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Q30TA4

- HISX_SULDN

UniProt

Q30TA4 - HISX_SULDN

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Protein

Histidinol dehydrogenase

Gene
hisD, Suden_0497
Organism
Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei237 – 2371Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Active sitei327 – 3271Proton acceptor By similarity
Active sitei328 – 3281Proton acceptor By similarity
Binding sitei328 – 3281Substrate By similarity
Metal bindingi361 – 3611Zinc By similarity
Binding sitei361 – 3611Substrate By similarity
Binding sitei415 – 4151Substrate By similarity
Metal bindingi420 – 4201Zinc By similarity
Binding sitei420 – 4201Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciSDEN326298:GH9P-518-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:Suden_0497
OrganismiSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Taxonomic identifieri326298 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
ProteomesiUP000002714: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Histidinol dehydrogenaseUniRule annotationPRO_0000229868Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326298.Suden_0497.

Structurei

3D structure databases

ProteinModelPortaliQ30TA4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q30TA4-1 [UniParc]FASTAAdd to Basket

« Hide

MIFTTSKNSS FKAEFKELLE RGKMDIAHVS ATVGTIIDEI KSNKNQALKE    50
HITKFDKWTP VSDEDLKIST ESMSRAYENL DKALKAALHL SYDRIKAYHE 100
KQKPRSWFDD EPNGTILGQR VTPVDSAGLY IPGGKAAYPS SLLMNVIPAQ 150
VAGVQNIVVC TPTPENEPNE LLLAACHLCG VSEVYKVGGA SAIAAMAYGT 200
ETIPKVDVIT GPGNIFVATA KKMVFGDVNI DMIAGPSEIG ILADDSANPS 250
HMAVDMLSQA EHDEMASSIL ITPSQKLADA IKAEIENWLK ILPRQKIARE 300
SIEKRGAIIV TSDMQEAIDL MNEIAPEHLE VATLSPFELL PLIKHAGAIF 350
LGHNTPEAVG DYMAGPNHTL PTGGTAKFFS PLGVENFMKK TSIISFSAKA 400
INEIGEECAL IAKIEGLTAH EQSIRVRLVK 430
Length:430
Mass (Da):46,589
Last modified:December 6, 2005 - v1
Checksum:i5670B1F26F3B3506
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000153 Genomic DNA. Translation: ABB43777.1.
RefSeqiYP_393012.1. NC_007575.1.

Genome annotation databases

EnsemblBacteriaiABB43777; ABB43777; Suden_0497.
GeneIDi3764580.
KEGGitdn:Suden_0497.
PATRICi23769516. VBISulDen68967_0517.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000153 Genomic DNA. Translation: ABB43777.1 .
RefSeqi YP_393012.1. NC_007575.1.

3D structure databases

ProteinModelPortali Q30TA4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326298.Suden_0497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB43777 ; ABB43777 ; Suden_0497 .
GeneIDi 3764580.
KEGGi tdn:Suden_0497.
PATRICi 23769516. VBISulDen68967_0517.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci SDEN326298:GH9P-518-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33889 / DSM 1251.

Entry informationi

Entry nameiHISX_SULDN
AccessioniPrimary (citable) accession number: Q30TA4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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