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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei171UniRule annotation1
Active sitei197UniRule annotation1
Active sitei293UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:Suden_0978
OrganismiSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Taxonomic identifieri326298 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
Proteomesi
  • UP000002714 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002643311 – 352Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei554-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi326298.Suden_0978.

Structurei

3D structure databases

ProteinModelPortaliQ30RX5.
SMRiQ30RX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 121Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini159 – 351CheB-type methylesteraseUniRule annotationAdd BLAST193

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiMLEMHRA.
OrthoDBiPOG091H045J.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q30RX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRVLIVDD SATARTVLKD VLSKDSEIEV IATAPDAYVA RDKIVQLKPD
60 70 80 90 100
VICLDVEMPR MDGISFLKKI MKYFPTPVLM VSSLTQDGAQ VTFDALEAGA
110 120 130 140 150
IDYVAKPHSN IYDGIDEIQK ELIQKVKMVA SSNLSARIEA AKAKTSTLEY
160 170 180 190 200
KPKATYSLAQ TTNKLIAIGA STGGTVALAE LIARFTKDTP GVVVVQHMPS
210 220 230 240 250
GFTNSFAQRL NSLCEVEVKE AEDGDIIGRG RVLVAPGDLH MVVRRDGGNY
260 270 280 290 300
RVKLGTGEKI SGHRPSVDVL FNSVASHVGS NAIGVLLTGM GSDGAKGMLK
310 320 330 340 350
MKTSGASTIA QDEKSSIVWG MPKVAYEIGA VDFVEPLSNI DVKIASLLSE

RK
Length:352
Mass (Da):37,684
Last modified:December 6, 2005 - v1
Checksum:i82513BCB526B6D1D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000153 Genomic DNA. Translation: ABB44256.1.

Genome annotation databases

EnsemblBacteriaiABB44256; ABB44256; Suden_0978.
KEGGitdn:Suden_0978.

Similar proteinsi

Entry informationi

Entry nameiCHEB_SULDN
AccessioniPrimary (citable) accession number: Q30RX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 6, 2005
Last modified: November 22, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome