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Q30QK3

- Q30QK3_SULDN

UniProt

Q30QK3 - Q30QK3_SULDN

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Protein

Acetyl-coenzyme A synthetase

Gene

acsA

Organism
Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Note: Magnesium.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei307 – 3071Coenzyme AUniRule annotation
Binding sitei500 – 5001ATPUniRule annotation
Binding sitei515 – 5151ATPUniRule annotation
Binding sitei523 – 5231Coenzyme A; via carbonyl oxygenUniRule annotation
Binding sitei526 – 5261ATPUniRule annotation
Metal bindingi539 – 5391Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi542 – 5421Magnesium; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi383 – 3853ATPUniRule annotation

GO - Molecular functioni

  1. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  2. AMP binding Source: InterPro
  3. ATP binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSDEN326298:GH9P-1500-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligaseUniRule annotation
Acyl-activating enzymeUniRule annotation
Gene namesi
Name:acsAUniRule annotation
Ordered Locus Names:Suden_1451Imported
OrganismiSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))Imported
Taxonomic identifieri326298 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
ProteomesiUP000002714: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei611 – 6111N6-acetyllysineUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi326298.Suden_1451.

Structurei

3D structure databases

ProteinModelPortaliQ30QK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni189 – 1924Coenzyme A bindingUniRule annotation

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiGGCEAVT.
OrthoDBiEOG68WR2H.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q30QK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNREVFKPNK EFSKSARIKN MCEYQDLQEY ALEDYEGFWG SYAKEKLEWM
60 70 80 90 100
QPFTNVMNES NFPFVKWFEG GKLNVSVQCI DRHLKSRKNK AAIIFEGDRG
110 120 130 140 150
DKQIITYLEL YYNVNKFANL LKNEFDVKKG DRVIIYMPMI PEAAYAMLAC
160 170 180 190 200
ARIGAIHSIV FGGFSAEALK DRVIDAGAKV VITADGAYRK DKPYMLKPVV
210 220 230 240 250
DEALRGETPV KKVLVVERNG EDVTWVAGRD YSYNELIKHQ SGKCEPEVMD
260 270 280 290 300
SEDPLFLLYT SGSTGKPKGV QHNSAGYILW AQMTMEWVFD VKENDTYWCT
310 320 330 340 350
ADVGWITGHT YIVYGPLAMG ATTIMFEGVP TYPDAGRPWK MVEEYKVNQF
360 370 380 390 400
YTAPTAIRVL HKTGENEPAK YDLSSLKVLG TVGEPIDPPA WKWYYEAIGG
410 420 430 440 450
SKCAIVDTYW QTETGGHIVS PLPGATPIKP ACATFPLPGI MAEILDENGN
460 470 480 490 500
RAEVGEKGLM CVTRPWPAMI RGVWGDEERF VKSYFGDVKK DGKPVYFTGD
510 520 530 540 550
GAIYDEDGYI TITGRTDDVI NVSGHRMGTA EVEAAIKKHP NVAEVAVVGK
560 570 580 590 600
PHEIKGEGIF AYIVLKSDSG IADEVEEVKA INKVIQKEIG NIALCDDVVF
610 620 630 640 650
VVGLPKTRSG KIMRRILRSI AKGEEITQDI STLEDPSIVA TIASAVQSCR

L
Length:651
Mass (Da):72,616
Last modified:December 6, 2005 - v1
Checksum:i7A53E3EDCBB4CCC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000153 Genomic DNA. Translation: ABB44728.1.
RefSeqiWP_011373080.1. NC_007575.1.
YP_393963.1. NC_007575.1.

Genome annotation databases

EnsemblBacteriaiABB44728; ABB44728; Suden_1451.
GeneIDi3763349.
KEGGitdn:Suden_1451.
PATRICi23771544. VBISulDen68967_1506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000153 Genomic DNA. Translation: ABB44728.1 .
RefSeqi WP_011373080.1. NC_007575.1.
YP_393963.1. NC_007575.1.

3D structure databases

ProteinModelPortali Q30QK3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326298.Suden_1451.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB44728 ; ABB44728 ; Suden_1451 .
GeneIDi 3763349.
KEGGi tdn:Suden_1451.
PATRICi 23771544. VBISulDen68967_1506.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi GGCEAVT.
OrthoDBi EOG68WR2H.

Enzyme and pathway databases

BioCyci SDEN326298:GH9P-1500-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33889 / DSM 1251Imported.

Entry informationi

Entry nameiQ30QK3_SULDN
AccessioniPrimary (citable) accession number: Q30QK3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 26, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3