752.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q31065-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTILGVPVLG FVITILNLQK SWAIVENHVI IQAEFYLSPD KSGEFMFDFD
60 70 80 90 100
GDEIFHVDME KRETVWRLEE FGHFASFEAQ GALANIAVDK ANLEILIKRS
110 120 130 140 150
NNTPNTNVPP EVTVLSDKPV ELGEPNILIC FIDKFSPPVV NVTWLRNGSP
160 170 180 190 200
VTRGVSETVF LPREDHLFRK FHYLPFMPST EDVYDCQVEH WGLDKPLLKH
210 220 230 240 250
WEFEAQTPLP ETTENTVCAL GLIVALVGII VGTVLIIKGV RKGNATERRG

PL
Length:252
Mass (Da):28,382
Last modified:November 1, 1996 - v1
Checksum:iF47D022AB8D44A82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93028 mRNA. Translation: AAA31075.1.
AY247783 mRNA. Translation: AAO63765.1.
AY285926 mRNA. Translation: AAP37550.1.
AY285935 mRNA. Translation: AAP37559.1.
AY285937 mRNA. Translation: AAP37561.1.
DQ883223 mRNA. Translation: ABI31830.1.
EF143987 mRNA. Translation: ABK96887.1.
EU722918 mRNA. Translation: ACE07020.1.
FJ905836 Genomic DNA. Translation: ADB82916.1.
KU052696 mRNA. Translation: ANB43752.1.
KU052698 mRNA. Translation: ANB43754.1.
PIRiA46505.
RefSeqiNP_001107178.1. NM_001113706.1.
UniGeneiSsc.222.

Genome annotation databases

GeneIDi100135040.
KEGGissc:100135040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93028 mRNA. Translation: AAA31075.1.
AY247783 mRNA. Translation: AAO63765.1.
AY285926 mRNA. Translation: AAP37550.1.
AY285935 mRNA. Translation: AAP37559.1.
AY285937 mRNA. Translation: AAP37561.1.
DQ883223 mRNA. Translation: ABI31830.1.
EF143987 mRNA. Translation: ABK96887.1.
EU722918 mRNA. Translation: ACE07020.1.
FJ905836 Genomic DNA. Translation: ADB82916.1.
KU052696 mRNA. Translation: ANB43752.1.
KU052698 mRNA. Translation: ANB43754.1.
PIRiA46505.
RefSeqiNP_001107178.1. NM_001113706.1.
UniGeneiSsc.222.

3D structure databases

SMRiQ31065. Positions 26-205.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100135040.
KEGGissc:100135040.

Organism-specific databases

CTDi100135040.

Phylogenomic databases

eggNOGiENOG410IZMF. Eukaryota.
ENOG410YHX9. LUCA.
HOVERGENiHBG006862.
KOiK06752.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ31065_PIG
AccessioniPrimary (citable) accession number: Q31065
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.