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Q30Q82

- SYL_SULDN

UniProt

Q30Q82 - SYL_SULDN

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei593 – 5931ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSDEN326298:GH9P-1621-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Suden_1572
OrganismiSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Taxonomic identifieri326298 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
ProteomesiUP000002714: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 822822Leucine--tRNA ligasePRO_1000091373Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326298.Suden_1572.

Structurei

3D structure databases

ProteinModelPortaliQ30Q82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionAdd
BLAST
Motifi590 – 5945"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q30Q82-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIYNSKELEK KWQEYWAKNR SFEPSEDFTK ETGCPRGKKY ILSMFPFPSG
60 70 80 90 100
RLHMGHVRNY TISDAFARYY RQEGFNVLHP IGFDSFGMPA ENAAIKNGSH
110 120 130 140 150
PKKWTYDNID YMKGEFKSLG FSFSKDRELA TSDELYTKFE QGFIIDMYEK
160 170 180 190 200
GLLYRKKGFL NWCPSCHTVL ANEQVIDGSC WRCDSSVVKK DMNQYYFKIT
210 220 230 240 250
QYGDELLADL SKLESGWPKQ VLTMQENWIG KSNGLEFKLS FDEKSLEKLD
260 270 280 290 300
NKFDTFSVFT TRPDTIYGVS YAALAPEHEI VSYMIENALV GSDTIEKIKE
310 320 330 340 350
MKNASSIERQ KEKSGIALNL HVVHPLTKKL IPIWVANFVL MDYGSGAVMA
360 370 380 390 400
VPAHDERDFD FAKKYNLPIK AVIKPFDGES SIESAFTEVG ELFDSEMFNG
410 420 430 440 450
LNSKDAQLKI IEHFEEKKIG KKTTNYKLKD WGVSRQRYWG APIPFVHCDS
460 470 480 490 500
CGIVMEKKEN LPIALPEDIE ITGEGNPLEK HPTWKYCKCP KCDKDAIRET
510 520 530 540 550
DTMDTFVESS WYFLRFCASP KNWLNEAFSK EQIKYWMGVD HYIGGIEHAI
560 570 580 590 600
LHLLYARFFT KVFRDLGYLE FDEPFNKLLT QGMVLKDGAK MSKSKGNTVD
610 620 630 640 650
PDAIIEKYGA DTARLFILFA APPTQELEWN DNAVEGAFKF IKRFYERSVN
660 670 680 690 700
AIKTNTIPKI NHASLSKEEK FARKKVYEAL VRSREVYGEK YTFNTMIAGV
710 720 730 740 750
MEAMNALNLQ TNSDVWSEAY WILTSIMEPV IPHVCSEISS VKFSLKNLSS
760 770 780 790 800
QIVVQEVFVE DSLMLGVTVN GKRRCEIEVP TEATQDEILQ IARESASKWL
810 820
EGKTIIKEIV VPKKLVNLVI KD
Length:822
Mass (Da):94,408
Last modified:December 6, 2005 - v1
Checksum:i202B10DAC105403F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000153 Genomic DNA. Translation: ABB44849.1.
RefSeqiWP_011373201.1. NC_007575.1.
YP_394084.1. NC_007575.1.

Genome annotation databases

EnsemblBacteriaiABB44849; ABB44849; Suden_1572.
GeneIDi3763166.
KEGGitdn:Suden_1572.
PATRICi23771794. VBISulDen68967_1631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000153 Genomic DNA. Translation: ABB44849.1 .
RefSeqi WP_011373201.1. NC_007575.1.
YP_394084.1. NC_007575.1.

3D structure databases

ProteinModelPortali Q30Q82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326298.Suden_1572.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB44849 ; ABB44849 ; Suden_1572 .
GeneIDi 3763166.
KEGGi tdn:Suden_1572.
PATRICi 23771794. VBISulDen68967_1631.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SDEN326298:GH9P-1621-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33889 / DSM 1251.

Entry informationi

Entry nameiSYL_SULDN
AccessioniPrimary (citable) accession number: Q30Q82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3