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Q31064

- Q31064_PIG

UniProt

Q31064 - Q31064_PIG

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Protein
Submitted name:

MHC class II DR-alpha

Gene

SLA-DR-alpha

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II DR-alphaImported
Gene namesi
Name:SLA-DR-alphaImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. MHC class II protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 24›24 PotentialImportedAdd
BLAST
Chaini25 – ›253›229MHC class II DR-alphaImportedPRO_5000143669Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ31064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOGENOMiHOG000112076.
HOVERGENiHBG006862.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q31064-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
ALPTLIEASK EKMTILGVPV LGFVITILNL QKSWAIVENH VIIQAEFYLS
60 70 80 90 100
PDKSGEFMFD FDGDEIFHVD MEKRETVWRL EEFGHFASFE AQGALANIAV
110 120 130 140 150
DKANLEILIK RSNNTPNTNV PPEVTVLSDK PVELGEPNIL ICFIDKFSPP
160 170 180 190 200
VVNVTWLRNG SPVTRGVSET VFLPREDHLF RKFHYLPFMP STEDVYDCQV
210 220 230 240 250
EHWGLDKPLL KHWEFEAQTP LPETTENTVC ALGLIVALVG IIVGTVLIIK

GVR
Length:253
Mass (Da):28,483
Last modified:November 1, 1996 - v1
Checksum:i4B63811D5A88A167
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei253 – 2531Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92445 mRNA. Translation: AAA31074.1.
UniGeneiSsc.222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M92445 mRNA. Translation: AAA31074.1 .
UniGenei Ssc.222.

3D structure databases

ProteinModelPortali Q31064.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000112076.
HOVERGENi HBG006862.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and expression of class II alpha genes in miniature swine."
    Hirsch F., Germana S., Gustafsson K., Pratt K., Sachs D.H., Leguern C.
    J. Immunol. 149:841-846(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Minnesota miniature swineImported.
    Tissue: Spleen and bloodImported.

Entry informationi

Entry nameiQ31064_PIG
AccessioniPrimary (citable) accession number: Q31064
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)