Q30TL4 (OTC_SULDN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ornithine carbamoyltransferase
Short name=OTCase
EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	Suden_0386

Organism

Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251)) [Complete proteome] [HAMAP]

Taxonomic identifier

326298 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Sulfurimonas

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm By similarity HAMAP MF_01109.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_1000163990
Regions
	Region	55 – 59	5	Carbamoyl phosphate binding By similarity
	Region	266 – 269	4	Ornithine binding By similarity
Sites
	Binding site	106	1	Carbamoyl phosphate By similarity
	Binding site	133	1	Carbamoyl phosphate By similarity
	Site	30	1	Important for structural integrity By similarity
	Site	146	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q30TL4 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: ADA7AF79404E046A	FASTA	312	35,301
	10 20 30 40 50 60 MGKLLRHFLT LRDFSKDEIL EIINIGLEIK KSLKSAVCKH ELKNQTLAMI FEKSSTRTRV 70 80 90 100 110 120 SFETGMFQLG GHALFLSNRD IHLGRGEPVK DTARVISGMC DMIMIRTFEH SRIEEFASYS 130 140 150 160 170 180 KVPVINGLTD SYHPVQLLAD YMTLVEYGME KNIIAAYVGD GNNMTHSWMM LAAKLGFELR 190 200 210 220 230 240 VATPKGYEVD EKILQEALLI AKESGAVIKV TNDPSEAVKG ATVVTTDTWT SMGQEEEKEA 250 260 270 280 290 300 RIRIFNGFMV DEKMMSQAAS NAKFLHCLPA YRGLEVSEEV FEKHSEIIFN EAENRLHAQK 310 GLMVWLDKQR NI

References

[1]

"Genome of the epsilonproteobacterial chemolithoautotroph Sulfurimonas denitrificans." Sievert S.M., Scott K.M., Klotz M.G., Chain P.S.G., Hauser L.J., Hemp J., Huegler M., Land M., Lapidus A., Larimer F.W., Lucas S., Malfatti S.A., Meyer F., Paulsen I.T., Ren Q., Simon J., Bailey K., Diaz E. , Fitzpatrick K.A., Glover B., Gwatney N., Korajkic A., Long A., Mobberley J.M., Pantry S.N., Pazder G., Peterson S., Quintanilla J.D., Sprinkle R., Stephens J., Thomas P., Vaughn R., Weber M.J., Wooten L.L. Appl. Environ. Microbiol. 74:1145-1156(2008) [PubMed: 18065616] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 33889 / DSM 1251.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000153 Genomic DNA. Translation: ABB43667.1.
RefSeq	YP_392902.1. NC_007575.1.
3D structure databases
HSSP	HSSP built from PDB template 1VLV based on UniProtKB P96108.
ProteinModelPortal	Q30TL4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q30TL4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3764115.
GenomeReviews	Gene locus Suden_0386 in contig CP000153_GR.
KEGG	tdn:Suden_0386.
NMPDR	fig|326298.3.peg.1482.
PATRIC	23769280. VBISulDen68967_0403.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0078.
HOGENOM	HBG579429.
OMA	GVDCVVT.
ProtClustDB	PRK00779.
Enzyme and pathway databases
BioCyc	TDEN326298:TMDEN_0386-MONOMER.
Family and domain databases
HAMAP	MF_01109. OTCase. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002292. Orn/put_carbamltrans. IPR024904. Orn_carbamltrans. [Graphical view]
KO	K00611.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00658. Orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_SULDN

Accession

Primary (citable) accession number: Q30TL4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	December 6, 2005
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program