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Q31065

- Q31065_PIG

UniProt

Q31065 - Q31065_PIG

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Protein
Submitted name: MHC class II DR-alpha
Gene
SLA-DR-alpha, SLA-DRA, SLA-DRA1
Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II DR-alphaImported
Submitted name:
MHC class II antigenImported
Submitted name:
MHC class II antigen DR-alphaImported
Gene namesi
Name:SLA-DR-alphaImported
Synonyms:SLA-DRAImported, SLA-DRA1Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

GO - Cellular componenti

  1. MHC class II protein complex Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotations

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 PredictedImported
Add
BLAST
Chaini23 – 252230MHC class II DR-alphaImported
PRO_5000143831Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliQ31065.
SMRiQ31065. Positions 26-205.

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotations

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG006862.
KOiK06752.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q31065-1 [UniParc]FASTAAdd to Basket

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MTILGVPVLG FVITILNLQK SWAIVENHVI IQAEFYLSPD KSGEFMFDFD    50
GDEIFHVDME KRETVWRLEE FGHFASFEAQ GALANIAVDK ANLEILIKRS 100
NNTPNTNVPP EVTVLSDKPV ELGEPNILIC FIDKFSPPVV NVTWLRNGSP 150
VTRGVSETVF LPREDHLFRK FHYLPFMPST EDVYDCQVEH WGLDKPLLKH 200
WEFEAQTPLP ETTENTVCAL GLIVALVGII VGTVLIIKGV RKGNATERRG 250
PL 252
Length:252
Mass (Da):28,382
Last modified:November 1, 1996 - v1
Checksum:iF47D022AB8D44A82
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M93028 mRNA. Translation: AAA31075.1.
AY247783 mRNA. Translation: AAO63765.1.
AY285926 mRNA. Translation: AAP37550.1.
AY285935 mRNA. Translation: AAP37559.1.
AY285937 mRNA. Translation: AAP37561.1.
DQ883223 mRNA. Translation: ABI31830.1.
EF143987 mRNA. Translation: ABK96887.1.
EU722918 mRNA. Translation: ACE07020.1.
FJ905836 Genomic DNA. Translation: ADB82916.1.
PIRiA46505.
RefSeqiNP_001107178.1. NM_001113706.1.
UniGeneiSsc.222.

Genome annotation databases

GeneIDi100135040.
KEGGissc:100135040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M93028 mRNA. Translation: AAA31075.1 .
AY247783 mRNA. Translation: AAO63765.1 .
AY285926 mRNA. Translation: AAP37550.1 .
AY285935 mRNA. Translation: AAP37559.1 .
AY285937 mRNA. Translation: AAP37561.1 .
DQ883223 mRNA. Translation: ABI31830.1 .
EF143987 mRNA. Translation: ABK96887.1 .
EU722918 mRNA. Translation: ACE07020.1 .
FJ905836 Genomic DNA. Translation: ADB82916.1 .
PIRi A46505.
RefSeqi NP_001107178.1. NM_001113706.1.
UniGenei Ssc.222.

3D structure databases

ProteinModelPortali Q31065.
SMRi Q31065. Positions 26-205.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100135040.
KEGGi ssc:100135040.

Organism-specific databases

CTDi 100135040.

Phylogenomic databases

HOVERGENi HBG006862.
KOi K06752.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of class II alpha genes in miniature swine."
    Hirsch F., Germana S., Gustafsson K., Pratt K., Sachs D.H., Leguern C.
    J. Immunol. 149:841-846(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Minnesota miniature swineImported.
    Tissue: Spleen and bloodImported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
  3. "Characterization and clone of Hunan Shaziling pig DR gene."
    Tang Y., Xing X., Wang W.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: EarImported.
  4. "Sequence-based characterization of the eight SLA loci in Korean native pigs."
    Lee Y.J., Cho K.H., Kim M.J., Smith D.M., Ho C.S., Jung K.C., Jin D.I., Park C.S., Jeon J.T., Lee J.H.
    Int. J. Immunogenet. 35:333-334(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "Sequence base SLA typing in CMS miniature pig."
    Yeom S.C., Park C.G., Lee B.C., Lee W.J.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. "cDNA cloning, genomic structure and genetic polymorphism of swine MHC class I and II genes in Chinese mini pig."
    Mo S., Jing Z., Fang Y., Feng H.
    Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ31065_PIG
AccessioniPrimary (citable) accession number: Q31065
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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