Reviewed, UniProtKB/Swiss-Prot Q30VD9 (AROE_DESDG)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	Dde_3564

Organism

Desulfovibrio desulfuricans (strain G20) [Complete proteome] [HAMAP]

Taxonomic identifier

207559 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Deltaproteobacteria › Desulfovibrionales › Desulfovibrionaceae › Desulfovibrio

Protein attributes

Sequence length	279 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 279	279	Shikimate dehydrogenase HAMAP MF_00222		PRO_1000021280
Regions
	Nucleotide binding	130 – 134	5	NADP By similarity
Sites
	Active site	72	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q30VD9-1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 4C577295A27B3491	FASTA	279	29,799
	10 20 30 40 50 60 MTIPRIPRQL YGIIGYPLGH SMSPLLHNWG FELLGEQAAY MAFPVAPEKL AEFICCARML 70 80 90 100 110 120 PVSGLSVTIP HKQAVMPLLD AVTPRAQAAG AVNTLFYDDG KLTGDNTDVY GFLHPLDSCG 130 140 150 160 170 180 TAHAAALVLG AGGAANAVLA ALTARGMCNV TVTNRNGDRA RILAERFGVR CVAWEERHAV 190 200 210 220 230 240 DADLVVNTTP LGMAGDRQAQ TPLDPAFFSS RPAGLAYDLI YNPAQTFFLA SAQAAGWRVL 250 260 270 NGLDMFVAQG AEQFRIWRGR ELPFAQARAL IADALASGC

References

[1]

"Complete sequence of Desulfovibrio desulfuricans G20." Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goodwin L.A., Schmutz J., Larimer F., Land M., Kyrpides N., Ivanova N., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000112 Genomic DNA. Translation: ABB40357.1.
RefSeq	YP_390052.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3758544.
GenomeReviews	Gene locus Dde_3564 in contig CP000112_GR.
KEGG	dde:Dde_3564.
NMPDR	fig|207559.3.peg.2396.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q30VD9.
OMA	Q30VD9. YRAHEVT.
Enzyme and pathway databases
BioCyc	DDES207559:DDE_3564-MON.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_DESDG

Accession

Primary (citable) accession number: Q30VD9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 6, 2005
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)