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Q30SS6 (IF2_SULDN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Translation initiation factor IF-2
Gene names
Name:infB
Ordered Locus Names:Suden_0676
OrganismSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251)) [Complete proteome] [HAMAP]
Taxonomic identifier326298 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Sulfurimonas ›

Protein attributes

Sequence length874 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex By similarity. HAMAP-Rule MF_00100

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the IF-2 family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionInitiation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processGTP catabolic process

Inferred from electronic annotation. Source: GOC

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GTPase activity

Inferred from electronic annotation. Source: HAMAP

translation initiation factor activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 874874Translation initiation factor IF-2 HAMAP-Rule MF_00100
PRO_0000335513

Regions

Nucleotide binding383 – 3908GTP By similarity
Nucleotide binding429 – 4335GTP By similarity
Nucleotide binding483 – 4864GTP By similarity
Region377 – 525149G-domain HAMAP-Rule MF_00100

Sequences

Sequence LengthMass (Da)Tools
Q30SS6 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 6B19F540A06F3905

FASTA87495,935
        10         20         30         40         50         60 
MTEKVRVHEI AKELGITSKD VVKKASDMGI EIKSANSSVS MEEAEGLMNY IMSGELAQSP 

        70         80         90        100        110        120 
TAEQKVQTKA PSHTPKEEDP TQESNKSQTT LSKKASETPI QHVVEKAKEI DVKNSEKEVI 

       130        140        150        160        170        180 
SEVKEIKKEE ESIESSELKK MQIKKSGLKI VKKKQPREEE KIQDDFISSV KQTQASISSY 

       190        200        210        220        230        240 
GKISAEVLEE LANKKKAKQA SSGAKKQEQG VKIDIFGASL SEVSMDMDDQ IVLLDLNSTQ 

       250        260        270        280        290        300 
RQELIAEEPR KPKVVKPAGR NANKKSAPKG RNVSRDKRKK YAKDKPEDLI VTHVEIPEDI 

       310        320        330        340        350        360 
RVYEFAEKLN RPISDVIKVL FSLGLMMTKN DFLGSDEIEI LSEEFGVEVT IVDPKDAFNY 

       370        380        390        400        410        420 
EEDLAEVIDE NATERPPVIT IMGHVDHGKT SLLDAIRKAK VTQDEAGGIT QHIGAYTIEQ 

       430        440        450        460        470        480 
NGKAITFLDT PGHAAFSQMR QRGTDVTDII IIVVAADDGV KPQTEEVIKL AKESKVPVIV 

       490        500        510        520        530        540 
AVNKMDKPTA NPDMVKAQMA ERGLNPIDWG GDIEFIPISA KSGMGIDELL ENILLTAEVL 

       550        560        570        580        590        600 
ELKANENAMA KAAVVESSLE KGRGPVATVI VQNGTLNVGD YVVCGSSYGR VKALINEHKQ 

       610        620        630        640        650        660 
QIKSIKPSHT AVVVGLNEVP SSGEIMMAMS SDKEAREYAL KRHEYDRHKE LSHSTKSTLE 

       670        680        690        700        710        720 
DMTSMIAEGR LKSLKVVLKT DVHGSLEAIR SSLNELRNDE VKINVISSGV GGITENDVEL 

       730        740        750        760        770        780 
VSNSENCVLL GFNVRPTGSV KALAKQKNVD IKTYSIIYQL LDDMTGMLMG MMAPKFSEIN 

       790        800        810        820        830        840 
TGQAEVRNTF KAPKGMVAGC VVVDGKLIRG GLVRVIRDGV VVHEGELTSL KRFKDDVDEI 

       850        860        870 
GNGYECGVMI KGYDDVIVGD VIETFKKVEQ KVSL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000153 Genomic DNA. Translation: ABB43955.1.
RefSeqYP_393190.1. NC_007575.1.

3D structure databases

HSSPHSSP built from PDB template 1D1N based on UniProtKB P04766.
ProteinModelPortalQ30SS6.
ModBaseSearch...

Protein-protein interaction databases

STRING326298.Suden_0676.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB43955; ABB43955; Suden_0676.
GeneID3764415.
KEGGtdn:Suden_0676.
PATRIC23769904. VBISulDen68967_0703.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0532.
HOGENOMHOG000076906.
KOK02519.
OMAQQGNRGY.
ProtClustDBPRK05306.

Enzyme and pathway databases

BioCycSDEN326298:GH9P-736-MONOMER.

Family and domain databases

Gene3D3.40.50.10050. 1 hit.
HAMAPMF_00100_B. IF-2_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR006847. IF2_N.
IPR005225. Small_GTP-bd_dom.
IPR000178. TF_IF2_bacterial-like.
IPR015760. TIF_IF2.
IPR023115. TIF_IF2_dom3.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR009000. Transl_elong_init/rib_B-barrel.
[Graphical view]
PANTHERPTHR23115:SF41. PTHR23115:SF41. 1 hit.
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 2 hits.
PF11987. IF-2. 1 hit.
PF04760. IF2_N. 2 hits.
[Graphical view]
SUPFAMSSF52156. TIF_IF2_dom3. 1 hit.
SSF50447. Translat_factor. 2 hits.
TIGRFAMsTIGR00487. IF-2. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS01176. IF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIF2_SULDN
AccessionPrimary (citable) accession number: Q30SS6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 6, 2005
Last modified: May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Translation initiation factors

List of translation initiation factor entries

SIMILARITY comments

Index of protein domains and families

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