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Q30Q82 (SYL_SULDN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:Suden_1572
OrganismSulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251)) [Complete proteome] [HAMAP]
Taxonomic identifier326298 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeSulfurimonas

Protein attributes

Sequence length822 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 822822Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000091373

Regions

Motif46 – 5611"HIGH" region HAMAP-Rule MF_00049
Motif590 – 5945"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5931ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q30Q82 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 202B10DAC105403F

FASTA82294,408
        10         20         30         40         50         60 
MIYNSKELEK KWQEYWAKNR SFEPSEDFTK ETGCPRGKKY ILSMFPFPSG RLHMGHVRNY 

        70         80         90        100        110        120 
TISDAFARYY RQEGFNVLHP IGFDSFGMPA ENAAIKNGSH PKKWTYDNID YMKGEFKSLG 

       130        140        150        160        170        180 
FSFSKDRELA TSDELYTKFE QGFIIDMYEK GLLYRKKGFL NWCPSCHTVL ANEQVIDGSC 

       190        200        210        220        230        240 
WRCDSSVVKK DMNQYYFKIT QYGDELLADL SKLESGWPKQ VLTMQENWIG KSNGLEFKLS 

       250        260        270        280        290        300 
FDEKSLEKLD NKFDTFSVFT TRPDTIYGVS YAALAPEHEI VSYMIENALV GSDTIEKIKE 

       310        320        330        340        350        360 
MKNASSIERQ KEKSGIALNL HVVHPLTKKL IPIWVANFVL MDYGSGAVMA VPAHDERDFD 

       370        380        390        400        410        420 
FAKKYNLPIK AVIKPFDGES SIESAFTEVG ELFDSEMFNG LNSKDAQLKI IEHFEEKKIG 

       430        440        450        460        470        480 
KKTTNYKLKD WGVSRQRYWG APIPFVHCDS CGIVMEKKEN LPIALPEDIE ITGEGNPLEK 

       490        500        510        520        530        540 
HPTWKYCKCP KCDKDAIRET DTMDTFVESS WYFLRFCASP KNWLNEAFSK EQIKYWMGVD 

       550        560        570        580        590        600 
HYIGGIEHAI LHLLYARFFT KVFRDLGYLE FDEPFNKLLT QGMVLKDGAK MSKSKGNTVD 

       610        620        630        640        650        660 
PDAIIEKYGA DTARLFILFA APPTQELEWN DNAVEGAFKF IKRFYERSVN AIKTNTIPKI 

       670        680        690        700        710        720 
NHASLSKEEK FARKKVYEAL VRSREVYGEK YTFNTMIAGV MEAMNALNLQ TNSDVWSEAY 

       730        740        750        760        770        780 
WILTSIMEPV IPHVCSEISS VKFSLKNLSS QIVVQEVFVE DSLMLGVTVN GKRRCEIEVP 

       790        800        810        820 
TEATQDEILQ IARESASKWL EGKTIIKEIV VPKKLVNLVI KD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000153 Genomic DNA. Translation: ABB44849.1.
RefSeqYP_394084.1. NC_007575.1.

3D structure databases

ProteinModelPortalQ30Q82.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING326298.Suden_1572.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB44849; ABB44849; Suden_1572.
GeneID3763166.
KEGGtdn:Suden_1572.
PATRIC23771794. VBISulDen68967_1631.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAHISHELW.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycSDEN326298:GH9P-1621-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_SULDN
AccessionPrimary (citable) accession number: Q30Q82
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries