Q30NS1 (Q30NS1_SULDN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1 HAMAP MF_00223
EC=3.5.4.16 HAMAP MF_00223

Alternative name(s):
GTP cyclohydrolase I HAMAP MF_00223

Gene names

Name:	folE HAMAP MF_00223
Ordered Locus Names:	Suden_2086

Organism

Sulfurimonas denitrificans (strain ATCC 33889 / DSM 1251) (Thiomicrospira denitrificans (strain ATCC 33889 / DSM 1251)) [Complete proteome] [HAMAP]

Taxonomic identifier

326298 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Helicobacteraceae › Sulfurimonas

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223 SAAS SAAS001474
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223 SAAS SAAS001474
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family. HAMAP MF_00223

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_00223
Ligand	GTP-binding HAMAP MF_00223 Metal-binding HAMAP MF_00223 SAAS SAAS001474 Nucleotide-binding Zinc HAMAP MF_00223 SAAS SAAS001474
Molecular function	Hydrolase HAMAP MF_00223 SAAS SAAS001474 EMBL ABB45360.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	64	1	Zinc By similarity HAMAP MF_00223
	Metal binding	67	1	Zinc By similarity HAMAP MF_00223
	Metal binding	135	1	Zinc By similarity HAMAP MF_00223

Sequences

	Sequence		Length	Mass (Da)
	Q30NS1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 1DB460226EF997DE	FASTA	179	20,302
	10 20 30 40 50 60 MMLHVGENPD REGLLKTPQR VKKAYEFIFG GYKEDPEEIL NSALFTSSND EMVLLKDIEF 70 80 90 100 110 120 YSTCEHHLLP IIGRVHVAYI PNGKVVGLSK IPRVVNVFAR RMQIQEQLTE QIADAIMNTI 130 140 150 160 170 KPKGVAVVVQ ARHMCMEMRG VEKINSTTTS SALRGLFKKD EKTRSEFFSL INSPNGSRY

References

[1]

"Genome of the epsilonproteobacterial chemolithoautotroph Sulfurimonas denitrificans." Sievert S.M., Scott K.M., Klotz M.G., Chain P.S.G., Hauser L.J., Hemp J., Huegler M., Land M., Lapidus A., Larimer F.W., Lucas S., Malfatti S.A., Meyer F., Paulsen I.T., Ren Q., Simon J., Bailey K., Diaz E. , Fitzpatrick K.A., Glover B., Gwatney N., Korajkic A., Long A., Mobberley J.M., Pantry S.N., Pazder G., Peterson S., Quintanilla J.D., Sprinkle R., Stephens J., Thomas P., Vaughn R., Weber M.J., Wooten L.L. Appl. Environ. Microbiol. 74:1145-1156(2008) [PubMed: 18065616] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000153 Genomic DNA. Translation: ABB45360.1.
RefSeq	YP_394595.1. NC_007575.1.
3D structure databases
ProteinModelPortal	Q30NS1.
SMR	Q30NS1. Positions 2-172.
ModBase	Search...
Protein-protein interaction databases
STRING	Q30NS1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3763097.
GenomeReviews	Gene locus Suden_2086 in contig CP000153_GR.
KEGG	tdn:Suden_2086.
NMPDR	fig|326298.3.peg.808.
PATRIC	23772882. VBISulDen68967_2167.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HBG370191.
OMA	CIESTTG.
ProtClustDB	PRK09347.
Enzyme and pathway databases
BioCyc	TDEN326298:TMDEN_2086-MONOMER.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q30NS1_SULDN

Accession

Primary (citable) accession number: Q30NS1

Entry history

Integrated into UniProtKB/TrEMBL:	December 6, 2005
Last sequence update:	December 6, 2005
Last modified:	December 14, 2011
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)