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Protein
Submitted name:

MHC class II DR-alpha

Gene

SLA-DR-alpha

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II DR-alphaImported
Gene namesi
Name:SLA-DR-alphaImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 24›24 PotentialImportedAdd
BLAST
Chaini25 – ›253›229MHC class II DR-alphaImportedPRO_5000143669Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001567.

Structurei

3D structure databases

ProteinModelPortaliQ31064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOGENOMiHOG000112076.
HOVERGENiHBG006862.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q31064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ALPTLIEASK EKMTILGVPV LGFVITILNL QKSWAIVENH VIIQAEFYLS
60 70 80 90 100
PDKSGEFMFD FDGDEIFHVD MEKRETVWRL EEFGHFASFE AQGALANIAV
110 120 130 140 150
DKANLEILIK RSNNTPNTNV PPEVTVLSDK PVELGEPNIL ICFIDKFSPP
160 170 180 190 200
VVNVTWLRNG SPVTRGVSET VFLPREDHLF RKFHYLPFMP STEDVYDCQV
210 220 230 240 250
EHWGLDKPLL KHWEFEAQTP LPETTENTVC ALGLIVALVG IIVGTVLIIK

GVR
Length:253
Mass (Da):28,483
Last modified:November 1, 1996 - v1
Checksum:i4B63811D5A88A167
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei253 – 2531Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92445 mRNA. Translation: AAA31074.1.
UniGeneiSsc.222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92445 mRNA. Translation: AAA31074.1.
UniGeneiSsc.222.

3D structure databases

ProteinModelPortaliQ31064.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000001567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOGENOMiHOG000112076.
HOVERGENiHBG006862.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structure and expression of class II alpha genes in miniature swine."
    Hirsch F., Germana S., Gustafsson K., Pratt K., Sachs D.H., Leguern C.
    J. Immunol. 149:841-846(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Minnesota miniature swineImported.
    Tissue: Spleen and bloodImported.

Entry informationi

Entry nameiQ31064_PIG
AccessioniPrimary (citable) accession number: Q31064
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.