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Q30R95 (DDL_SULDN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:Suden_1208
OrganismSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251)) [Complete proteome] [HAMAP]
Taxonomic identifier326298 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341179

Regions

Domain133 – 332200ATP-grasp
Nucleotide binding160 – 21152ATP By similarity

Sites

Metal binding2841Magnesium or manganese 1 By similarity
Metal binding2961Magnesium or manganese 1 By similarity
Metal binding2961Magnesium or manganese 2 By similarity
Metal binding2981Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q30R95 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: A98030DFD74AF478

FASTA34538,726
        10         20         30         40         50         60 
MKLTILFGGA SFEHEISIVS AITLKEKLSN FELNFIFCDQ DHTFYLINAS KMRATTFSRG 

        70         80         90        100        110        120 
EYKKMPKLTL SHGSFVQKSL FGSVDISGTV LNLIHGGDGE DGTIAAILDF FSIKYIGPRV 

       130        140        150        160        170        180 
DASVFSYDKR YTKWLCHARG VKCVESQELS SSEHSNIKIA YPIIVKPSRL GSSIGVSIVK 

       190        200        210        220        230        240 
DESKLDYALD SAFEFDNTVI VEPFLEGVKE YNLAGFSAGK KFYFSIIEEP QKEEFLDFEK 

       250        260        270        280        290        300 
KYMDFSRSGN VDSAEISKEL ESKLRASFEK VYKNLFEGAL IRCDFFVVNG EVFLNEINPI 

       310        320        330        340 
PGSMANYLFD DFGGSLKLLA NSLPHTKRAK VTYEYIHSIS KAKGK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000153 Genomic DNA. Translation: ABB44486.1.
RefSeqYP_393721.1. NC_007575.1.

3D structure databases

ProteinModelPortalQ30R95.
SMRQ30R95. Positions 1-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326298.Suden_1208.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB44486; ABB44486; Suden_1208.
GeneID3763570.
KEGGtdn:Suden_1208.
PATRIC23771040. VBISulDen68967_1255.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000102494.
KOK01921.
OMAHNGLLKN.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycSDEN326298:GH9P-1256-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_SULDN
AccessionPrimary (citable) accession number: Q30R95
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways