Malate dehydrogenase - Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Malate dehydrogenase
EC=1.1.1.37

Gene names

Name:	mdh
Ordered Locus Names:	Suden_1048

Organism

Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251)) [Complete proteome] [HAMAP]

Taxonomic identifier

326298 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Sulfurimonas ›

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487
Catalytic activity	(S)-malate + NAD⁺ = oxaloacetate + NADH. HAMAP-Rule MF_00487
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro malate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular_function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 319

319

Malate dehydrogenase HAMAP-Rule MF_00487

PRO_0000241969

Regions

Nucleotide binding

11 – 16

6

NAD By similarity

Nucleotide binding

121 – 123

3

NAD By similarity

Sites

Active site

178

1

Proton acceptor By similarity

Binding site

36

1

NAD By similarity

Binding site

85

1

Substrate By similarity

Binding site

91

1

Substrate By similarity

Binding site

98

1

NAD By similarity

Binding site

123

1

Substrate By similarity

Binding site

154

1

Substrate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q30RQ5 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 880F5C01E08E221C
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FASTA

319

33,698

        10         20         30         40         50         60 
MNQGKRVGII GAGNVGATVA YSLAMLGSCH EIILRDNKID VAKGKALDMS QAAAAVRSHT 

        70         80         90        100        110        120 
IVSVAEEMAD LTNCDVVVVT AGSPRLPGMS RDDLLMINAN ITKDVIAGVA KYSPDAIIIM 

       130        140        150        160        170        180 
VSNPLDAMTY VALKESGFDR SRVIGMAGIL DSARMASFIQ EKLGYGGGQI RASVMGGHGD 

       190        200        210        220        230        240 
DMVPLARYST VAGVPLTDLM STSEINEIVI RTRNGGAEIV GHLKTGSAYY APAKATALMV 

       250        260        270        280        290        300 
EAILKDTKQI HPCAVFLEGE YGHSDVVSGV PVMLGANGAE KIIEISLDES EKIMFEGSCN 

       310 
SVRTLIDTLN KNKFFDKGE

« Hide

References

[1]

"Genome of the epsilonproteobacterial chemolithoautotroph Sulfurimonas denitrificans."
Sievert S.M., Scott K.M., Klotz M.G., Chain P.S.G., Hauser L.J., Hemp J., Huegler M., Land M., Lapidus A., Larimer F.W., Lucas S., Malfatti S.A., Meyer F., Paulsen I.T., Ren Q., Simon J., Bailey K., Diaz E.

Wooten L.L.
Appl. Environ. Microbiol. 74:1145-1156(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33889 / DSM 1251.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000153 Genomic DNA. Translation: ABB44326.1.
RefSeq	YP_393561.1. NC_007575.1.
3D structure databases
ProteinModelPortal	Q30RQ5.
ModBase	Search...
Protein-protein interaction databases
STRING	326298.Suden_1048.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB44326; ABB44326; Suden_1048.
GeneID	3763932.
KEGG	tdn:Suden_1048.
PATRIC	23770698. VBISulDen68967_1089.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0039.
HOGENOM	HOG000213794.
KO	K00024.
OMA	KAFVICI.
ProtClustDB	PRK06223.
Enzyme and pathway databases
BioCyc	SDEN326298:GH9P-1107-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 1 hit. 3.90.110.10. 1 hit.
HAMAP	MF_00487. Malate_dehydrog_3.
InterPro	IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR011275. Malate_DH_type3. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11540. PTHR11540. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
PRINTS	PR00086. LLDHDRGNASE.
SUPFAM	SSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMs	TIGR01763. MalateDH_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MDH_SULDN

Accession

Primary (citable) accession number: Q30RQ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents