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Q30UH8

- UPPP_SULDN

UniProt

Q30UH8 - UPPP_SULDN

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, Suden_0072
Organism
Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciSDEN326298:GH9P-77-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:Suden_0072
OrganismiSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Taxonomic identifieri326298 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
ProteomesiUP000002714: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed predictionAdd
BLAST
Transmembranei39 – 5921Helical; Reviewed predictionAdd
BLAST
Transmembranei70 – 9021Helical; Reviewed predictionAdd
BLAST
Transmembranei97 – 11721Helical; Reviewed predictionAdd
BLAST
Transmembranei134 – 15421Helical; Reviewed predictionAdd
BLAST
Transmembranei176 – 19621Helical; Reviewed predictionAdd
BLAST
Transmembranei205 – 22521Helical; Reviewed predictionAdd
BLAST
Transmembranei235 – 25521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Undecaprenyl-diphosphataseUniRule annotationPRO_0000227646Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326298.Suden_0072.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q30UH8-1 [UniParc]FASTAAdd to Basket

« Hide

MTILDSIILG AIEGFTEFLP ISSTGHLIVA SEFLGLEQNA INKAYEVIIQ    50
FSAILAVIFN YKDKFSIKKI DLWMKVFIAF LPLAIIGFIF STQIKELFSL 100
HVVAVMFIVG GVVFLIVEKF FINEDEKTIY EVEAISLKQS LIIGFAQIFA 150
LIPGTSRAGS TIIGALLVGL SRKASAEFSF LLAFPVMGAV TAYDLLKHYK 200
DFSEANLIIL GVGFVTSFVV AYLSIKLFLK FLEKFTFFFF GVYRIVFGVI 250
LLLFFN 256
Length:256
Mass (Da):28,561
Last modified:December 6, 2005 - v1
Checksum:i14E4BD25E973F12F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000153 Genomic DNA. Translation: ABB43353.1.
RefSeqiYP_392588.1. NC_007575.1.

Genome annotation databases

EnsemblBacteriaiABB43353; ABB43353; Suden_0072.
GeneIDi3763210.
KEGGitdn:Suden_0072.
PATRICi23768604. VBISulDen68967_0075.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000153 Genomic DNA. Translation: ABB43353.1 .
RefSeqi YP_392588.1. NC_007575.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326298.Suden_0072.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB43353 ; ABB43353 ; Suden_0072 .
GeneIDi 3763210.
KEGGi tdn:Suden_0072.
PATRICi 23768604. VBISulDen68967_0075.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci SDEN326298:GH9P-77-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33889 / DSM 1251.

Entry informationi

Entry nameiUPPP_SULDN
AccessioniPrimary (citable) accession number: Q30UH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi