ID   Q31064_PIG              Unreviewed;       253 AA.
AC   Q31064;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 112.
DE   SubName: Full=MHC class II DR-alpha {ECO:0000313|EMBL:AAA31074.1};
DE   Flags: Fragment;
GN   Name=SLA-DR-alpha {ECO:0000313|EMBL:AAA31074.1};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|EMBL:AAA31074.1};
RN   [1] {ECO:0000313|EMBL:AAA31074.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Minnesota miniature swine {ECO:0000313|EMBL:AAA31074.1};
RC   TISSUE=Spleen and blood {ECO:0000313|EMBL:AAA31074.1};
RX   PubMed=1634772;
RA   Hirsch F., Germana S., Gustafsson K., Pratt K., Sachs D.H., Leguern C.;
RT   "Structure and expression of class II alpha genes in miniature swine.";
RL   J. Immunol. 149:841-846(1992).
CC   -!- SIMILARITY: Belongs to the MHC class II family.
CC       {ECO:0000256|RuleBase:RU004238}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M92445; AAA31074.1; -; mRNA.
DR   AlphaFoldDB; Q31064; -.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR001003; MHC_II_a_N.
DR   PANTHER; PTHR19944:SF86; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00993; MHC_II_alpha; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00920; MHC_II_alpha; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   MHC II {ECO:0000256|ARBA:ARBA00023182};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        231..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          122..202
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAA31074.1"
FT   NON_TER         253
FT                   /evidence="ECO:0000313|EMBL:AAA31074.1"
SQ   SEQUENCE   253 AA;  28483 MW;  4B63811D5A88A167 CRC64;
     ALPTLIEASK EKMTILGVPV LGFVITILNL QKSWAIVENH VIIQAEFYLS PDKSGEFMFD
     FDGDEIFHVD MEKRETVWRL EEFGHFASFE AQGALANIAV DKANLEILIK RSNNTPNTNV
     PPEVTVLSDK PVELGEPNIL ICFIDKFSPP VVNVTWLRNG SPVTRGVSET VFLPREDHLF
     RKFHYLPFMP STEDVYDCQV EHWGLDKPLL KHWEFEAQTP LPETTENTVC ALGLIVALVG
     IIVGTVLIIK GVR
//