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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei584ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDALA207559:G1G52-2289-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Dde_2439
OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Taxonomic identifieri207559 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002710 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000093341 – 829Leucine--tRNA ligaseAdd BLAST829

Proteomic databases

PRIDEiQ30YL0

Interactioni

Protein-protein interaction databases

STRINGi207559.Dde_2439

Structurei

3D structure databases

ProteinModelPortaliQ30YL0
SMRiQ30YL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 50"HIGH" regionAdd BLAST11
Motifi581 – 585"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 2 hits
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q30YL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYNPQAIEE KWQHIWEEKE MFRSEHGSDK PKYYVLEMFP YPSGNIHMGH
60 70 80 90 100
VRNYSIGDVV ARFKRMQGFN VLHPMGWDAF GLPAENAAIK HDTHPAKWTY
110 120 130 140 150
SNIDNMRSQL KRLGYSYDWR RELATCDAEY YRWEQLFFLK FMEKGLIYRK
160 170 180 190 200
KAPQNWCPKC NTVLANEQVI DGLCWRCDSV VEQRDLAQWF LRITSYAEEL
210 220 230 240 250
LADLEKLTGG WPDRVLTMQH NWIGKSVGAE IEFAVDGSDE TVKVFTTRPD
260 270 280 290 300
TVFGSTFMSI APEHPLVEKL ITGTGQEETV RAFVTRIRNM DRIERTADTL
310 320 330 340 350
EKEGVFTGAY CINPLSGRRM PIYVANFVLA EYGTGAVMAV PAHDERDFEF
360 370 380 390 400
ARKYDLPMEV VIQPEGAELT PATMETAYTG QGTMVGSGQF SGLPNEEGKT
410 420 430 440 450
KIAEWLEANG KGKRTVNYRL RDWNISRQRY WGAPIPVVYC EKCGIVPEKA
460 470 480 490 500
ENLPVRLPLD IKTRSDGRSP LGETPEFYEC RCPACGEKAR RETDTMDTFV
510 520 530 540 550
ESSWYFARYT SAGDNEAPFD AQALKYWLPV DQYIGGVEHA ILHLLYARFF
560 570 580 590 600
IKALRDCGYM DLDEPFANLL TQGMVLMDGA KMSKSKGNVV DPTEMISRYG
610 620 630 640 650
ADTVRLFCLF AAPPERDFDW SDSGIEGASR FVNRVWRLVE DLPAGMAPMA
660 670 680 690 700
PCSSSSDDCT GAAAKDIRQK EHATVKKAGA DIQNRFQFNT AISAVMELVN
710 720 730 740 750
ALYLTRDELG ADEKGRRVLG SAVSSVLAML APITPHLCEE LWEQLGHKDM
760 770 780 790 800
LTARPWPRYD EDALLRDEVV IPVSVNGKLR SKMTVPAGTG KEELEKLALA
810 820
EANVVRHTEG LTVRKVIVIP GKMVNVVAS
Length:829
Mass (Da):93,741
Last modified:December 6, 2005 - v1
Checksum:iAC87239C9C5C73C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000112 Genomic DNA Translation: ABB39236.1
RefSeqiWP_011368305.1, NC_007519.1

Genome annotation databases

EnsemblBacteriaiABB39236; ABB39236; Dde_2439
KEGGidde:Dde_2439

Similar proteinsi

Entry informationi

Entry nameiSYL_DESAG
AccessioniPrimary (citable) accession number: Q30YL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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