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Q30Q82

- SYL_SULDN

UniProt

Q30Q82 - SYL_SULDN

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Protein
Leucine--tRNA ligase
Gene
leuS, Suden_1572
Organism
Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei593 – 5931ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSDEN326298:GH9P-1621-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:Suden_1572
OrganismiSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Taxonomic identifieri326298 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
ProteomesiUP000002714: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 822822Leucine--tRNA ligaseUniRule annotation
PRO_1000091373Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi326298.Suden_1572.

Structurei

3D structure databases

ProteinModelPortaliQ30Q82.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi46 – 5611"HIGH" regionUniRule annotation
Add
BLAST
Motifi590 – 5945"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q30Q82-1 [UniParc]FASTAAdd to Basket

« Hide

MIYNSKELEK KWQEYWAKNR SFEPSEDFTK ETGCPRGKKY ILSMFPFPSG    50
RLHMGHVRNY TISDAFARYY RQEGFNVLHP IGFDSFGMPA ENAAIKNGSH 100
PKKWTYDNID YMKGEFKSLG FSFSKDRELA TSDELYTKFE QGFIIDMYEK 150
GLLYRKKGFL NWCPSCHTVL ANEQVIDGSC WRCDSSVVKK DMNQYYFKIT 200
QYGDELLADL SKLESGWPKQ VLTMQENWIG KSNGLEFKLS FDEKSLEKLD 250
NKFDTFSVFT TRPDTIYGVS YAALAPEHEI VSYMIENALV GSDTIEKIKE 300
MKNASSIERQ KEKSGIALNL HVVHPLTKKL IPIWVANFVL MDYGSGAVMA 350
VPAHDERDFD FAKKYNLPIK AVIKPFDGES SIESAFTEVG ELFDSEMFNG 400
LNSKDAQLKI IEHFEEKKIG KKTTNYKLKD WGVSRQRYWG APIPFVHCDS 450
CGIVMEKKEN LPIALPEDIE ITGEGNPLEK HPTWKYCKCP KCDKDAIRET 500
DTMDTFVESS WYFLRFCASP KNWLNEAFSK EQIKYWMGVD HYIGGIEHAI 550
LHLLYARFFT KVFRDLGYLE FDEPFNKLLT QGMVLKDGAK MSKSKGNTVD 600
PDAIIEKYGA DTARLFILFA APPTQELEWN DNAVEGAFKF IKRFYERSVN 650
AIKTNTIPKI NHASLSKEEK FARKKVYEAL VRSREVYGEK YTFNTMIAGV 700
MEAMNALNLQ TNSDVWSEAY WILTSIMEPV IPHVCSEISS VKFSLKNLSS 750
QIVVQEVFVE DSLMLGVTVN GKRRCEIEVP TEATQDEILQ IARESASKWL 800
EGKTIIKEIV VPKKLVNLVI KD 822
Length:822
Mass (Da):94,408
Last modified:December 6, 2005 - v1
Checksum:i202B10DAC105403F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000153 Genomic DNA. Translation: ABB44849.1.
RefSeqiWP_011373201.1. NC_007575.1.
YP_394084.1. NC_007575.1.

Genome annotation databases

EnsemblBacteriaiABB44849; ABB44849; Suden_1572.
GeneIDi3763166.
KEGGitdn:Suden_1572.
PATRICi23771794. VBISulDen68967_1631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000153 Genomic DNA. Translation: ABB44849.1 .
RefSeqi WP_011373201.1. NC_007575.1.
YP_394084.1. NC_007575.1.

3D structure databases

ProteinModelPortali Q30Q82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 326298.Suden_1572.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB44849 ; ABB44849 ; Suden_1572 .
GeneIDi 3763166.
KEGGi tdn:Suden_1572.
PATRICi 23771794. VBISulDen68967_1631.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SDEN326298:GH9P-1621-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33889 / DSM 1251.

Entry informationi

Entry nameiSYL_SULDN
AccessioniPrimary (citable) accession number: Q30Q82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi