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Protein

Acetate kinase

Gene

ackA

Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.UniRule annotation

Catalytic activityi

ATP + acetate = ADP + acetyl phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Mg2+. Can also accept Mn2+.UniRule annotation

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes acetyl-CoA from acetate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (Dde_3241)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Binding sitei14ATPUniRule annotation1
Binding sitei95SubstrateUniRule annotation1
Active sitei152Proton donor/acceptorUniRule annotation1
Sitei184Transition state stabilizerUniRule annotation1
Sitei245Transition state stabilizerUniRule annotation1
Metal bindingi388MagnesiumUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi212 – 216ATPUniRule annotation5
Nucleotide bindingi286 – 288ATPUniRule annotation3
Nucleotide bindingi334 – 338ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDALA207559:G1G52-3039-MONOMER.
UniPathwayiUPA00340; UER00458.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetate kinaseUniRule annotation (EC:2.7.2.1UniRule annotation)
Alternative name(s):
AcetokinaseUniRule annotation
Gene namesi
Name:ackAUniRule annotation
Ordered Locus Names:Dde_3242
OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Taxonomic identifieri207559 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002710 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000022281 – 402Acetate kinaseAdd BLAST402

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi207559.Dde_3242.

Structurei

3D structure databases

ProteinModelPortaliQ30WB0.
SMRiQ30WB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetokinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6H. Bacteria.
COG0282. LUCA.
HOGENOMiHOG000288398.
KOiK00925.
OMAiWKALTGT.
OrthoDBiPOG091H02K4.

Family and domain databases

HAMAPiMF_00020. Acetate_kinase. 1 hit.
InterProiView protein in InterPro
IPR004372. Ac/propionate_kinase.
IPR000890. Aliphatic_acid_kin_short-chain.
IPR023865. Aliphatic_acid_kinase_CS.
PANTHERiPTHR21060. PTHR21060. 1 hit.
PfamiView protein in Pfam
PF00871. Acetate_kinase. 1 hit.
PIRSFiPIRSF000722. Acetate_prop_kin. 1 hit.
PRINTSiPR00471. ACETATEKNASE.
TIGRFAMsiTIGR00016. ackA. 1 hit.
PROSITEiView protein in PROSITE
PS01075. ACETATE_KINASE_1. 1 hit.
PS01076. ACETATE_KINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q30WB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVLVINAGS SSCKYQLINM ESEGVLCAGL VERIGEATGK LAHKIAPDTD
60 70 80 90 100
SEEKIVLEQP FPNHVEAMKK VVELITDPEK GVIKDKSEIY AIGHRVLLGG
110 120 130 140 150
EEIKESVKID EWAKGVIRDY IPLGPLHNPA NLAGIEVAEE LFPGVPSVGV
160 170 180 190 200
FDTEFHQTMP AKAYLYPLPL ELYEEMKIRR YGFHGTSHRY VTKKTAEFLG
210 220 230 240 250
KPLDEVNIIT CHLGNGCSMA AVKNGKCVDT TMGITPLEGL MMGTRCGDID
260 270 280 290 300
PAIVPFLMEK KGLTTAEADT LMNKQSGLKG VCGMNDMRDI HAAVEKGDEK
310 320 330 340 350
AKLALDMFVY RIKKYIGAFY AALGRVDAVV FTAGIGENDD IVRAEVCENM
360 370 380 390 400
DVFGIALDAE KNKIRSGEPR NIAAENSKVA VLVVPTNEEL EIAQAAVNVL

KG
Length:402
Mass (Da):43,764
Last modified:December 6, 2005 - v1
Checksum:iBF771F55F3A39868
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000112 Genomic DNA. Translation: ABB40036.1.
RefSeqiWP_011368985.1. NC_007519.1.

Genome annotation databases

EnsemblBacteriaiABB40036; ABB40036; Dde_3242.
KEGGidde:Dde_3242.

Similar proteinsi

Entry informationi

Entry nameiACKA_DESAG
AccessioniPrimary (citable) accession number: Q30WB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: February 28, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome