Q30XT1 (KGUA_DESDG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	Dde_2719

Organism

Desulfovibrio desulfuricans (strain G20) [Complete proteome] [HAMAP]

Taxonomic identifier

207559 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › Desulfovibrio alaskensis

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Guanylate kinase HAMAP-Rule MF_00328		PRO_0000266318
Regions
	Domain	7 – 185	179	Guanylate kinase-like
	Nucleotide binding	14 – 21	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q30XT1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 6DA521CABD8CF894	FASTA	206	23,732
	10 20 30 40 50 60 MVRPRSGIVL VLCAPSGTGK TTLTRRLLEE FPRFAFSVSY TTRQPRAGEE HGREYNFVDE 70 80 90 100 110 120 ETFIRLRDEG FFAEWAEVHG NFYGTPLEDT RQLLARGRDV LFDIDVQGAA QLRGSLKQGC 130 140 150 160 170 180 YVFILPPSGA ELERRLRARG TDPEDTIRRR LANARRELQQ AHWFNAWIVN DNLEQAYDEL 190 200 RAAYLAATLS PTCRPELVDE LLQDWR

References

[1]

"Complete genome sequence and updated annotation of Desulfovibrio alaskensis G20." Hauser L.J., Land M.L., Brown S.D., Larimer F., Keller K.L., Rapp-Giles B.J., Price M.N., Lin M., Bruce D.C., Detter J.C., Tapia R., Han C.S., Goodwin L.A., Cheng J.F., Pitluck S., Copeland A., Lucas S., Nolan M. , Lapidus A.L., Palumbo A.V., Wall J.D. J. Bacteriol. 193:4268-4269(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G20.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000112 Genomic DNA. Translation: ABB39515.1.
RefSeq	YP_389210.1. NC_007519.1.
3D structure databases
HSSP	HSSP built from PDB template 2ANB based on UniProtKB P60546.
ProteinModelPortal	Q30XT1.
ModBase	Search...
Protein-protein interaction databases
STRING	207559.Dde_2719.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB39515; ABB39515; Dde_2719.
GeneID	3757742.
KEGG	dde:Dde_2719.
PATRIC	21744381. VBIDesDes50040_2686.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HOG000037640.
KO	K00942.
OMA	EWAEFAG.
ProtClustDB	CLSK704923.
Enzyme and pathway databases
BioCyc	DALA207559:GH1L-2434-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase.
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_DESDG

Accession

Primary (citable) accession number: Q30XT1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program