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Q30YL0

- SYL_DESAG

UniProt

Q30YL0 - SYL_DESAG

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Protein
Leucine--tRNA ligase
Gene
leuS, Dde_2439
Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDALA207559:GH1L-2190-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Dde_2439
OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Taxonomic identifieri207559 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002710: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Leucine--tRNA ligaseUniRule annotation
PRO_1000009334Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi207559.Dde_2439.

Structurei

3D structure databases

ProteinModelPortaliQ30YL0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionUniRule annotation
Add
BLAST
Motifi581 – 5855"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q30YL0-1 [UniParc]FASTAAdd to Basket

« Hide

MKYNPQAIEE KWQHIWEEKE MFRSEHGSDK PKYYVLEMFP YPSGNIHMGH    50
VRNYSIGDVV ARFKRMQGFN VLHPMGWDAF GLPAENAAIK HDTHPAKWTY 100
SNIDNMRSQL KRLGYSYDWR RELATCDAEY YRWEQLFFLK FMEKGLIYRK 150
KAPQNWCPKC NTVLANEQVI DGLCWRCDSV VEQRDLAQWF LRITSYAEEL 200
LADLEKLTGG WPDRVLTMQH NWIGKSVGAE IEFAVDGSDE TVKVFTTRPD 250
TVFGSTFMSI APEHPLVEKL ITGTGQEETV RAFVTRIRNM DRIERTADTL 300
EKEGVFTGAY CINPLSGRRM PIYVANFVLA EYGTGAVMAV PAHDERDFEF 350
ARKYDLPMEV VIQPEGAELT PATMETAYTG QGTMVGSGQF SGLPNEEGKT 400
KIAEWLEANG KGKRTVNYRL RDWNISRQRY WGAPIPVVYC EKCGIVPEKA 450
ENLPVRLPLD IKTRSDGRSP LGETPEFYEC RCPACGEKAR RETDTMDTFV 500
ESSWYFARYT SAGDNEAPFD AQALKYWLPV DQYIGGVEHA ILHLLYARFF 550
IKALRDCGYM DLDEPFANLL TQGMVLMDGA KMSKSKGNVV DPTEMISRYG 600
ADTVRLFCLF AAPPERDFDW SDSGIEGASR FVNRVWRLVE DLPAGMAPMA 650
PCSSSSDDCT GAAAKDIRQK EHATVKKAGA DIQNRFQFNT AISAVMELVN 700
ALYLTRDELG ADEKGRRVLG SAVSSVLAML APITPHLCEE LWEQLGHKDM 750
LTARPWPRYD EDALLRDEVV IPVSVNGKLR SKMTVPAGTG KEELEKLALA 800
EANVVRHTEG LTVRKVIVIP GKMVNVVAS 829
Length:829
Mass (Da):93,741
Last modified:December 6, 2005 - v1
Checksum:iAC87239C9C5C73C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000112 Genomic DNA. Translation: ABB39236.1.
RefSeqiWP_011368305.1. NC_007519.1.
YP_388931.1. NC_007519.1.

Genome annotation databases

EnsemblBacteriaiABB39236; ABB39236; Dde_2439.
GeneIDi3757455.
KEGGidde:Dde_2439.
PATRICi21743821. VBIDesDes50040_2413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000112 Genomic DNA. Translation: ABB39236.1 .
RefSeqi WP_011368305.1. NC_007519.1.
YP_388931.1. NC_007519.1.

3D structure databases

ProteinModelPortali Q30YL0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 207559.Dde_2439.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB39236 ; ABB39236 ; Dde_2439 .
GeneIDi 3757455.
KEGGi dde:Dde_2439.
PATRICi 21743821. VBIDesDes50040_2413.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DALA207559:GH1L-2190-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G20.

Entry informationi

Entry nameiSYL_DESAG
AccessioniPrimary (citable) accession number: Q30YL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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