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Q30ZX9

- DAPAT_DESAG

UniProt

Q30ZX9 - DAPAT_DESAG

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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei41 – 411Substrate; via amide nitrogenUniRule annotation
Binding sitei67 – 671Pyridoxal phosphate; shared with dimeric partnerUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation
Binding sitei179 – 1791Pyridoxal phosphateUniRule annotation
Binding sitei179 – 1791SubstrateUniRule annotation
Binding sitei207 – 2071Pyridoxal phosphateUniRule annotation
Binding sitei210 – 2101Pyridoxal phosphateUniRule annotation
Binding sitei239 – 2391Pyridoxal phosphateUniRule annotation
Binding sitei241 – 2411Pyridoxal phosphateUniRule annotation
Binding sitei250 – 2501Pyridoxal phosphateUniRule annotation
Binding sitei368 – 3681SubstrateUniRule annotation

GO - Molecular functioni

  1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciDALA207559:GH1L-1750-MONOMER.
UniPathwayiUPA00034; UER00466.

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:Dde_1970
OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Taxonomic identifieri207559 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002710: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388LL-diaminopimelate aminotransferasePRO_0000342235Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei242 – 2421N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi207559.Dde_1970.

Structurei

3D structure databases

ProteinModelPortaliQ30ZX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0436.
HOGENOMiHOG000223051.
KOiK10206.
OMAiINISCKV.
OrthoDBiEOG6W721W.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01642. DapL_aminotrans_1.
InterProiIPR004839. Aminotransferase_I/II.
IPR019881. DAP-NH2Trfase_DapL_Desulfo.
IPR019942. DapL_aminotrans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR03540. DapC_direct. 1 hit.
PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q30ZX9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQFTLADRL ATLPPYLFAQ IDKVKAEVAA RGVDIISLGI GDPDMPTPDF
60 70 80 90 100
VIEALKKAAE KPANHQYPSY TGMLAFRQEV ANWYKRRYAV ELDPKTEVLT
110 120 130 140 150
LIGSKEGIAH FPTAFVNPGD LVLVCPPCYP VYAIASRFMG GVVQELPLLE
160 170 180 190 200
ENDFLPDLDA VDEATWEKAR CIFVNYPNNP TAAMAPRSFF EKLIGIARKH
210 220 230 240 250
NVIVVHDAAY TEMYYNENNR PLSIMEIPGA MDVAIEFNSL SKPYNMTGWR
260 270 280 290 300
IAMAVGNASL VAGLGKVKEN MDSGAFQAVQ EAAIVALRDG DAFLAEIRDI
310 320 330 340 350
YRKRRDTVIA ALNKIGITCR VPEASLYVWA RVPEGYTSSD FVTRVLQETG
360 370 380
VVMTPGNGFG AAGEGYFRIS LTVNDERLEE AVSRIASL
Length:388
Mass (Da):42,773
Last modified:December 6, 2005 - v1
Checksum:i68CA2F7BA4A6942C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000112 Genomic DNA. Translation: ABB38767.1.
RefSeqiYP_388462.1. NC_007519.1.

Genome annotation databases

EnsemblBacteriaiABB38767; ABB38767; Dde_1970.
GeneIDi3756976.
KEGGidde:Dde_1970.
PATRICi21742873. VBIDesDes50040_1949.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000112 Genomic DNA. Translation: ABB38767.1 .
RefSeqi YP_388462.1. NC_007519.1.

3D structure databases

ProteinModelPortali Q30ZX9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 207559.Dde_1970.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB38767 ; ABB38767 ; Dde_1970 .
GeneIDi 3756976.
KEGGi dde:Dde_1970.
PATRICi 21742873. VBIDesDes50040_1949.

Phylogenomic databases

eggNOGi COG0436.
HOGENOMi HOG000223051.
KOi K10206.
OMAi INISCKV.
OrthoDBi EOG6W721W.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00466 .
BioCyci DALA207559:GH1L-1750-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01642. DapL_aminotrans_1.
InterProi IPR004839. Aminotransferase_I/II.
IPR019881. DAP-NH2Trfase_DapL_Desulfo.
IPR019942. DapL_aminotrans.
IPR004838. NHTrfase_class1_PyrdxlP-BS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR03540. DapC_direct. 1 hit.
PROSITEi PS00105. AA_TRANSFER_CLASS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G20.

Entry informationi

Entry nameiDAPAT_DESAG
AccessioniPrimary (citable) accession number: Q30ZX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3