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Q30RQ5 (MDH_SULDN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

malate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Malate dehydrogenase HAMAP-Rule MF_00487
PRO_0000241969

Regions

Nucleotide binding11 – 166NAD By similarity
Nucleotide binding121 – 1233NAD By similarity

Sites

Active site1781Proton acceptor By similarity
Binding site361NAD By similarity
Binding site851Substrate By similarity
Binding site911Substrate By similarity
Binding site981NAD By similarity
Binding site1231Substrate By similarity
Binding site1541Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q30RQ5 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 880F5C01E08E221C

FASTA31933,698
        10         20         30         40         50         60 
MNQGKRVGII GAGNVGATVA YSLAMLGSCH EIILRDNKID VAKGKALDMS QAAAAVRSHT 

        70         80         90        100        110        120 
IVSVAEEMAD LTNCDVVVVT AGSPRLPGMS RDDLLMINAN ITKDVIAGVA KYSPDAIIIM 

       130        140        150        160        170        180 
VSNPLDAMTY VALKESGFDR SRVIGMAGIL DSARMASFIQ EKLGYGGGQI RASVMGGHGD 

       190        200        210        220        230        240 
DMVPLARYST VAGVPLTDLM STSEINEIVI RTRNGGAEIV GHLKTGSAYY APAKATALMV 

       250        260        270        280        290        300 
EAILKDTKQI HPCAVFLEGE YGHSDVVSGV PVMLGANGAE KIIEISLDES EKIMFEGSCN 

       310 
SVRTLIDTLN KNKFFDKGE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000153 Genomic DNA. Translation: ABB44326.1.
RefSeqYP_393561.1. NC_007575.1.

3D structure databases

ProteinModelPortalQ30RQ5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326298.Suden_1048.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB44326; ABB44326; Suden_1048.
GeneID3763932.
KEGGtdn:Suden_1048.
PATRIC23770698. VBISulDen68967_1089.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213794.
KOK00024.
OMAYGQNDIC.
OrthoDBEOG6091FG.

Enzyme and pathway databases

BioCycSDEN326298:GH9P-1090-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01763. MalateDH_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_SULDN
AccessionPrimary (citable) accession number: Q30RQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families