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Q30TC5 (DXS_SULDN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7
Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS
Gene names
Name:dxs
Ordered Locus Names:Suden_0475
OrganismSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251)) [Complete proteome] [HAMAP]
Taxonomic identifier326298 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Sulfurimonas

Protein attributes

Sequence length606 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315

Catalytic activity

Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315

Cofactor

Binds 1 thiamine pyrophosphate per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315

Subunit structure

Homodimer By similarity. HAMAP MF_00315

Sequence similarities

Belongs to the transketolase family. DXPS subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 6066061-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315
PRO_0000256500

Sequences

Sequence LengthMass (Da)Tools
Q30TC5 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 40923339C7685B22

FASTA60667,048
        10         20         30         40         50         60 
MNIKASRIKE LETLCKNIRE EILRVVSKNG GHLSSTLGAT EIIVAMHEVF DSKKDPFIFD 

        70         80         90        100        110        120 
VSHQSYAHKL LTGRWDKFDT LREFNGLCGY TKPSESEHDY FVAGHSSTSI SLGVGAAKAI 

       130        140        150        160        170        180 
ALKGEQNSRI PVIMIGDGSM TAGMVYEALN ELGERKYPMV IILNDNEMSI SKPIGAISRI 

       190        200        210        220        230        240 
LSSAMASPFY QNFKKHTENF VDNFGDGARY IAKRMEESLK LITPGIMFEE MGIDYIGPVD 

       250        260        270        280        290        300 
GHNIASLIEI LQKAKELKKP VIVHAQTLKG KGYEIAEGKD EKWHGVGPFD LDSGAASKKS 

       310        320        330        340        350        360 
SAKSATQIYA EALLHLAKNN DKIVGATAAM PSGTGLSELI ELYPNRFWDV AIAEQHAVTS 

       370        380        390        400        410        420 
MAALAKEGFK PFCTIYSTFL QRGYDQVIHD TCLMNLPVVF ALDRAGIVGE DGETHQGVFD 

       430        440        450        460        470        480 
VSFLRAIPNM TLFAPRDEKS FHQAMAFAAQ YQFPCSLRYP RGSFTQTSLP ESSPFELAKS 

       490        500        510        520        530        540 
QLLQSNKGDV LFIGYGNGVG RAYETSKLLE EKISILDLRF IKPLDKEMLR DMATKHNKWF 

       550        560        570        580        590        600 
IFSDSAKMGG VGSAILEFFA DEKILHVELE SFEYEDSFIT HGKTKDVEES LGLLPAQLAQ 


KVKALI

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000153 Genomic DNA. Translation: ABB43756.1.
RefSeqYP_392991.1. NC_007575.1.

3D structure databases

ProteinModelPortalQ30TC5.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ30TC5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3764597.
GenomeReviewsGene locus Suden_0475 in contig CP000153_GR.
KEGGtdn:Suden_0475.
NMPDRfig|326298.3.peg.1665.
PATRIC23769468. VBISulDen68967_0493.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1154.
HOGENOMHBG571647.
OMAIMEYAYL.
ProtClustDBPRK05444.

Enzyme and pathway databases

BioCycTDEN326298:TMDEN_0475-MONOMER.

Family and domain databases

HAMAPMF_00315. DXP_synth.
[Tree]
InterProIPR005477. Dxylulose-5-P_synthase.
IPR011766. TPP_enzyme-bd_C.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005475. Transketolase-like_Pyr-bd.
IPR020826. Transketolase_BS.
IPR005476. Transketolase_C.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK01662.
PfamPF02775. TPP_enzyme_C. 1 hit.
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00204. Dxs. 1 hit.
PROSITEPS00801. TRANSKETOLASE_1. False negative.
PS00802. TRANSKETOLASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDXS_SULDN
AccessionPrimary (citable) accession number: Q30TC5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 6, 2005
Last modified: January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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