Reviewed, UniProtKB/Swiss-Prot Q30P60 (GLYA2_SULDN)

Names and origin

Protein names

Recommended name:
    Serine hydroxymethyltransferase 2
      Short name=Serine methylase 2
      Short name=SHMT 2
    EC=2.1.2.1

Gene names

Name:	glyA2
Ordered Locus Names:	Suden_1947

Organism

Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251)) [Complete proteome] [HAMAP]

Taxonomic identifier

326298 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Sulfurimonas

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Interconversion of serine and glycine. HAMAP MF_00051
Catalytic activity	5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine. HAMAP MF_00051
Cofactor	Pyridoxal phosphate By similarity.
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_00051
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the SHMT family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-serine metabolic process Inferred from electronic annotation. Source: InterPro glycine metabolic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycine hydroxymethyltransferase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	Serine hydroxymethyltransferase 2 HAMAP MF_00051		PRO_0000235046
Amino acid modifications
	Modified residue	230	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q30P60-1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 91DAC8E1BE86D543	FASTA	420	45,706
	10 20 30 40 50 60 MSFISSKSLE HADREVFSII EGELKRQTAH LEMIASENFT SPAVMEAMGS VFTNKYAEGY 70 80 90 100 110 120 PYKRYYGGCE YADAVEQLAI DRACEIFGCK FANVQPHSGS QANAAVYAAL LKAGDKLLGM 130 140 150 160 170 180 DLSHGGHLTH GSKPSFSGQN YSSFTYGVEA DGRMDYDKIL EIAKAVQPKI IVCGASAYAR 190 200 210 220 230 240 EIDFKKFREI ADAVGAFLFA DIAHVAGLVA ADEHMSPFPH AHVVTTTTHK TLRGPRGGMI 250 260 270 280 290 300 MTDDEEIAKK INSAIFPGIQ GGPLVHVIAA KAVAFKEILD PSWREYAKQV KANAKVLEVV 310 320 330 340 350 360 LTKRGYDLVS GGTDNHLVLV SFLNRDFSGK DADAALERAG ITVNKNGVPN DTRSPFITSG 370 380 390 400 410 420 IRIGSPALTA RGMKEAEFEL IANKICDVLD NINDTELHVK INKELEELAK GFVIYNKSTF

References

[1]

"Genome of the epsilonproteobacterial chemolithoautotroph Sulfurimonas denitrificans." Sievert S.M., Scott K.M., Klotz M.G., Chain P.S.G., Hauser L.J., Hemp J., Huegler M., Land M., Lapidus A., Larimer F.W., Lucas S., Malfatti S.A., Meyer F., Paulsen I.T., Ren Q., Simon J., Bailey K., Diaz E. , Fitzpatrick K.A., Glover B., Gwatney N., Korajkic A., Long A., Mobberley J.M., Pantry S.N., Pazder G., Peterson S., Quintanilla J.D., Sprinkle R., Stephens J., Thomas P., Vaughn R., Weber M.J., Wooten L.L. Appl. Environ. Microbiol. 74:1145-1156(2008) [PubMed: 18065616] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000153 Genomic DNA. Translation: ABB45221.1.
RefSeq	YP_394456.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q30P60.
Genome annotation databases
GeneID	3762951.
GenomeReviews	Gene locus Suden_1947 in contig CP000153_GR.
KEGG	tdn:Suden_1947.
NMPDR	fig|326298.3.peg.408.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q30P60.
OMA	DNINDTE.
Enzyme and pathway databases
BioCyc	TDEN326298:TMDEN_1947-MON.
Family and domain databases
HAMAP	MF_00051. [Tree]
InterPro	IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR001085. Ser_HO-MeTrfase. IPR019798. Ser_HO-MeTrfase_PLP_BS. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11680. Gly_HO-Metrfase. 1 hit.
Pfam	PF00464. SHMT. 1 hit. [Graphical view]
PIRSF	PIRSF000412. SHMT. 1 hit.
PROSITE	PS00096. SHMT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLYA2_SULDN

Accession

Primary (citable) accession number: Q30P60

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	December 6, 2005
Last modified:	November 3, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)