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Q30YL0

- SYL_DESAG

UniProt

Q30YL0 - SYL_DESAG

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei584 – 5841ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDALA207559:GH1L-2190-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Dde_2439
OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Taxonomic identifieri207559 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002710: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 829829Leucine--tRNA ligasePRO_1000009334Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi207559.Dde_2439.

Structurei

3D structure databases

ProteinModelPortaliQ30YL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5011"HIGH" regionAdd
BLAST
Motifi581 – 5855"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiVVHCDAC.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q30YL0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKYNPQAIEE KWQHIWEEKE MFRSEHGSDK PKYYVLEMFP YPSGNIHMGH
60 70 80 90 100
VRNYSIGDVV ARFKRMQGFN VLHPMGWDAF GLPAENAAIK HDTHPAKWTY
110 120 130 140 150
SNIDNMRSQL KRLGYSYDWR RELATCDAEY YRWEQLFFLK FMEKGLIYRK
160 170 180 190 200
KAPQNWCPKC NTVLANEQVI DGLCWRCDSV VEQRDLAQWF LRITSYAEEL
210 220 230 240 250
LADLEKLTGG WPDRVLTMQH NWIGKSVGAE IEFAVDGSDE TVKVFTTRPD
260 270 280 290 300
TVFGSTFMSI APEHPLVEKL ITGTGQEETV RAFVTRIRNM DRIERTADTL
310 320 330 340 350
EKEGVFTGAY CINPLSGRRM PIYVANFVLA EYGTGAVMAV PAHDERDFEF
360 370 380 390 400
ARKYDLPMEV VIQPEGAELT PATMETAYTG QGTMVGSGQF SGLPNEEGKT
410 420 430 440 450
KIAEWLEANG KGKRTVNYRL RDWNISRQRY WGAPIPVVYC EKCGIVPEKA
460 470 480 490 500
ENLPVRLPLD IKTRSDGRSP LGETPEFYEC RCPACGEKAR RETDTMDTFV
510 520 530 540 550
ESSWYFARYT SAGDNEAPFD AQALKYWLPV DQYIGGVEHA ILHLLYARFF
560 570 580 590 600
IKALRDCGYM DLDEPFANLL TQGMVLMDGA KMSKSKGNVV DPTEMISRYG
610 620 630 640 650
ADTVRLFCLF AAPPERDFDW SDSGIEGASR FVNRVWRLVE DLPAGMAPMA
660 670 680 690 700
PCSSSSDDCT GAAAKDIRQK EHATVKKAGA DIQNRFQFNT AISAVMELVN
710 720 730 740 750
ALYLTRDELG ADEKGRRVLG SAVSSVLAML APITPHLCEE LWEQLGHKDM
760 770 780 790 800
LTARPWPRYD EDALLRDEVV IPVSVNGKLR SKMTVPAGTG KEELEKLALA
810 820
EANVVRHTEG LTVRKVIVIP GKMVNVVAS
Length:829
Mass (Da):93,741
Last modified:December 6, 2005 - v1
Checksum:iAC87239C9C5C73C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000112 Genomic DNA. Translation: ABB39236.1.
RefSeqiYP_388931.1. NC_007519.1.

Genome annotation databases

EnsemblBacteriaiABB39236; ABB39236; Dde_2439.
GeneIDi3757455.
KEGGidde:Dde_2439.
PATRICi21743821. VBIDesDes50040_2413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000112 Genomic DNA. Translation: ABB39236.1 .
RefSeqi YP_388931.1. NC_007519.1.

3D structure databases

ProteinModelPortali Q30YL0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 207559.Dde_2439.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB39236 ; ABB39236 ; Dde_2439 .
GeneIDi 3757455.
KEGGi dde:Dde_2439.
PATRICi 21743821. VBIDesDes50040_2413.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi VVHCDAC.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci DALA207559:GH1L-2190-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: G20.

Entry informationi

Entry nameiSYL_DESAG
AccessioniPrimary (citable) accession number: Q30YL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3