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Q30YB8

- ASSY_DESAG

UniProt

Q30YB8 - ASSY_DESAG

Protein

Argininosuccinate synthase

Gene

argG

Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei89 – 891CitrullineUniRule annotation
    Binding sitei94 – 941CitrullineUniRule annotation
    Binding sitei119 – 1191ATP; via amide nitrogenUniRule annotation
    Binding sitei121 – 1211AspartateUniRule annotation
    Binding sitei125 – 1251AspartateUniRule annotation
    Binding sitei125 – 1251CitrullineUniRule annotation
    Binding sitei126 – 1261AspartateUniRule annotation
    Binding sitei129 – 1291CitrullineUniRule annotation
    Binding sitei179 – 1791CitrullineUniRule annotation
    Binding sitei188 – 1881CitrullineUniRule annotation
    Binding sitei264 – 2641CitrullineUniRule annotation
    Binding sitei276 – 2761CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 199ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciDALA207559:GH1L-2267-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:Dde_2531
    OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
    Taxonomic identifieri207559 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000002710: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400Argininosuccinate synthasePRO_0000263922Add
    BLAST

    Proteomic databases

    PRIDEiQ30YB8.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi207559.Dde_2531.

    Structurei

    3D structure databases

    ProteinModelPortaliQ30YB8.
    SMRiQ30YB8. Positions 7-394.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiGIKSKFD.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q30YB8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKEIKKVVL AYSGGLDTSV ILKWIAKTYD CEVVTLTADL GQEEDLDGVD    50
    EKALRTGATR AYVEDLREEF ARDFIFPMMR ACAIYEGRYL LGTSIARPLI 100
    TRRLVEIAHA EGAQAVAHGA TGKGNDQVRF ELASAALDPS LKVIAPWREW 150
    DFRSRTDLLN FAAENDIPVI SAGNRKLYSM DRNMLHCSFE GGELEDPWNE 200
    PGPGSYIMAV PVEQAPDEPE YITIDFEKGN AVAINGQAMS PAAIIKTLNT 250
    LGGKHGVGRL DMVENRFVGM KSRGVYETPG GTVLHAAHRD LEGICLDREA 300
    LHLRDSLIPR YAAAVYNGFW YSPEREALQA LVDKTQENVT GTVRVKLYKG 350
    NVVPVGRKSP YSLYRMDLAT FEEDEVYNQA DAAGFIRLNS LRIQGYGRRS 400
    Length:400
    Mass (Da):44,358
    Last modified:December 6, 2005 - v1
    Checksum:iE8F528358DACF83E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000112 Genomic DNA. Translation: ABB39328.1.
    RefSeqiWP_011368380.1. NC_007519.1.
    YP_389023.1. NC_007519.1.

    Genome annotation databases

    EnsemblBacteriaiABB39328; ABB39328; Dde_2531.
    GeneIDi3757548.
    KEGGidde:Dde_2531.
    PATRICi21743999. VBIDesDes50040_2501.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000112 Genomic DNA. Translation: ABB39328.1 .
    RefSeqi WP_011368380.1. NC_007519.1.
    YP_389023.1. NC_007519.1.

    3D structure databases

    ProteinModelPortali Q30YB8.
    SMRi Q30YB8. Positions 7-394.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 207559.Dde_2531.

    Proteomic databases

    PRIDEi Q30YB8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB39328 ; ABB39328 ; Dde_2531 .
    GeneIDi 3757548.
    KEGGi dde:Dde_2531.
    PATRICi 21743999. VBIDesDes50040_2501.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi GIKSKFD.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci DALA207559:GH1L-2267-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: G20.

    Entry informationi

    Entry nameiASSY_DESAG
    AccessioniPrimary (citable) accession number: Q30YB8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3