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Q30ZX9

- DAPAT_DESAG

UniProt

Q30ZX9 - DAPAT_DESAG

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Protein

LL-diaminopimelate aminotransferase

Gene
dapL, Dde_1970
Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli By similarity.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411Substrate; via amide nitrogen By similarity
Binding sitei67 – 671Pyridoxal phosphate; shared with dimeric partner By similarity
Binding sitei129 – 1291Substrate By similarity
Binding sitei179 – 1791Pyridoxal phosphate By similarity
Binding sitei179 – 1791Substrate By similarity
Binding sitei207 – 2071Pyridoxal phosphate By similarity
Binding sitei210 – 2101Pyridoxal phosphate By similarity
Binding sitei239 – 2391Pyridoxal phosphate By similarity
Binding sitei241 – 2411Pyridoxal phosphate By similarity
Binding sitei250 – 2501Pyridoxal phosphate By similarity
Binding sitei368 – 3681Substrate By similarity

GO - Molecular functioni

  1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciDALA207559:GH1L-1750-MONOMER.
UniPathwayiUPA00034; UER00466.

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferase (EC:2.6.1.83)
Short name:
DAP-AT
Short name:
DAP-aminotransferase
Short name:
LL-DAP-aminotransferase
Gene namesi
Name:dapL
Ordered Locus Names:Dde_1970
OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Taxonomic identifieri207559 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002710: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388LL-diaminopimelate aminotransferaseUniRule annotationPRO_0000342235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei242 – 2421N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi207559.Dde_1970.

Structurei

3D structure databases

ProteinModelPortaliQ30ZX9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000223051.
KOiK10206.
OMAiINISCKV.
OrthoDBiEOG6W721W.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1.
InterProiIPR004839. Aminotransferase_I/II.
IPR019881. DAP-NH2Trfase_DapL_Desulfo.
IPR019942. DapL_aminotrans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03540. DapC_direct. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q30ZX9-1 [UniParc]FASTAAdd to Basket

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MTQFTLADRL ATLPPYLFAQ IDKVKAEVAA RGVDIISLGI GDPDMPTPDF    50
VIEALKKAAE KPANHQYPSY TGMLAFRQEV ANWYKRRYAV ELDPKTEVLT 100
LIGSKEGIAH FPTAFVNPGD LVLVCPPCYP VYAIASRFMG GVVQELPLLE 150
ENDFLPDLDA VDEATWEKAR CIFVNYPNNP TAAMAPRSFF EKLIGIARKH 200
NVIVVHDAAY TEMYYNENNR PLSIMEIPGA MDVAIEFNSL SKPYNMTGWR 250
IAMAVGNASL VAGLGKVKEN MDSGAFQAVQ EAAIVALRDG DAFLAEIRDI 300
YRKRRDTVIA ALNKIGITCR VPEASLYVWA RVPEGYTSSD FVTRVLQETG 350
VVMTPGNGFG AAGEGYFRIS LTVNDERLEE AVSRIASL 388
Length:388
Mass (Da):42,773
Last modified:December 6, 2005 - v1
Checksum:i68CA2F7BA4A6942C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000112 Genomic DNA. Translation: ABB38767.1.
RefSeqiWP_011367877.1. NC_007519.1.
YP_388462.1. NC_007519.1.

Genome annotation databases

EnsemblBacteriaiABB38767; ABB38767; Dde_1970.
GeneIDi3756976.
KEGGidde:Dde_1970.
PATRICi21742873. VBIDesDes50040_1949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000112 Genomic DNA. Translation: ABB38767.1 .
RefSeqi WP_011367877.1. NC_007519.1.
YP_388462.1. NC_007519.1.

3D structure databases

ProteinModelPortali Q30ZX9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 207559.Dde_1970.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB38767 ; ABB38767 ; Dde_1970 .
GeneIDi 3756976.
KEGGi dde:Dde_1970.
PATRICi 21742873. VBIDesDes50040_1949.

Phylogenomic databases

eggNOGi COG0436.
HOGENOMi HOG000223051.
KOi K10206.
OMAi INISCKV.
OrthoDBi EOG6W721W.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00466 .
BioCyci DALA207559:GH1L-1750-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01642. DapL_aminotrans_1.
InterProi IPR004839. Aminotransferase_I/II.
IPR019881. DAP-NH2Trfase_DapL_Desulfo.
IPR019942. DapL_aminotrans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR03540. DapC_direct. 1 hit.
PROSITEi PS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G20.

Entry informationi

Entry nameiDAPAT_DESAG
AccessioniPrimary (citable) accession number: Q30ZX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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