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Protein
Submitted name:

Isocitrate dehydrogenase (NADP+)

Gene

Suden_1047

Organism
Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431SubstrateUniRule annotation
Sitei248 – 2481Critical for catalysisUniRule annotation
Metal bindingi341 – 3411Magnesium or manganeseUniRule annotation
Sitei411 – 4111Critical for catalysisUniRule annotation
Binding sitei537 – 5371SubstrateUniRule annotation
Metal bindingi538 – 5381Magnesium or manganeseUniRule annotation
Metal bindingi542 – 5421Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciSDEN326298:GH9P-1089-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase (NADP+)Imported (EC:1.1.1.42Imported)
Gene namesi
Ordered Locus Names:Suden_1047Imported
OrganismiSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))Imported
Taxonomic identifieri326298 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
ProteomesiUP000002714: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi326298.Suden_1047.

Structurei

3D structure databases

ProteinModelPortaliQ30RQ6.
SMRiQ30RQ6. Positions 2-729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate bindingUniRule annotation

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

Q30RQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKIIWSKID EAPALATYSL LPIVNAFTKA AGVEVVTSDI SLAGRVISKF
60 70 80 90 100
SDRLKPEQRI NDELAELGNV VLQPDGNIIK LPNISASVGQ LIECITELQA
110 120 130 140 150
QGYDVPNYPE DAKTDEEKAL KEIYSTCLGS AVNPVLREGN SDRRAAAAVK
160 170 180 190 200
RFAQKNPHKL RAFESPSKAY VAHMNGGDFF SNEKSVIVEG NAPVTIELNG
210 220 230 240 250
KVLKTLNDVV DKEIMDATFM SAKALQAFYQ KTLDDAKKNG VLWSLHLKAT
260 270 280 290 300
MMKVSDPIMF GHAVKVFFKD VFAKYGDELT AIGYNANMGL GDLYKKLEKS
310 320 330 340 350
SKKAEIIAAI EATYDIQPPM AMVDSDKGIT NLHASNDIII DASMPVVVRD
360 370 380 390 400
GGKMWNRDGK VQECVSVIPD ASYAFFHKAM VDDCVANGQY DVTTMGNVAN
410 420 430 440 450
VGLMAQKAEE YGSHPTTFEI AENGSVEVKQ NGKVLMSHNV EAGDIWRMSR
460 470 480 490 500
VKDIPIQDWV RLAVERARLT GSPAVFWLDK NRAHDANMIK KVNEYLKNHD
510 520 530 540 550
TTGLELPIMD VASAAKYTNA RVRKGEDTIS VTGNVLRDHL TDMYPILELG
560 570 580 590 600
TSAKMLSIVP LLAGGGVFET GAGGSAPKHV DQFLEEGHLR WDSLGEFLAL
610 620 630 640 650
AESLRFIAQK NSDDKLAAVT TALDIANAAY LDNNKAPSRK AGEPDNKASH
660 670 680 690 700
FFLAQYWAKA LSEGKNAELA AKFAPIAKAL TENEAKIIEE LLSIEGKAQD
710 720
IGGYYHPDDK KAEAAMRPSA TLNKIVDSI
Length:729
Mass (Da):79,562
Last modified:December 6, 2005 - v1
Checksum:iDEA21B28EE41B0D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000153 Genomic DNA. Translation: ABB44325.1.
RefSeqiYP_393560.1. NC_007575.1.

Genome annotation databases

EnsemblBacteriaiABB44325; ABB44325; Suden_1047.
GeneIDi3763931.
KEGGitdn:Suden_1047.
PATRICi23770696. VBISulDen68967_1088.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000153 Genomic DNA. Translation: ABB44325.1.
RefSeqiYP_393560.1. NC_007575.1.

3D structure databases

ProteinModelPortaliQ30RQ6.
SMRiQ30RQ6. Positions 2-729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi326298.Suden_1047.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB44325; ABB44325; Suden_1047.
GeneIDi3763931.
KEGGitdn:Suden_1047.
PATRICi23770696. VBISulDen68967_1088.

Phylogenomic databases

eggNOGiCOG2838.
HOGENOMiHOG000240860.
KOiK00031.
OMAiDENRAHD.
OrthoDBiEOG6DVJPP.

Enzyme and pathway databases

BioCyciSDEN326298:GH9P-1089-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33889 / DSM 1251Imported.

Entry informationi

Entry nameiQ30RQ6_SULDN
AccessioniPrimary (citable) accession number: Q30RQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.