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Q30S58 (PDXA_SULDN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
4-hydroxythreonine-4-phosphate dehydrogenase

EC=1.1.1.262
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene names
Name:pdxA
Ordered Locus Names:Suden_0895
OrganismSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251)) [Complete proteome] [HAMAP]
Taxonomic identifier326298 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity. HAMAP-Rule MF_00536

Catalytic activity

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH. HAMAP-Rule MF_00536

Cofactor

Binds 1 divalent metal cation per subunit. Can use ions such as zinc, magnesium or cobalt By similarity.

Pathway

Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5. HAMAP-Rule MF_00536

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00536

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00536.

Miscellaneous

The active site is located at the dimer interface By similarity.

Sequence similarities

Belongs to the PdxA family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3073074-hydroxythreonine-4-phosphate dehydrogenase HAMAP-Rule MF_00536
PRO_1000051524

Sites

Metal binding1501Divalent metal cation; shared with dimeric partner By similarity
Metal binding1891Divalent metal cation; shared with dimeric partner By similarity
Metal binding2451Divalent metal cation; shared with dimeric partner By similarity
Binding site1211Substrate By similarity
Binding site1221Substrate By similarity
Binding site2531Substrate By similarity
Binding site2621Substrate By similarity
Binding site2711Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q30S58 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: F4ED3F3E89C396FF

FASTA30734,239
        10         20         30         40         50         60 
MSKVRIAISV GDLNGVGIEI AIKAHEEVSK LCAPLYCINS YMLNQASTLL NYKIPSNFEI 

        70         80         90        100        110        120 
SEVGGEFAVK KGCVDKDSGR YSYDSFIHAI SLCEQKKADA VVTMPIHKEA WMLAGLKYKG 

       130        140        150        160        170        180 
HTDLLREHFK RDAIMMLGCQ KMFVALFSEH IPLKDVASSI KYKKLKQFFL DFNNSVPNER 

       190        200        210        220        230        240 
VAVLGLNPHA GDNGVLGNEE LIITKAIKSA NKKVCFEQFI GPLVPDIAFT PHIREKFKYF 

       250        260        270        280        290        300 
IAMYHDQGLA PLKALYFDES INVSLNLPII RTSVDHGTAF DIAYEKKAKT LSYINAIKSA 


IALGERL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000153 Genomic DNA. Translation: ABB44173.1.
RefSeqYP_393408.1. NC_007575.1.

3D structure databases

ProteinModelPortalQ30S58.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326298.Suden_0895.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB44173; ABB44173; Suden_0895.
GeneID3764108.
KEGGtdn:Suden_0895.
PATRIC23770368. VBISulDen68967_0925.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1995.
HOGENOMHOG000221591.
KOK00097.
OMAINCWEED.
OrthoDBEOG6GN6ZC.
ProtClustDBPRK03946.

Enzyme and pathway databases

BioCycSDEN326298:GH9P-936-MONOMER.
UniPathwayUPA00244; UER00312.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
HAMAPMF_00536. PdxA.
InterProIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00557. pdxA. 1 hit.
ProtoNetSearch...

Entry information

Entry namePDXA_SULDN
AccessionPrimary (citable) accession number: Q30S58
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways