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Protein
Submitted name:

MHC class II DR-alpha

Gene

SLA-DR-alpha

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II DR-alphaImported
Submitted name:
MHC class II antigenImported
Submitted name:
MHC class II antigen DR-alphaImported
Gene namesi
Name:SLA-DR-alphaImported
Synonyms:SLA-DRAImported, SLA-DRA1Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. MHC class II protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 PotentialImportedAdd
BLAST
Chaini23 – 252230MHC class II DR-alphaImportedPRO_5000143831Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ31065.
SMRiQ31065. Positions 26-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG006862.
KOiK06752.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q31065-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTILGVPVLG FVITILNLQK SWAIVENHVI IQAEFYLSPD KSGEFMFDFD
60 70 80 90 100
GDEIFHVDME KRETVWRLEE FGHFASFEAQ GALANIAVDK ANLEILIKRS
110 120 130 140 150
NNTPNTNVPP EVTVLSDKPV ELGEPNILIC FIDKFSPPVV NVTWLRNGSP
160 170 180 190 200
VTRGVSETVF LPREDHLFRK FHYLPFMPST EDVYDCQVEH WGLDKPLLKH
210 220 230 240 250
WEFEAQTPLP ETTENTVCAL GLIVALVGII VGTVLIIKGV RKGNATERRG

PL
Length:252
Mass (Da):28,382
Last modified:November 1, 1996 - v1
Checksum:iF47D022AB8D44A82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93028 mRNA. Translation: AAA31075.1.
AY247783 mRNA. Translation: AAO63765.1.
AY285926 mRNA. Translation: AAP37550.1.
AY285935 mRNA. Translation: AAP37559.1.
AY285937 mRNA. Translation: AAP37561.1.
DQ883223 mRNA. Translation: ABI31830.1.
EF143987 mRNA. Translation: ABK96887.1.
EU722918 mRNA. Translation: ACE07020.1.
FJ905836 Genomic DNA. Translation: ADB82916.1.
PIRiA46505.
RefSeqiNP_001107178.1. NM_001113706.1.
UniGeneiSsc.222.

Genome annotation databases

GeneIDi100135040.
KEGGissc:100135040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M93028 mRNA. Translation: AAA31075.1.
AY247783 mRNA. Translation: AAO63765.1.
AY285926 mRNA. Translation: AAP37550.1.
AY285935 mRNA. Translation: AAP37559.1.
AY285937 mRNA. Translation: AAP37561.1.
DQ883223 mRNA. Translation: ABI31830.1.
EF143987 mRNA. Translation: ABK96887.1.
EU722918 mRNA. Translation: ACE07020.1.
FJ905836 Genomic DNA. Translation: ADB82916.1.
PIRiA46505.
RefSeqiNP_001107178.1. NM_001113706.1.
UniGeneiSsc.222.

3D structure databases

ProteinModelPortaliQ31065.
SMRiQ31065. Positions 26-205.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100135040.
KEGGissc:100135040.

Organism-specific databases

CTDi100135040.

Phylogenomic databases

HOVERGENiHBG006862.
KOiK06752.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and expression of class II alpha genes in miniature swine."
    Hirsch F., Germana S., Gustafsson K., Pratt K., Sachs D.H., Leguern C.
    J. Immunol. 149:841-846(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Minnesota miniature swineImported.
    Tissue: Spleen and bloodImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "Characterization and clone of Hunan Shaziling pig DR gene."
    Tang Y., Xing X., Wang W.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: EarImported.
  4. "Sequence-based characterization of the eight SLA loci in Korean native pigs."
    Lee Y.J., Cho K.H., Kim M.J., Smith D.M., Ho C.S., Jung K.C., Jin D.I., Park C.S., Jeon J.T., Lee J.H.
    Int. J. Immunogenet. 35:333-334(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "Sequence base SLA typing in CMS miniature pig."
    Yeom S.C., Park C.G., Lee B.C., Lee W.J.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. "cDNA cloning, genomic structure and genetic polymorphism of swine MHC class I and II genes in Chinese mini pig."
    Mo S., Jing Z., Fang Y., Feng H.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ31065_PIG
AccessioniPrimary (citable) accession number: Q31065
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: February 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.