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Protein

Malate dehydrogenase

Gene

mdh

Organism
Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADUniRule annotation1
Binding sitei85SubstrateUniRule annotation1
Binding sitei91SubstrateUniRule annotation1
Binding sitei98NADUniRule annotation1
Binding sitei123SubstrateUniRule annotation1
Binding sitei154SubstrateUniRule annotation1
Active sitei178Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADUniRule annotation6
Nucleotide bindingi121 – 123NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciSDEN326298:G1G5D-1106-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:Suden_1048
OrganismiSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Taxonomic identifieri326298 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
Proteomesi
  • UP000002714 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002419691 – 319Malate dehydrogenaseAdd BLAST319

Interactioni

Protein-protein interaction databases

STRINGi326298.Suden_1048

Structurei

3D structure databases

ProteinModelPortaliQ30RQ5
SMRiQ30RQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiMDLMQTA
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q30RQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQGKRVGII GAGNVGATVA YSLAMLGSCH EIILRDNKID VAKGKALDMS
60 70 80 90 100
QAAAAVRSHT IVSVAEEMAD LTNCDVVVVT AGSPRLPGMS RDDLLMINAN
110 120 130 140 150
ITKDVIAGVA KYSPDAIIIM VSNPLDAMTY VALKESGFDR SRVIGMAGIL
160 170 180 190 200
DSARMASFIQ EKLGYGGGQI RASVMGGHGD DMVPLARYST VAGVPLTDLM
210 220 230 240 250
STSEINEIVI RTRNGGAEIV GHLKTGSAYY APAKATALMV EAILKDTKQI
260 270 280 290 300
HPCAVFLEGE YGHSDVVSGV PVMLGANGAE KIIEISLDES EKIMFEGSCN
310
SVRTLIDTLN KNKFFDKGE
Length:319
Mass (Da):33,698
Last modified:December 6, 2005 - v1
Checksum:i880F5C01E08E221C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000153 Genomic DNA Translation: ABB44326.1
RefSeqiWP_011372678.1, NC_007575.1

Genome annotation databases

EnsemblBacteriaiABB44326; ABB44326; Suden_1048
KEGGitdn:Suden_1048

Similar proteinsi

Entry informationi

Entry nameiMDH_SULDN
AccessioniPrimary (citable) accession number: Q30RQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 6, 2005
Last modified: February 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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