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Q30ZX9

- DAPAT_DESAG

UniProt

Q30ZX9 - DAPAT_DESAG

Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli.UniRule annotation

    Catalytic activityi

    LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411Substrate; via amide nitrogenUniRule annotation
    Binding sitei67 – 671Pyridoxal phosphate; shared with dimeric partnerUniRule annotation
    Binding sitei129 – 1291SubstrateUniRule annotation
    Binding sitei179 – 1791Pyridoxal phosphateUniRule annotation
    Binding sitei179 – 1791SubstrateUniRule annotation
    Binding sitei207 – 2071Pyridoxal phosphateUniRule annotation
    Binding sitei210 – 2101Pyridoxal phosphateUniRule annotation
    Binding sitei239 – 2391Pyridoxal phosphateUniRule annotation
    Binding sitei241 – 2411Pyridoxal phosphateUniRule annotation
    Binding sitei250 – 2501Pyridoxal phosphateUniRule annotation
    Binding sitei368 – 3681SubstrateUniRule annotation

    GO - Molecular functioni

    1. L,L-diaminopimelate aminotransferase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciDALA207559:GH1L-1750-MONOMER.
    UniPathwayiUPA00034; UER00466.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
    Short name:
    DAP-ATUniRule annotation
    Short name:
    DAP-aminotransferaseUniRule annotation
    Short name:
    LL-DAP-aminotransferaseUniRule annotation
    Gene namesi
    Name:dapLUniRule annotation
    Ordered Locus Names:Dde_1970
    OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
    Taxonomic identifieri207559 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000002710: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 388388LL-diaminopimelate aminotransferasePRO_0000342235Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei242 – 2421N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi207559.Dde_1970.

    Structurei

    3D structure databases

    ProteinModelPortaliQ30ZX9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0436.
    HOGENOMiHOG000223051.
    KOiK10206.
    OMAiINISCKV.
    OrthoDBiEOG6W721W.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPiMF_01642. DapL_aminotrans_1.
    InterProiIPR004839. Aminotransferase_I/II.
    IPR019881. DAP-NH2Trfase_DapL_Desulfo.
    IPR019942. DapL_aminotrans.
    IPR004838. NHTrfase_class1_PyrdxlP-BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR03540. DapC_direct. 1 hit.
    PROSITEiPS00105. AA_TRANSFER_CLASS_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q30ZX9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQFTLADRL ATLPPYLFAQ IDKVKAEVAA RGVDIISLGI GDPDMPTPDF    50
    VIEALKKAAE KPANHQYPSY TGMLAFRQEV ANWYKRRYAV ELDPKTEVLT 100
    LIGSKEGIAH FPTAFVNPGD LVLVCPPCYP VYAIASRFMG GVVQELPLLE 150
    ENDFLPDLDA VDEATWEKAR CIFVNYPNNP TAAMAPRSFF EKLIGIARKH 200
    NVIVVHDAAY TEMYYNENNR PLSIMEIPGA MDVAIEFNSL SKPYNMTGWR 250
    IAMAVGNASL VAGLGKVKEN MDSGAFQAVQ EAAIVALRDG DAFLAEIRDI 300
    YRKRRDTVIA ALNKIGITCR VPEASLYVWA RVPEGYTSSD FVTRVLQETG 350
    VVMTPGNGFG AAGEGYFRIS LTVNDERLEE AVSRIASL 388
    Length:388
    Mass (Da):42,773
    Last modified:December 6, 2005 - v1
    Checksum:i68CA2F7BA4A6942C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000112 Genomic DNA. Translation: ABB38767.1.
    RefSeqiWP_011367877.1. NC_007519.1.
    YP_388462.1. NC_007519.1.

    Genome annotation databases

    EnsemblBacteriaiABB38767; ABB38767; Dde_1970.
    GeneIDi3756976.
    KEGGidde:Dde_1970.
    PATRICi21742873. VBIDesDes50040_1949.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000112 Genomic DNA. Translation: ABB38767.1 .
    RefSeqi WP_011367877.1. NC_007519.1.
    YP_388462.1. NC_007519.1.

    3D structure databases

    ProteinModelPortali Q30ZX9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 207559.Dde_1970.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB38767 ; ABB38767 ; Dde_1970 .
    GeneIDi 3756976.
    KEGGi dde:Dde_1970.
    PATRICi 21742873. VBIDesDes50040_1949.

    Phylogenomic databases

    eggNOGi COG0436.
    HOGENOMi HOG000223051.
    KOi K10206.
    OMAi INISCKV.
    OrthoDBi EOG6W721W.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00466 .
    BioCyci DALA207559:GH1L-1750-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    HAMAPi MF_01642. DapL_aminotrans_1.
    InterProi IPR004839. Aminotransferase_I/II.
    IPR019881. DAP-NH2Trfase_DapL_Desulfo.
    IPR019942. DapL_aminotrans.
    IPR004838. NHTrfase_class1_PyrdxlP-BS.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR03540. DapC_direct. 1 hit.
    PROSITEi PS00105. AA_TRANSFER_CLASS_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G20.

    Entry informationi

    Entry nameiDAPAT_DESAG
    AccessioniPrimary (citable) accession number: Q30ZX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3