ID   DB109_HUMAN             Reviewed;          87 AA.
AC   Q30KR1;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   08-NOV-2023, entry version 91.
DE   RecName: Full=Putative beta-defensin 109B;
DE   AltName: Full=Defensin, beta 109, pseudogene 1B;
DE   AltName: Full=Defensin, beta 109B {ECO:0000312|HGNC:HGNC:33469};
DE   Flags: Precursor;
GN   Name=DEFB109B {ECO:0000312|HGNC:HGNC:33469}; Synonyms=DEFB109P1B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; DQ012013; AAY59749.1; -; mRNA.
DR   AlphaFoldDB; Q30KR1; -.
DR   BioMuta; HGNC:33469; -.
DR   DMDM; 84028868; -.
DR   PeptideAtlas; Q30KR1; -.
DR   Ensembl; ENST00000382656.2; ENSP00000516541.1; ENSG00000206034.2.
DR   MANE-Select; ENST00000382656.2; ENSP00000516541.1; NM_001037380.2; NP_001032457.1.
DR   AGR; HGNC:33469; -.
DR   GeneCards; DEFB109B; -.
DR   HGNC; HGNC:33469; DEFB109B.
DR   HPA; ENSG00000206034; Tissue enriched (epididymis).
DR   neXtProt; NX_Q30KR1; -.
DR   GeneTree; ENSGT00940000160995; -.
DR   InParanoid; Q30KR1; -.
DR   OrthoDB; 5265360at2759; -.
DR   PhylomeDB; Q30KR1; -.
DR   PathwayCommons; Q30KR1; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   SignaLink; Q30KR1; -.
DR   Pharos; Q30KR1; Tdark.
DR   PRO; PR:Q30KR1; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q30KR1; Protein.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   PANTHER; PTHR20515; BETA-DEFENSIN; 1.
DR   PANTHER; PTHR20515:SF3; BETA-DEFENSIN 109B-RELATED; 1.
DR   SUPFAM; SSF57392; Defensin-like; 1.
PE   5: Uncertain;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..87
FT                   /note="Putative beta-defensin 109B"
FT                   /id="PRO_0000045333"
FT   DISULFID        31..59
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..53
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..60
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   87 AA;  9886 MW;  F9C501C495B608ED CRC64;
     MRLHLLLLIL LLFSILLSPV RGGLGPAEGH CLNLFGVCRT DVCNIVEDQI GACRRRMKCC
     RAWWILMPIP TPLIMSDYQE PLKPNLK
//