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Q30TH2

- PNP_SULDN

UniProt

Q30TH2 - PNP_SULDN

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

    Catalytic activityi

    RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi511 – 5111MagnesiumUniRule annotation
    Metal bindingi517 – 5171MagnesiumUniRule annotation

    GO - Molecular functioni

    1. 3'-5'-exoribonuclease activity Source: InterPro
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
    4. RNA binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. mRNA catabolic process Source: UniProtKB-HAMAP
    2. RNA processing Source: InterPro

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciSDEN326298:GH9P-444-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
    Alternative name(s):
    Polynucleotide phosphorylaseUniRule annotation
    Short name:
    PNPaseUniRule annotation
    Gene namesi
    Name:pnpUniRule annotation
    Ordered Locus Names:Suden_0428
    OrganismiSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
    Taxonomic identifieri326298 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
    ProteomesiUP000002714: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 721721Polyribonucleotide nucleotidyltransferasePRO_0000329891Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326298.Suden_0428.

    Structurei

    3D structure databases

    ProteinModelPortaliQ30TH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini577 – 63761KHUniRule annotationAdd
    BLAST
    Domaini654 – 72168S1 motifUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
    Contains 1 KH domain.UniRule annotation
    Contains 1 S1 motif domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1185.
    HOGENOMiHOG000218326.
    KOiK00962.
    OMAiPRWDWVA.
    OrthoDBiEOG6WT8CC.

    Family and domain databases

    Gene3Di1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPiMF_01595. PNPase.
    InterProiIPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PANTHERiPTHR11252. PTHR11252. 1 hit.
    PfamiPF13014. KH_3. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005499. PNPase. 1 hit.
    SMARTiSM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view]
    SUPFAMiSSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    PROSITEiPS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q30TH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKYDIKIDLK NKNEEYSFGE VAKQANGAAW LKSGNTVILA TVVIDETEIV    50
    KDDFLPLTVQ YIEKAYAAGK IPGGFFKRET KASDFETLTS RIVDRSLRPL 100
    FPKGFGHPTQ ITIMVFSVDK ESDLQVLALN AASAALYVSD IDINKSVSAI 150
    RVAKIDGELI LNPTLSELDK STLDLYLSGT KEDLLMIEMR SKGGIKVDTN 200
    LMIDPLMDPT LSSAIIATHV SNAVPEDELI TILAKAEELL FETNAMYEEM 250
    FKEFKKETSP LECKAHALNE EMLKYVRSNH YSDIKSAMNQ MAKSERSTAL 300
    RQLRKKIIIT KEEWDEVELK DVIESVKKEQ VRGQILNDRV RADGRALNEI 350
    RPISISTNVL PSAHASCLFT RGQTQALVVL TMGGPKDAQM FENLTDEGTQ 400
    NENFMVHYNF PGFSVGEASP IMGTKRRELG HGNLAKRALE PIVNLEGQTV 450
    RLVSEILESN GSSSMATVCG GYMALRAADI ETSDTIAGIA MGMVSEGDKY 500
    AILSDIMGLE DHDGDLDFKV TGSKDGITAM QMDIKLGGIS LNILKEALYQ 550
    AKEGRAHIIN IMQEAEKNIS FNDGVLPSTD FFHINPSFIG DIIGQAGKTI 600
    REIIEKFEVA IDIDKKDGKV KVTGKSKSGV QAAREHIEGI VSTPKMPKIE 650
    YKVGDIHKGI VKKIVEFGAF IELPDGVDGL LHISKISDQR VEKVSDILKE 700
    GEEINVEILE FKGNKISLGI A 721
    Length:721
    Mass (Da):79,428
    Last modified:December 6, 2005 - v1
    Checksum:iC76693166F5B8581
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000153 Genomic DNA. Translation: ABB43709.1.
    RefSeqiWP_011372063.1. NC_007575.1.
    YP_392944.1. NC_007575.1.

    Genome annotation databases

    EnsemblBacteriaiABB43709; ABB43709; Suden_0428.
    GeneIDi3764561.
    KEGGitdn:Suden_0428.
    PATRICi23769366. VBISulDen68967_0446.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000153 Genomic DNA. Translation: ABB43709.1 .
    RefSeqi WP_011372063.1. NC_007575.1.
    YP_392944.1. NC_007575.1.

    3D structure databases

    ProteinModelPortali Q30TH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326298.Suden_0428.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB43709 ; ABB43709 ; Suden_0428 .
    GeneIDi 3764561.
    KEGGi tdn:Suden_0428.
    PATRICi 23769366. VBISulDen68967_0446.

    Phylogenomic databases

    eggNOGi COG1185.
    HOGENOMi HOG000218326.
    KOi K00962.
    OMAi PRWDWVA.
    OrthoDBi EOG6WT8CC.

    Enzyme and pathway databases

    BioCyci SDEN326298:GH9P-444-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.400. 1 hit.
    2.40.50.140. 1 hit.
    3.30.1370.10. 1 hit.
    3.30.230.70. 2 hits.
    HAMAPi MF_01595. PNPase.
    InterProi IPR001247. ExoRNase_PH_dom1.
    IPR015847. ExoRNase_PH_dom2.
    IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    IPR012340. NA-bd_OB-fold.
    IPR012162. PNPase.
    IPR027408. PNPase/RNase_PH_dom.
    IPR015848. PNPase_PH_RNA-bd_bac/org-type.
    IPR003029. Rbsml_prot_S1_RNA-bd_dom.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    PANTHERi PTHR11252. PTHR11252. 1 hit.
    Pfami PF13014. KH_3. 1 hit.
    PF03726. PNPase. 1 hit.
    PF01138. RNase_PH. 2 hits.
    PF03725. RNase_PH_C. 2 hits.
    PF00575. S1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005499. PNPase. 1 hit.
    SMARTi SM00322. KH. 1 hit.
    SM00316. S1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46915. SSF46915. 1 hit.
    SSF50249. SSF50249. 1 hit.
    SSF54211. SSF54211. 2 hits.
    SSF54791. SSF54791. 1 hit.
    SSF55666. SSF55666. 2 hits.
    PROSITEi PS50084. KH_TYPE_1. 1 hit.
    PS50126. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33889 / DSM 1251.

    Entry informationi

    Entry nameiPNP_SULDN
    AccessioniPrimary (citable) accession number: Q30TH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3