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Q31065

- Q31065_PIG

UniProt

Q31065 - Q31065_PIG

Protein
Submitted name:

MHC class II DR-alpha

Gene

SLA-DR-alpha

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
    2. immune response Source: InterPro

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MHC class II DR-alphaImported
    Submitted name:
    MHC class II antigenImported
    Submitted name:
    MHC class II antigen DR-alphaImported
    Gene namesi
    Name:SLA-DR-alphaImported
    Synonyms:SLA-DRAImported, SLA-DRA1Imported
    OrganismiSus scrofa (Pig)Imported
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. MHC class II protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, MHC IISAAS annotation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222 PotentialImportedAdd
    BLAST
    Chaini23 – 252230MHC class II DR-alphaImportedPRO_5000143831Add
    BLAST

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ31065.
    SMRiQ31065. Positions 26-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MHC class II family.UniRule annotation
    Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

    Keywords - Domaini

    SignalImported, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG006862.
    KOiK06752.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR001003. MHC_II_a_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00993. MHC_II_alpha. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    SM00920. MHC_II_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q31065-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTILGVPVLG FVITILNLQK SWAIVENHVI IQAEFYLSPD KSGEFMFDFD    50
    GDEIFHVDME KRETVWRLEE FGHFASFEAQ GALANIAVDK ANLEILIKRS 100
    NNTPNTNVPP EVTVLSDKPV ELGEPNILIC FIDKFSPPVV NVTWLRNGSP 150
    VTRGVSETVF LPREDHLFRK FHYLPFMPST EDVYDCQVEH WGLDKPLLKH 200
    WEFEAQTPLP ETTENTVCAL GLIVALVGII VGTVLIIKGV RKGNATERRG 250
    PL 252
    Length:252
    Mass (Da):28,382
    Last modified:November 1, 1996 - v1
    Checksum:iF47D022AB8D44A82
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M93028 mRNA. Translation: AAA31075.1.
    AY247783 mRNA. Translation: AAO63765.1.
    AY285926 mRNA. Translation: AAP37550.1.
    AY285935 mRNA. Translation: AAP37559.1.
    AY285937 mRNA. Translation: AAP37561.1.
    DQ883223 mRNA. Translation: ABI31830.1.
    EF143987 mRNA. Translation: ABK96887.1.
    EU722918 mRNA. Translation: ACE07020.1.
    FJ905836 Genomic DNA. Translation: ADB82916.1.
    PIRiA46505.
    RefSeqiNP_001107178.1. NM_001113706.1.
    UniGeneiSsc.222.

    Genome annotation databases

    GeneIDi100135040.
    KEGGissc:100135040.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M93028 mRNA. Translation: AAA31075.1 .
    AY247783 mRNA. Translation: AAO63765.1 .
    AY285926 mRNA. Translation: AAP37550.1 .
    AY285935 mRNA. Translation: AAP37559.1 .
    AY285937 mRNA. Translation: AAP37561.1 .
    DQ883223 mRNA. Translation: ABI31830.1 .
    EF143987 mRNA. Translation: ABK96887.1 .
    EU722918 mRNA. Translation: ACE07020.1 .
    FJ905836 Genomic DNA. Translation: ADB82916.1 .
    PIRi A46505.
    RefSeqi NP_001107178.1. NM_001113706.1.
    UniGenei Ssc.222.

    3D structure databases

    ProteinModelPortali Q31065.
    SMRi Q31065. Positions 26-205.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100135040.
    KEGGi ssc:100135040.

    Organism-specific databases

    CTDi 100135040.

    Phylogenomic databases

    HOVERGENi HBG006862.
    KOi K06752.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR001003. MHC_II_a_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00993. MHC_II_alpha. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00920. MHC_II_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of class II alpha genes in miniature swine."
      Hirsch F., Germana S., Gustafsson K., Pratt K., Sachs D.H., Leguern C.
      J. Immunol. 149:841-846(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Minnesota miniature swineImported.
      Tissue: Spleen and bloodImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
    3. "Characterization and clone of Hunan Shaziling pig DR gene."
      Tang Y., Xing X., Wang W.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: EarImported.
    4. "Sequence-based characterization of the eight SLA loci in Korean native pigs."
      Lee Y.J., Cho K.H., Kim M.J., Smith D.M., Ho C.S., Jung K.C., Jin D.I., Park C.S., Jeon J.T., Lee J.H.
      Int. J. Immunogenet. 35:333-334(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    5. "Sequence base SLA typing in CMS miniature pig."
      Yeom S.C., Park C.G., Lee B.C., Lee W.J.
      Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    6. "cDNA cloning, genomic structure and genetic polymorphism of swine MHC class I and II genes in Chinese mini pig."
      Mo S., Jing Z., Fang Y., Feng H.
      Submitted (APR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ31065_PIG
    AccessioniPrimary (citable) accession number: Q31065
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)