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Q30S54 (Q30S54_SULDN) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172
Ordered Locus Names:Suden_0899
OrganismSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251)) [Complete proteome] [HAMAP]
Taxonomic identifier326298 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Sulfurimonas

Protein attributes

Sequence length759 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172 SAAS SAAS013215

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172 SAAS SAAS013215

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172 SAAS SAAS013215

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6441Zinc By similarity HAMAP MF_00172
Metal binding6461Zinc By similarity HAMAP MF_00172
Metal binding7291Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
Q30S54 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 39A4FDFCB623220A

FASTA75986,843
        10         20         30         40         50         60 
MSKNYIVGFP RIGEQRELKK VLEEFWAKKC SFEDVQTVAK ELKKRHWEYQ RDAGIEFISS 

        70         80         90        100        110        120 
NDFSLYDNML DTSVMLGAIP KKFKNLKNEE LYFAMARGNA SSVAMEMTKW FNTNYHYIVP 

       130        140        150        160        170        180 
ELEPSDSYKL DASKIVNEYN EAKSLGIKTK INIIGPITYL GLSKRADGGD TYELWGKIVP 

       190        200        210        220        230        240 
IYEELVKTIA TLDDEITIQI DEPIFVKEPN TKVLSLIKPT YDRLCAVSPN IKIAVVTYFE 

       250        260        270        280        290        300 
HSNEATKVLV HTPIWALGLD FLYGDENLNS LEIIASSGKK VIAGVVDGRN IWRCDIAKTI 

       310        320        330        340        350        360 
ALLQNISKIV KKENILLSSS CSLLHTPFTL KYEDKMDKDI KEWLSFALEK LSEISLISKI 

       370        380        390        400        410        420 
FFDGEGSINE REKEALINNE EANKSRKNSP LIHDRAVQER VQNHTKFQRD GISSERIALQ 

       430        440        450        460        470        480 
REIFGYKDLV TTTIGSFPQT PELRRTRSDF KNSLISRDEY EKEIKKYIDE CVLFQEECGL 

       490        500        510        520        530        540 
EVLVHGEPER NDMVEYFGEQ LSGYGFTQNG WVQSYGSRCV KPPFIYGDIS RPKPMTVDWT 

       550        560        570        580        590        600 
TYAQSKTERI MKGMLTGPVT ILNWSFVRDD MPRGEVSKQI AVALSDEIDD LQRAGIKIIQ 

       610        620        630        640        650        660 
VDEAAFKEGY PLRNEKIKIY EAWATRDFKI AVGSAKKETQ IHTHMCYSEF NDIINTIEDM 

       670        680        690        700        710        720 
DADVITIETA RSGNELLKIF KKVGYTKEVG PGVYDIHSPR IPSVEEIVSQ IELLLEVLPK 

       730        740        750 
EQLWINPDCG LKTRKWEEVK PSLKNMVEAV SIIRKKLSV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000153 Genomic DNA. Translation: ABB44177.1.
RefSeqYP_393412.1. NC_007575.1.

3D structure databases

ProteinModelPortalQ30S54.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ30S54.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3764073.
GenomeReviewsGene locus Suden_0899 in contig CP000153_GR.
KEGGtdn:Suden_0899.
NMPDRfig|326298.3.peg.1240.
PATRIC23770378. VBISulDen68967_0930.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0620.
HOGENOMHBG287495.
OMARNIWRAN.
ProtClustDBPRK05222.

Enzyme and pathway databases

BioCycTDEN326298:TMDEN_0899-MONOMER.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ30S54_SULDN
AccessionPrimary (citable) accession number: Q30S54
Entry history
Integrated into UniProtKB/TrEMBL: December 6, 2005
Last sequence update: December 6, 2005
Last modified: December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info