Q30WH2 (GSA_DESDG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase
Short name=GSA
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT

Gene names

Name:	hemL
Ordered Locus Names:	Dde_3180

Organism

Desulfovibrio desulfuricans (strain G20) [Complete proteome] [HAMAP]

Taxonomic identifier

207559 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › delta/epsilon subdivisions › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio › Desulfovibrio alaskensis

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375		PRO_0000243569
Amino acid modifications
	Modified residue	265	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q30WH2 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: F2C630E9A1C186CE	FASTA	422	45,013
	10 20 30 40 50 60 MERSRNLFER AQKLIPGGVN SPVRACLSVD SAPVFVERGQ GSKLYSVDGR EYIDFVESWG 70 80 90 100 110 120 PLLLGHAHPA VNKAIHEAVD KGSSFGAPCE DEIRLAEAVV DAVPSIEMVR MVSSGTEATM 130 140 150 160 170 180 SALRLARGYT GRNKLIKFEG CYHGHGDAFL ASAGSGVATL SIPGTPGVPD TVVADTLLAP 190 200 210 220 230 240 YNNLERVKAL FENHGADIAA VIVEPTAGNM GLVRPAAGFL QGLRELCDRY GALLIFDEVI 250 260 270 280 290 300 TGFRLSYGGA QQYFGITPDL TTLGKIIGGG MPVGAYGGRR EIMERIAPCG DVYQAGTLAG 310 320 330 340 350 360 NPVAMAAGIA TLAELKKADY PALEKRVDAL ASEIEAILKA KGVPVTVNRL ASMFTIFFTE 370 380 390 400 410 420 EPVTDYDSAK KADGTLYTRF YQQMRDQGIY LAPSGFECAM VSLAHTEDDF AAMLAAVRNV TF

References

[1]

"Complete genome sequence and updated annotation of Desulfovibrio alaskensis G20." Hauser L.J., Land M.L., Brown S.D., Larimer F., Keller K.L., Rapp-Giles B.J., Price M.N., Lin M., Bruce D.C., Detter J.C., Tapia R., Han C.S., Goodwin L.A., Cheng J.F., Pitluck S., Copeland A., Lucas S., Nolan M. , Lapidus A.L., Palumbo A.V., Wall J.D. J. Bacteriol. 193:4268-4269(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: G20.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000112 Genomic DNA. Translation: ABB39974.1.
RefSeq	YP_389669.1. NC_007519.1.
3D structure databases
ProteinModelPortal	Q30WH2.
SMR	Q30WH2. Positions 3-420.
ModBase	Search...
Protein-protein interaction databases
STRING	207559.Dde_3180.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB39974; ABB39974; Dde_3180.
GeneID	3758155.
KEGG	dde:Dde_3180.
PATRIC	21745255. VBIDesDes50040_3112.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	NANIPFF.
ProtClustDB	PRK00062.
Enzyme and pathway databases
BioCyc	DALA207559:GH1L-2838-MONOMER.
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA_DESDG

Accession

Primary (citable) accession number: Q30WH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program