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Q30Q82

- SYL_SULDN

UniProt

Q30Q82 - SYL_SULDN

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei593 – 5931ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSDEN326298:GH9P-1621-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:Suden_1572
    OrganismiSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251))
    Taxonomic identifieri326298 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas
    ProteomesiUP000002714: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 822822Leucine--tRNA ligasePRO_1000091373Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi326298.Suden_1572.

    Structurei

    3D structure databases

    ProteinModelPortaliQ30Q82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 5611"HIGH" regionAdd
    BLAST
    Motifi590 – 5945"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q30Q82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIYNSKELEK KWQEYWAKNR SFEPSEDFTK ETGCPRGKKY ILSMFPFPSG    50
    RLHMGHVRNY TISDAFARYY RQEGFNVLHP IGFDSFGMPA ENAAIKNGSH 100
    PKKWTYDNID YMKGEFKSLG FSFSKDRELA TSDELYTKFE QGFIIDMYEK 150
    GLLYRKKGFL NWCPSCHTVL ANEQVIDGSC WRCDSSVVKK DMNQYYFKIT 200
    QYGDELLADL SKLESGWPKQ VLTMQENWIG KSNGLEFKLS FDEKSLEKLD 250
    NKFDTFSVFT TRPDTIYGVS YAALAPEHEI VSYMIENALV GSDTIEKIKE 300
    MKNASSIERQ KEKSGIALNL HVVHPLTKKL IPIWVANFVL MDYGSGAVMA 350
    VPAHDERDFD FAKKYNLPIK AVIKPFDGES SIESAFTEVG ELFDSEMFNG 400
    LNSKDAQLKI IEHFEEKKIG KKTTNYKLKD WGVSRQRYWG APIPFVHCDS 450
    CGIVMEKKEN LPIALPEDIE ITGEGNPLEK HPTWKYCKCP KCDKDAIRET 500
    DTMDTFVESS WYFLRFCASP KNWLNEAFSK EQIKYWMGVD HYIGGIEHAI 550
    LHLLYARFFT KVFRDLGYLE FDEPFNKLLT QGMVLKDGAK MSKSKGNTVD 600
    PDAIIEKYGA DTARLFILFA APPTQELEWN DNAVEGAFKF IKRFYERSVN 650
    AIKTNTIPKI NHASLSKEEK FARKKVYEAL VRSREVYGEK YTFNTMIAGV 700
    MEAMNALNLQ TNSDVWSEAY WILTSIMEPV IPHVCSEISS VKFSLKNLSS 750
    QIVVQEVFVE DSLMLGVTVN GKRRCEIEVP TEATQDEILQ IARESASKWL 800
    EGKTIIKEIV VPKKLVNLVI KD 822
    Length:822
    Mass (Da):94,408
    Last modified:December 6, 2005 - v1
    Checksum:i202B10DAC105403F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000153 Genomic DNA. Translation: ABB44849.1.
    RefSeqiWP_011373201.1. NC_007575.1.
    YP_394084.1. NC_007575.1.

    Genome annotation databases

    EnsemblBacteriaiABB44849; ABB44849; Suden_1572.
    GeneIDi3763166.
    KEGGitdn:Suden_1572.
    PATRICi23771794. VBISulDen68967_1631.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000153 Genomic DNA. Translation: ABB44849.1 .
    RefSeqi WP_011373201.1. NC_007575.1.
    YP_394084.1. NC_007575.1.

    3D structure databases

    ProteinModelPortali Q30Q82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 326298.Suden_1572.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB44849 ; ABB44849 ; Suden_1572 .
    GeneIDi 3763166.
    KEGGi tdn:Suden_1572.
    PATRICi 23771794. VBISulDen68967_1631.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci SDEN326298:GH9P-1621-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33889 / DSM 1251.

    Entry informationi

    Entry nameiSYL_SULDN
    AccessioniPrimary (citable) accession number: Q30Q82
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3